H3C13 (H3 clustered histone 13)

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Gene Gene ontology Other IDs Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 653604
• Gene name: H3 clustered histone 13
• Gene symbol: H3C13
• Synonyms (NCBI Gene): H3C14, H3C15, HIST2H3D
• Chromosome: 1
• Chromosome location: 1q21.2
• Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	IEA
GO:0000786	Component	Nucleosome	IDA	21636898, 25615412
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	IPI	26694698
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	20580717, 21596426, 23075851, 26167883, 30021884, 32296183, 32814053, 33857403, 35271311
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	21636898
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	NAS	31790919
GO:0006334	Process	Nucleosome assembly	IDA	21636898, 25615412
GO:0010467	Process	Gene expression	IEA
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Interactions View interactions

Pathways

KEGG Pathway	Reactome Pathway
Neutrophil extracellular trap formation	Interleukin-7 signaling
Alcoholism	Formation of the beta-catenin:TCF transactivating complex
Shigellosis	PRC2 methylates histones and DNA
Transcriptional misregulation in cancer	Condensation of Prophase Chromosomes
Systemic lupus erythematosus	Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	HDACs deacetylate histones
	PKMTs methylate histone lysines
	HDMs demethylate histones
	HATs acetylate histones
	RMTs methylate histone arginines
	Chromatin modifying enzymes
	SIRT1 negatively regulates rRNA expression
	NoRC negatively regulates rRNA expression
	B-WICH complex positively regulates rRNA expression
	Transcriptional regulation by small RNAs
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
	RNA Polymerase I Promoter Opening
	RNA Polymerase I Promoter Escape
	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
	Estrogen-dependent gene expression
	HCMV Early Events
	HCMV Late Events
	Amyloid fiber formation
	Factors involved in megakaryocyte development and platelet production

Related Genes

Sort by: Blended Diseases Pathways Evidence source

H3C14 30 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Shigellosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Factors involved in megakaryocyte development and platelet production, Condensation of Prophase Chromosomes, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, HCMV Early Events, Senescence-Associated Secretory Phenotype (SASP) +18 more Related via 30 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H3C15 30 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Shigellosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Factors involved in megakaryocyte development and platelet production, Condensation of Prophase Chromosomes, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, HCMV Early Events, Senescence-Associated Secretory Phenotype (SASP) +18 more Related via 30 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H3C1 30 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Shigellosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Factors involved in megakaryocyte development and platelet production, Condensation of Prophase Chromosomes, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, HCMV Early Events, Senescence-Associated Secretory Phenotype (SASP) +18 more Related via 30 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H3C4 30 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Shigellosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Factors involved in megakaryocyte development and platelet production, Condensation of Prophase Chromosomes, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, HCMV Early Events, Senescence-Associated Secretory Phenotype (SASP) +18 more Related via 30 shared pathways including Neutrophil extracellular trap formation, Alcoholism. H3C3 30 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Shigellosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Factors involved in megakaryocyte development and platelet production, Condensation of Prophase Chromosomes, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, HCMV Early Events, Senescence-Associated Secretory Phenotype (SASP) +18 more Related via 30 shared pathways including Neutrophil extracellular trap formation, Alcoholism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
H3C14	0	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	0	[]
H3C15	0	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	0	[]
H3C1	0	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	0	[]
H3C4	0	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	0	[]
H3C3	0	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	0	[]

Diseases Linked via Similar Genes

Insomnia Linked via 1 of 5 related genesH3C4 Major depressive disorder Linked via 1 of 5 related genesH3C4 Schizophrenia Linked via 1 of 5 related genesH3C4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Insomnia	1	["H3C4"]
Major depressive disorder	1	["H3C4"]
Schizophrenia	1	["H3C4"]