Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Evidence Score:★☆☆☆☆ Gene-disease association found in Text Mining only★★☆☆☆ Found in Text Mining and Unknown/Other Associations★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations
ClinVar entries with uncertain/conflicting evidence, and associations from other databases
(OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]
0
[]
Diseases Linked via Similar GenesDiseases curated for genes most similar to H3C8 (see Related Genes above), that are NOT already directly curated for H3C8 itself -- a lead worth checking, not a confirmed association.