Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	8968
Gene name	H3 clustered histone 7
Gene symbol	H3C7
Synonyms (NCBI Gene)	H3/iH3C1H3C10H3C11H3C12H3C2H3C3H3C4H3C6H3C8H3FIHIST1H3F
Chromosome	6
Chromosome location	6p22.2
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the f

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000786	Component	Nucleosome	IDA	14718166, 20498094, 21636898, 24699735, 25615412, 30867594
GO:0000786	Component	Nucleosome	IEA
GO:0000786	Component	Nucleosome	IPI	21812398, 24311584
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IDA	30867594
GO:0005515	Function	Protein binding	IPI	10949293, 10975519, 12540855, 16189514, 16246723, 16415788, 16603238, 16946699, 17157298, 18292755, 18418070, 19410544, 19498464, 19766566, 20080577, 20498094, 20541251, 20739937, 20871592, 21685874, 22720776, 23142979, 23275563, 24590075, 24606918, 24788516, 24981860, 25281560, 254
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	21636898, 22720776
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	NAS	31790919
GO:0006334	Process	Nucleosome assembly	IDA	14718166, 20498094, 21636898, 24699735
GO:0006334	Process	Nucleosome assembly	IMP	25615412
GO:0010467	Process	Gene expression	IDA	30867594
GO:0016020	Component	Membrane	HDA	19946888
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0040029	Process	Epigenetic regulation of gene expression	IDA	16267050
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

MIM	HGNC	e!Ensembl
602816	4773	ENSG00000277775

Interactions View interactions

KEGG Pathway	Reactome Pathway
Neutrophil extracellular trap formation	Interleukin-7 signaling
Alcoholism	Formation of the beta-catenin:TCF transactivating complex
Shigellosis	PRC2 methylates histones and DNA
Transcriptional misregulation in cancer	Condensation of Prophase Chromosomes
Systemic lupus erythematosus	Oxidative Stress Induced Senescence
	Senescence-Associated Secretory Phenotype (SASP)
	HDACs deacetylate histones
	PKMTs methylate histone lysines
	HDMs demethylate histones
	HATs acetylate histones
	RMTs methylate histone arginines
	Chromatin modifying enzymes
	SIRT1 negatively regulates rRNA expression
	NoRC negatively regulates rRNA expression
	B-WICH complex positively regulates rRNA expression
	Transcriptional regulation by small RNAs
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
	RNA Polymerase I Promoter Opening
	RNA Polymerase I Promoter Escape
	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
	Estrogen-dependent gene expression
	HCMV Early Events
	HCMV Late Events
	Amyloid fiber formation
	Factors involved in megakaryocyte development and platelet production

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
H3C14	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	[]
H3C15	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	[]
H3C13	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	[]
H3C1	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	[]
H3C4	[]	30	["Neutrophil extracellular trap formation","Alcoholism","Shigellosis","Transcriptional misregulation in cancer","Systemic lupus erythematosus","Factors involved in megakaryocyte development and platelet production","Condensation of Prophase Chromosomes","HCMV Late Events","Oxidative Stress Induced Senescence","Amyloid fiber formation","HCMV Early Events","Senescence-Associated Secretory Phenotype (SASP)"]	[]

H3C7 (H3 clustered histone 7)

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