Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
← Back to all clusters
Cluster 165
9
Diseases
16
Unique genes
0.204
Avg. similarity score
Cleft lip with or without cleft palate
Most-connected disease (7 links)
Disease
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) ·
drag a node to pin it in place · scroll/pinch to zoom.
Cleft lip with or without cleft palate
Blepharocheilodontic syndrome
CDH1-related diffuse gastric and lobular breast cancer syndrome
Hereditary diffuse gastric and lobular breast cancer syndrome
Lobular carcinoma
Trigeminal nerve disease
blepharocheilodontic syndrome 2
ARHGAP29-related non-syndromic orofacial cleft
Bilateral cleft lip
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Cleft lip with or without cleft palate | 7 | 7 | 6 |
| Blepharocheilodontic syndrome | 6 | 6 | 2 |
| CDH1-related diffuse gastric and lobular breast cancer syndrome | 4 | 4 | 1 |
| Hereditary diffuse gastric and lobular breast cancer syndrome | 4 | 4 | 1 |
| Lobular carcinoma | 3 | 3 | 6 |
| Trigeminal nerve disease | 3 | 3 | 6 |
| blepharocheilodontic syndrome 2 | 3 | 3 | 1 |
| ARHGAP29-related non-syndromic orofacial cleft | 1 | 1 | 1 |
| Bilateral cleft lip | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| CDH1 | 5 / 9 | Blepharocheilodontic syndrome, CDH1-related diffuse gastric and lobular breast cancer syndrome, Cleft lip with or without cleft palate, Hereditary diffuse gastric and lobular breast cancer syndrome and 1 more |
| CTNND1 | 4 / 9 | Blepharocheilodontic syndrome, blepharocheilodontic syndrome 2, Cleft lip with or without cleft palate, Trigeminal nerve disease |
| ARHGAP29 | 2 / 9 | ARHGAP29-related non-syndromic orofacial cleft, Cleft lip with or without cleft palate |
| PLEKHA5 | 2 / 9 | Bilateral cleft lip, Cleft lip with or without cleft palate |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| InlA-mediated entry of Listeria monocytogenes into host cells | Reactome | 2 / 9 | 167× | 5.96e-5 | 1.47e-3 ✓ sig. |
| Adherens junction | KEGG | 3 / 93 | 24.2× | 2.34e-4 | 4.43e-3 ✓ sig. |
| RHO GTPases activate PAKs | Reactome | 2 / 23 | 65.3× | 4.14e-4 | 6.89e-3 ✓ sig. |
| Adherens junctions interactions | Reactome | 2 / 32 | 46.9× | 8.06e-4 | 1.16e-2 ✓ sig. |
| Signaling by Leptin | Reactome | 1 / 2 | 375× | 2.66e-3 | 2.83e-2 ✓ sig. |
| CD163 mediating an anti-inflammatory response | Reactome | 1 / 9 | 83.4× | 1.19e-2 | 7.61e-2 |
| Activation of PUMA and translocation to mitochondria | Reactome | 1 / 9 | 83.4× | 1.19e-2 | 7.61e-2 |
| Interleukin-9 signaling | Reactome | 1 / 9 | 83.4× | 1.19e-2 | 7.61e-2 |
| Interleukin-21 signaling | Reactome | 1 / 10 | 75.1× | 1.32e-2 | 8.07e-2 |
| Vascular smooth muscle contraction | KEGG | 2 / 134 | 11.2× | 1.34e-2 | 8.14e-2 |
| Apoptotic cleavage of cell adhesion proteins | Reactome | 1 / 11 | 68.2× | 1.46e-2 | 8.55e-2 |
| TP53 Regulates Transcription of Death Receptors and Ligands | Reactome | 1 / 12 | 62.6× | 1.59e-2 | 9.02e-2 |
| Interleukin-2 signaling | Reactome | 1 / 12 | 62.6× | 1.59e-2 | 9.02e-2 |
| Interleukin-15 signaling | Reactome | 1 / 13 | 57.7× | 1.72e-2 | 9.47e-2 |
| Hippo signaling pathway | KEGG | 2 / 157 | 9.6× | 1.81e-2 | 9.75e-2 |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| cell-cell adhesion mediated by cadherin | GO:0044331 | 4 / 42 | 111× | 3.93e-8 | 5.54e-6 ✓ sig. |
| cell-cell adhesion | GO:0098609 | 5 / 218 | 26.8× | 8.12e-7 | 7.00e-5 ✓ sig. |
| negative regulation of blood vessel branching | GO:1905554 | 1 / 1 | 1,168× | 8.56e-4 | 1.36e-2 ✓ sig. |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | GO:0001991 | 1 / 1 | 1,168× | 8.56e-4 | 1.36e-2 ✓ sig. |
| G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | GO:0007199 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| regulation of metanephros size | GO:0035566 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| negative regulation of miRNA catabolic process | GO:2000626 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| brain renin-angiotensin system | GO:0002035 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| ureteric bud invasion | GO:0072092 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| uropod organization | GO:0032796 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| positive regulation of protein processing in phagocytic vesicle | GO:1903923 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| cortical granule exocytosis | GO:0060471 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| positive regulation of mast cell differentiation | GO:0060376 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| negative regulation of actin filament severing | GO:1903919 | 1 / 2 | 584× | 1.71e-3 | 2.07e-2 ✓ sig. |
| cell adhesion | GO:0007155 | 4 / 665 | 7.0× | 2.05e-3 | 2.30e-2 ✓ sig. |