RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-)
Protein function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:34607910). Forms heterodimeric Rag comp
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
CausalDiseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name
Clinical Significance
dbSNP ID
RCV Accession
Evidence Score
HYPOMAGNESEMIA 7, RENAL, WITH DILATED CARDIOMYOPATHY
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["mTOR signaling pathway","TP53 Regulates Metabolic Genes","Macroautophagy","Regulation of PTEN gene transcription","Amino acids regulate mTORC1","mTOR signalling","mTORC1-mediated signalling","Energy dependent regulation of mTOR by LKB1-AMPK"]
0
[]
Diseases Linked via Similar GenesDiseases curated for genes most similar to RRAGD (see Related Genes above), that are NOT already directly curated for RRAGD itself -- a lead worth checking, not a confirmed association.