Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 9412
Gene name Mediator complex subunit 21
Gene symbol MED21
Synonyms (NCBI Gene)
SRB7SURB7hSrb7
Chromosome 12
Chromosome location 12p11.23
Summary This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene
miRNA miRNA information provided by mirtarbase database.
414 Show/Hide all (414)
miRTarBase ID miRNA Experiments Reference
MIRT048905 hsa-miR-93-5p CLASH 23622248
MIRT551778 hsa-miR-548n PAR-CLIP 21572407
MIRT551777 hsa-miR-548az-5p PAR-CLIP 21572407
MIRT551776 hsa-miR-548t-5p PAR-CLIP 21572407
MIRT551775 hsa-miR-548av-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22 Show/Hide all (22)
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IEA
GO:0001824 Process Blastocyst development IEA
GO:0003712 Function Transcription coregulator activity IBA
GO:0003713 Function Transcription coactivator activity IDA 12037571
GO:0003899 Function DNA-directed RNA polymerase activity TAS 8598913
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603800 11473 ENSG00000152944
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13503
Protein name Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)
Protein function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN
PDB 7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11221 Med21 1 → 127 Subunit 21 of Mediator complex Family
Sequence
Sequence length 144
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation