NPW (neuropeptide W)

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Gene Gene information from NCBI Gene database.
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Entrez ID 283869
Gene name Neuropeptide W
Gene symbol NPW
Synonyms (NCBI Gene)
L8L8CPPL8PPNPW
Chromosome 16
Chromosome location 16p13.3
Summary The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0001664 Function G protein-coupled receptor binding IBA
GO:0001664 Function G protein-coupled receptor binding IEA
GO:0005515 Function Protein binding IPI 12401809
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
607997 30509 ENSG00000183971
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N729
Protein name Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)]
Protein function Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15180 NPBW 15 → 129 Neuropeptides B and W Family
Tissue specificity TISSUE SPECIFICITY: Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and p
Sequence
Sequence length 165
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Neuroactive ligand-receptor interaction Peptide ligand-binding receptors
  G alpha (i) signalling events
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NPY4R2 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. CORT 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. NPB 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. GALR1 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors. NPBWR1 2 shared pathwaysG alpha (i) signalling events, Peptide ligand-binding receptors Related via 2 shared pathways including G alpha (i) signalling events, Peptide ligand-binding receptors.
Alzheimer disease Linked via 2 of 5 related genesGALR1, NPBWR1 Obesity Linked via 2 of 5 related genesGALR1, NPBWR1 Polycystic ovary syndrome Linked via 1 of 5 related genesNPB Atrophic macular degeneration Linked via 1 of 5 related genesGALR1 Behcet disease Linked via 1 of 5 related genesGALR1