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Gene Gene information from NCBI Gene database.
Entrez ID 2946
Gene name Glutathione S-transferase mu 2
Gene symbol GSTM2
Synonyms (NCBI Gene)
GST4GSTMGSTM2-2GTHMUS
Chromosome 1
Chromosome location 1p13.3
Summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omeg
miRNA miRNA information provided by mirtarbase database.
174 Show/Hide all (174)
miRTarBase ID miRNA Experiments Reference
MIRT023220 hsa-miR-122-5p Other 18692484
MIRT025057 hsa-miR-181a-5p Microarray 17612493
MIRT1036566 hsa-miR-2909 CLIP-seq
MIRT1036567 hsa-miR-3126-5p CLIP-seq
MIRT1036568 hsa-miR-3689a-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34 Show/Hide all (34)
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IDA 2034681, 8373352, 16549767
GO:0004364 Function Glutathione transferase activity IEA
GO:0004602 Function Glutathione peroxidase activity IDA 16624487
GO:0005504 Function Fatty acid binding IPI 16624487
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
138380 4634 ENSG00000213366
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P28161
Protein name Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2)
Protein function Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). {ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:21046276
PDB 1HNA , 1HNB , 1HNC , 1XW5 , 1YKC , 2AB6 , 2C4J , 2GTU , 3GTU , 3GUR , 5HWL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00043 GST_C 104 → 192 Glutathione S-transferase, C-terminal domain Domain
PF02798 GST_N 3 → 82 Glutathione S-transferase, N-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Muscle.
Sequence
Sequence length 218
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Glutathione metabolism Glutathione conjugation
Metabolism of xenobiotics by cytochrome P450  
Drug metabolism - cytochrome P450  
Drug metabolism - other enzymes  
Metabolic pathways  
Platinum drug resistance  
Pathways in cancer  
Chemical carcinogenesis - DNA adducts  
Chemical carcinogenesis - receptor activation  
Chemical carcinogenesis - reactive oxygen species  
Hepatocellular carcinoma  
Fluid shear stress and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (14)
Phenotype Name Clinical Significance Source Reference Evidence Score
BREAST CANCER — GWAS catalog 29059683, 32424353
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA — GWAS catalog 29059683, 32424353, 35803233
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG — CTD 19900515
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEGENERATIVE DISORDER — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DOWN SYNDROME — CTD, Disgenet
CTD, Disgenet
11771762
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (169)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Kidney Insufficiency Acute Kidney Insufficiency CTD_human_DG 20623750
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 12492580, 23707957
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22085405
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 34918636 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 18952980
★★★★★
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 21212706
★★★★★
★☆☆☆☆
Found in Text Mining only
Anal carcinoma Anal Cancer BEFREE 8959321
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 11500195
★★★★★
★☆☆☆☆
Found in Text Mining only
ARTHROGRYPOSIS, DISTAL, TYPE 2B Sheldon-Hall syndrome BEFREE 24004509
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 12186820, 16882827, 23647087
★★★★★
★☆☆☆☆
Found in Text Mining only