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Gene Gene information from NCBI Gene database.
Entrez ID 167227
Gene name Decapping mRNA 2
Gene symbol DCP2
Synonyms (NCBI Gene)
NUDT20
Chromosome 5
Chromosome location 5q22.2
Summary The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to
miRNA miRNA information provided by mirtarbase database.
2041 Show/Hide all (2041)
miRTarBase ID miRNA Experiments Reference
MIRT017959 hsa-miR-335-5p Microarray 18185580
MIRT019392 hsa-miR-148b-3p Microarray 17612493
MIRT021984 hsa-miR-128-3p Microarray 17612493
MIRT030494 hsa-miR-24-3p Microarray 19748357
MIRT048999 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31 Show/Hide all (31)
GO ID Ontology Definition Evidence Reference
GO:0000184 Process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
GO:0000290 Process Deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
GO:0000932 Component P-body IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609844 24452 ENSG00000172795
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IU60
Protein name m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)
Protein function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12218187, PubMed:12417715, PubMed:12923261, PubMed:21070968, PubMed:28002401, PubMed:31875550). Removes the 7-methyl guanine cap structure from mRNA molecu
PDB 5MP0 , 5QOH , 5QOI , 5QOJ , 5QOK , 5QOL , 5QOM , 5QON , 5QOO , 5QOP , 5QOQ , 5QOR , 5QOS , 5QOT , 5QOU , 5QOV , 5QOW , 5QOX , 5QOY , 5QOZ , 5QP0 , 5QP1 , 5QP2 , 5QP3 , 5QP4 , 5QP5 , 5QP6 , 5QP7 , 5QP8 , 5QP9 , 5QPA , 5QPB , 5QPC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00293 NUDIX 95 → 221 NUDIX domain Domain
PF05026 DCP2 11 → 93 Dcp2, box A domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in brain and testis. Not detected in heart (at protein level). {ECO:0000269|PubMed:21070968}.
Sequence
METKRVEIPGSVLDDLCSRFILHIPSEERDNAIRVCFQIELAHWFYLDFYMQNTPGLPQC
GIRDFAKAVFSHCPFLLPQGEDVEKVLDEWKEY
KMGVPTYGAIILDETLENVLLVQGYLA
KSGWGFPKGKVNKEEAPHDCAAREVFEETGFDIKDYICKDDYIELRINDQLARLYIIPGI
PKDTKFNPKTRREIRNIEWFSIEKLPCHRNDMTPKSKLGLA
PNKFFMAIPFIRPLRDWLS
RRFGDSSDSDNGFSSTGSTPAKPTVEKLSRTKFRHSQQLFPDGSPGDQWVKHRQPLQQKP
YNNHSEMSDLLKGKNQSMRGNGRKQYQDSPNQKKRTNGLQPAKQQNSLMKCEKKLHPRKL
QDNFETDAVYDLPSSSEDQLLEHAEGQPVACNGHCKFPFSSRAFLSFKFDHNAIMKILDL
Sequence length 420
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
RNA degradation ATF4 activates genes in response to endoplasmic reticulum stress
  mRNA decay by 5' to 3' exoribonuclease
  Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  KSRP (KHSRP) binds and destabilizes mRNA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Chronic lymphocytic leukemia/small lymphocytic lymphoma Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Heart Failure Heart failure Pubtator 36782329 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only