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Gene Gene information from NCBI Gene database.
Entrez ID 6837
Gene name Mediator complex subunit 22
Gene symbol MED22
Synonyms (NCBI Gene)
MED24SRB6SURF5surf-5
Chromosome 9
Chromosome location 9q34.2
Summary This gene encodes a protein component of the mediator complex, which functions in the regulation of transcription by bridging interactions between gene-specific regulatory factors, RNA polymerase II, and general transcription factors. Alternatively splice
miRNA miRNA information provided by mirtarbase database.
290 Show/Hide all (290)
miRTarBase ID miRNA Experiments Reference
MIRT024383 hsa-miR-215-5p Microarray 19074876
MIRT026109 hsa-miR-192-5p Microarray 19074876
MIRT028841 hsa-miR-26b-5p Microarray 19088304
MIRT030376 hsa-miR-24-3p Microarray 19748357
MIRT045399 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity IEA
GO:0005515 Function Protein binding IPI 12584197, 14638676, 15175163, 24882805, 24981860, 32296183, 32814053, 33961781, 35271311
GO:0005634 Component Nucleus IDA 24882805
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
185641 11477 ENSG00000148297
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15528
Protein name Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)
Protein function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN
PDB 7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06179 Med22 20 → 125 Surfeit locus protein 5 subunit 22 of Mediator complex Family
Sequence
MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYE
MHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLR
DEISI
DLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGP
LQVAAPAHSHAGGPGPTEHA
Sequence length 200
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation