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Gene Gene information from NCBI Gene database.
Entrez ID 55802
Gene name Decapping mRNA 1A
Gene symbol DCP1A
Synonyms (NCBI Gene)
HSA275986Nbla00360SMAD4IP1SMIF
Chromosome 3
Chromosome location 3p21.1
Summary Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may
miRNA miRNA information provided by mirtarbase database.
878 Show/Hide all (878)
miRTarBase ID miRNA Experiments Reference
MIRT024712 hsa-miR-215-5p Microarray 19074876
MIRT026897 hsa-miR-192-5p Microarray 19074876
MIRT031074 hsa-miR-21-5p Microarray 18372920
MIRT031074 hsa-miR-21-5p Microarray 18270520
MIRT031074 hsa-miR-21-5p Microarray 17991735
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
GO:0000932 Component P-body IBA
GO:0000932 Component P-body IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607010 18714 ENSG00000272886
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NPI6
Protein name mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF)
Protein function Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (Pu
PDB 2WX3 , 4B6H
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06058 DCP1 8 → 124 Dcp1-like decapping family Domain
PF16741 mRNA_decap_C 539 → 581 mRNA-decapping enzyme C-terminus Domain
Tissue specificity TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas. {ECO:0000269|PubMed:11836524}.
Sequence
MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRS
ASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAK
LMAD
VVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISS
PGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSE
EMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASIT
QSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPV
PELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVAS
FSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSS
AIPVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSI
ILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHN
L
Sequence length 582
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
RNA degradation mRNA decay by 5' to 3' exoribonuclease
  Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)