PPY (pancreatic polypeptide)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 5539
• Gene name: Pancreatic polypeptide
• Gene symbol: PPY
• Synonyms (NCBI Gene): PH, PNP, PP
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the act

miRNA Show/Hide all (57)

miRTarBase ID	miRNA	Experiments	Reference
MIRT607033	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607032	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT663228	hsa-miR-924	HITS-CLIP	23824327
MIRT663227	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT663226	hsa-miR-431-5p	HITS-CLIP	23824327
MIRT607031	hsa-miR-4504	HITS-CLIP	23824327
MIRT607030	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT607029	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT663225	hsa-miR-5691	HITS-CLIP	23824327
MIRT663224	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT607028	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT663223	hsa-miR-147a	HITS-CLIP	23824327
MIRT663222	hsa-miR-2113	HITS-CLIP	23824327
MIRT663221	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT663220	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT607027	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT607033	hsa-miR-4797-5p	HITS-CLIP	24906430
MIRT607032	hsa-miR-5007-5p	HITS-CLIP	24906430
MIRT607031	hsa-miR-4504	HITS-CLIP	24906430
MIRT607030	hsa-miR-542-3p	HITS-CLIP	24906430
MIRT607029	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT607028	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT607027	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT496360	hsa-miR-6813-3p	PAR-CLIP	22291592
MIRT496359	hsa-miR-29a-3p	PAR-CLIP	22291592
MIRT496358	hsa-miR-29b-3p	PAR-CLIP	22291592
MIRT496357	hsa-miR-29c-3p	PAR-CLIP	22291592
MIRT496356	hsa-miR-6871-3p	PAR-CLIP	22291592
MIRT496355	hsa-miR-3929	PAR-CLIP	22291592
MIRT496354	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496353	hsa-miR-4478	PAR-CLIP	22291592
MIRT496352	hsa-miR-5682	PAR-CLIP	22291592
MIRT607033	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT607032	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT663228	hsa-miR-924	HITS-CLIP	23824327
MIRT663227	hsa-miR-3194-3p	HITS-CLIP	23824327
MIRT663226	hsa-miR-431-5p	HITS-CLIP	23824327
MIRT607031	hsa-miR-4504	HITS-CLIP	23824327
MIRT607030	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT607029	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT663225	hsa-miR-5691	HITS-CLIP	23824327
MIRT663224	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT607028	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT663223	hsa-miR-147a	HITS-CLIP	23824327
MIRT663222	hsa-miR-2113	HITS-CLIP	23824327
MIRT663221	hsa-miR-5010-3p	HITS-CLIP	23824327
MIRT663220	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT607027	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT496360	hsa-miR-6813-3p	PAR-CLIP	22291592
MIRT496359	hsa-miR-29a-3p	PAR-CLIP	22291592
MIRT496358	hsa-miR-29b-3p	PAR-CLIP	22291592
MIRT496357	hsa-miR-29c-3p	PAR-CLIP	22291592
MIRT496356	hsa-miR-6871-3p	PAR-CLIP	22291592
MIRT496355	hsa-miR-3929	PAR-CLIP	22291592
MIRT496354	hsa-miR-4419b	PAR-CLIP	22291592
MIRT496353	hsa-miR-4478	PAR-CLIP	22291592
MIRT496352	hsa-miR-5682	PAR-CLIP	22291592

Gene ontology (GO) Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001664	Function	G protein-coupled receptor binding	IEA
GO:0001664	Function	G protein-coupled receptor binding	IPI	7493937, 7592911
GO:0005179	Function	Hormone activity	IEA
GO:0005179	Function	Hormone activity	TAS	2997153
GO:0005184	Function	Neuropeptide hormone activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007631	Process	Feeding behavior	IBA
GO:0009306	Process	Protein secretion	TAS	2997153
GO:0031841	Function	Neuropeptide Y receptor binding	IBA

Other IDs

• MIM: 167780
• HGNC: 9327
• e!Ensembl: ENSG00000108849

Protein

• UniProt ID: P01298
• Protein name: Pancreatic polypeptide prohormone (PH) (Pancreatic polypeptide Y) (Obinepitide) [Cleaved into: Pancreatic polypeptide (HPP) (PP); Pancreatic icosapeptide (PI)]
• Protein function: [Pancreatic polypeptide]: Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2. {ECO:0000269|PubMed:7493937, ECO:0000269|Pu
• PDB: 1TZ4 , 1TZ5 , 7X9C
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00159	Hormone_3	31 → 65	Pancreatic hormone peptide	Family

• Sequence:

  MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINML
  TRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL

• Sequence length: 95

Pathways

KEGG Pathway	Reactome Pathway
Neuroactive ligand-receptor interaction	Peptide ligand-binding receptors
	G alpha (i) signalling events

Related Genes

Sort by: Blended Diseases Pathways Evidence source

NPY4R2 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. CORT 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. NPB 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. GALR1 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. NPBWR1 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
NPY4R2	0	[]	2	["G alpha (i) signalling events","Peptide ligand-binding receptors"]	0	[]
CORT	0	[]	2	["G alpha (i) signalling events","Peptide ligand-binding receptors"]	0	[]
NPB	0	[]	2	["G alpha (i) signalling events","Peptide ligand-binding receptors"]	0	[]
GALR1	0	[]	2	["G alpha (i) signalling events","Peptide ligand-binding receptors"]	0	[]
NPBWR1	0	[]	2	["G alpha (i) signalling events","Peptide ligand-binding receptors"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 2 of 5 related genesGALR1, NPBWR1 Obesity Linked via 2 of 5 related genesGALR1, NPBWR1 Polycystic ovary syndrome Linked via 1 of 5 related genesNPB Atrophic macular degeneration Linked via 1 of 5 related genesGALR1 Behcet disease Linked via 1 of 5 related genesGALR1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	2	["GALR1","NPBWR1"]
Obesity	2	["GALR1","NPBWR1"]
Polycystic ovary syndrome	1	["NPB"]
Atrophic macular degeneration	1	["GALR1"]
Behcet disease	1	["GALR1"]