MED22 (mediator complex subunit 22)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 6837 |
| Gene name | Mediator complex subunit 22 |
| Gene symbol | MED22 |
| Synonyms (NCBI Gene) |
MED24SRB6SURF5surf-5
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| Chromosome | 9 |
| Chromosome location | 9q34.2 |
| Summary | This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively splice |
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miRNA
miRNA information provided by mirtarbase database.
290
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q15528 | ||||||||||
| Protein name | Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5) | ||||||||||
| Protein function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN | ||||||||||
| PDB | 7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH | ||||||||||
| Family and domains |
Pfam
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| Sequence |
MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYE |
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| Sequence length | 200 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with MED22 across shared curated disease and pathway associations.
5
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to MED22 (see Related Genes above), that are NOT already directly curated for MED22 itself -- a lead worth checking, not a confirmed association.
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