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Gene Gene information from NCBI Gene database.
Entrez ID 54331
Gene name G protein subunit gamma 2
Gene symbol GNG2
Synonyms (NCBI Gene)
HG3F1
Chromosome 14
Chromosome location 14q22.1
Summary This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provide
miRNA miRNA information provided by mirtarbase database.
257 Show/Hide all (257)
miRTarBase ID miRNA Experiments Reference
MIRT028498 hsa-miR-30a-5p Proteomics 18668040
MIRT715893 hsa-miR-16-1-3p HITS-CLIP 19536157
MIRT715892 hsa-miR-877-3p HITS-CLIP 19536157
MIRT715891 hsa-miR-942-5p HITS-CLIP 19536157
MIRT715890 hsa-miR-222-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22 Show/Hide all (22)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23739333, 28219978, 28437792, 32528175, 33961781, 35271311
GO:0005834 Component Heterotrimeric G-protein complex IBA
GO:0005834 Component Heterotrimeric G-protein complex IDA 29925951, 33762731, 34239069
GO:0005834 Component Heterotrimeric G-protein complex IEA
GO:0005834 Component Heterotrimeric G-protein complex ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606981 4404 ENSG00000186469
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P59768
Protein name Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems (PubMed:29925951, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:35714614, PubMed:35835867, PubMed:3
PDB 4KFM , 5HE0 , 5HE1 , 5HE2 , 5HE3 , 5UKK , 5UKL , 5UKM , 5UZ7 , 6B3J , 6CRK , 6D9H , 6DDE , 6DDF , 6E3Y , 6EG8 , 6G79 , 6GDG , 6K41 , 6K42 , 6KPF , 6KPG , 6LFM , 6LFO , 6LI3 , 6LMK , 6LML , 6M1H , 6M1I , 6M8S , 6N4B , 6NI3 , 6NIY , 6OIJ , 6OIK , 6OMM , 6ORV , 6OS9 , 6OSA , 6OT0 , 6P9X , 6P9Y , 6PB0 , 6PB1 , 6PT0 , 6UUN , 6UUS , 6UVA , 6VCB , 6VMS , 6VN7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00631 G-gamma 5 → 71 GGL domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain. {ECO:0000269|PubMed:10833460}.
Sequence
Sequence length 71
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ras signaling pathway Activation of G protein gated Potassium channels
Chemokine signaling pathway Glucagon signaling in metabolic regulation
Hormone signaling G-protein activation
PI3K-Akt signaling pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Apelin signaling pathway ADP signalling through P2Y purinoceptor 12
Circadian entrainment G beta:gamma signalling through PI3Kgamma
Retrograde endocannabinoid signaling Prostacyclin signalling through prostacyclin receptor
Glutamatergic synapse Adrenaline,noradrenaline inhibits insulin secretion
Cholinergic synapse Ca2+ pathway
Serotonergic synapse G alpha (q) signalling events
GABAergic synapse G alpha (12/13) signalling events
Dopaminergic synapse G beta:gamma signalling through PLC beta
Relaxin signaling pathway G alpha (s) signalling events
Morphine addiction ADP signalling through P2Y purinoceptor 1
Alcoholism G alpha (i) signalling events
Human cytomegalovirus infection G alpha (z) signalling events
Kaposi sarcoma-associated herpesvirus infection Glucagon-type ligand receptors
Human immunodeficiency virus 1 infection Thromboxane signalling through TP receptor
Pathways in cancer Vasopressin regulates renal water homeostasis via Aquaporins
  Thrombin signalling through proteinase activated receptors (PARs)
  Presynaptic function of Kainate receptors
  Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
  G beta:gamma signalling through BTK
  G beta:gamma signalling through CDC42
  Extra-nuclear estrogen signaling
  ADORA2B mediated anti-inflammatory cytokines production
  Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (7)
Phenotype Name Clinical Significance Source Reference Evidence Score
BREAST CANCER — GWAS catalog 29059683
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA — GWAS catalog 29059683
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE — GWAS catalog 25584925
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA — GWAS catalog 24658283
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (15)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 31730405
★★★★★
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial fibrillation Pubtator 34938350 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 35045088 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
IGA Glomerulonephritis Glomerulonephritis BEFREE 30928649
★★★★★
★☆☆☆☆
Found in Text Mining only
Impaired cognition Impaired Cognition GWASCAT_DG 26252872
★★★★★
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung neoplasms Pubtator 24658283 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 23031273
★★★★★
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple Sclerosis BEFREE 31790618
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Neuroblastoma Neuroblastoma Pubtator 31432180 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Pulmonary Arterial Hypertension Pulmonary arterial hypertension Pubtator 26252367 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only