DIS3 (DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 22894
• Gene name: DIS3 exosome endoribonuclease and 3''-5'' exoribonuclease
• Gene symbol: DIS3
• Synonyms (NCBI Gene): 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p
• Chromosome: 13
• Chromosome location: 13q21.33

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1593835248	T>A	Likely-pathogenic	Coding sequence variant, missense variant

miRNA Show/Hide all (402)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022253	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT028852	hsa-miR-26b-5p	Microarray	19088304
MIRT047998	hsa-miR-30c-5p	CLASH	23622248
MIRT704221	hsa-miR-802	HITS-CLIP	23313552
MIRT645150	hsa-miR-1245a	HITS-CLIP	23824327
MIRT645149	hsa-miR-8079	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT645147	hsa-miR-4765	HITS-CLIP	23824327
MIRT645148	hsa-miR-640	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615035	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT615034	hsa-miR-4534	HITS-CLIP	23824327
MIRT615033	hsa-miR-8082	HITS-CLIP	23824327
MIRT615032	hsa-miR-450a-5p	HITS-CLIP	23824327
MIRT615031	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT610293	hsa-miR-4698	HITS-CLIP	23824327
MIRT610292	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT610291	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610290	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT575896	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT575896	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT575896	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT575896	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT575896	hsa-miR-150-5p	HITS-CLIP	28735896
MIRT575898	hsa-miR-186-3p	HITS-CLIP	28735896
MIRT575898	hsa-miR-186-3p	HITS-CLIP	28735896
MIRT575898	hsa-miR-186-3p	HITS-CLIP	28735896
MIRT575898	hsa-miR-186-3p	HITS-CLIP	28735896
MIRT575898	hsa-miR-186-3p	HITS-CLIP	28735896
MIRT575898	hsa-miR-186-3p	HITS-CLIP	28735896
MIRT610294	hsa-miR-3146	HITS-CLIP	28735896
MIRT610294	hsa-miR-3146	HITS-CLIP	28735896
MIRT610294	hsa-miR-3146	HITS-CLIP	28735896
MIRT610294	hsa-miR-3146	HITS-CLIP	28735896
MIRT610294	hsa-miR-3146	HITS-CLIP	28735896
MIRT575897	hsa-miR-4698	HITS-CLIP	28735896
MIRT575897	hsa-miR-4698	HITS-CLIP	28735896
MIRT575897	hsa-miR-4698	HITS-CLIP	28735896
MIRT575897	hsa-miR-4698	HITS-CLIP	28735896
MIRT575897	hsa-miR-4698	HITS-CLIP	28735896
MIRT575897	hsa-miR-4698	HITS-CLIP	28735896
MIRT575895	hsa-miR-640	HITS-CLIP	28735896
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	28735896
MIRT704221	hsa-miR-802	HITS-CLIP	23313552
MIRT645150	hsa-miR-1245a	HITS-CLIP	23824327
MIRT645149	hsa-miR-8079	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT645147	hsa-miR-4765	HITS-CLIP	23824327
MIRT575895	hsa-miR-640	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT615035	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT615034	hsa-miR-4534	HITS-CLIP	23824327
MIRT615033	hsa-miR-8082	HITS-CLIP	23824327
MIRT615032	hsa-miR-450a-5p	HITS-CLIP	23824327
MIRT615031	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT610294	hsa-miR-3146	HITS-CLIP	23824327
MIRT575897	hsa-miR-4698	HITS-CLIP	23824327
MIRT575898	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT575896	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT575894	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT937111	hsa-miR-1238	CLIP-seq
MIRT937112	hsa-miR-1273f	CLIP-seq
MIRT937113	hsa-miR-136	CLIP-seq
MIRT937114	hsa-miR-143	CLIP-seq
MIRT937115	hsa-miR-146b-3p	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT937117	hsa-miR-2681	CLIP-seq
MIRT937118	hsa-miR-298	CLIP-seq
MIRT937119	hsa-miR-3137	CLIP-seq
MIRT937120	hsa-miR-3158-5p	CLIP-seq
MIRT937121	hsa-miR-3180	CLIP-seq
MIRT937122	hsa-miR-3180-3p	CLIP-seq
MIRT937123	hsa-miR-3196	CLIP-seq
MIRT937124	hsa-miR-3646	CLIP-seq
MIRT937125	hsa-miR-3661	CLIP-seq
MIRT937126	hsa-miR-3662	CLIP-seq
MIRT937127	hsa-miR-3663-3p	CLIP-seq
MIRT937128	hsa-miR-3672	CLIP-seq
MIRT937129	hsa-miR-4268	CLIP-seq
MIRT937130	hsa-miR-4273	CLIP-seq
MIRT937131	hsa-miR-4448	CLIP-seq
MIRT937132	hsa-miR-4488	CLIP-seq
MIRT937133	hsa-miR-4496	CLIP-seq
MIRT937134	hsa-miR-4632	CLIP-seq
MIRT937135	hsa-miR-4658	CLIP-seq
MIRT937136	hsa-miR-4659a-3p	CLIP-seq
MIRT937137	hsa-miR-4659b-3p	CLIP-seq
MIRT937138	hsa-miR-4677-5p	CLIP-seq
MIRT937139	hsa-miR-4686	CLIP-seq
MIRT937140	hsa-miR-4691-5p	CLIP-seq
MIRT937141	hsa-miR-4697-5p	CLIP-seq
MIRT937142	hsa-miR-4708-5p	CLIP-seq
MIRT937143	hsa-miR-4722-3p	CLIP-seq
MIRT937144	hsa-miR-4753-3p	CLIP-seq
MIRT937145	hsa-miR-4758-5p	CLIP-seq
MIRT937146	hsa-miR-4770	CLIP-seq
MIRT937147	hsa-miR-4793-5p	CLIP-seq
MIRT937148	hsa-miR-493	CLIP-seq
MIRT937149	hsa-miR-561	CLIP-seq
MIRT937150	hsa-miR-628-5p	CLIP-seq
MIRT937151	hsa-miR-631	CLIP-seq
MIRT937152	hsa-miR-767-3p	CLIP-seq
MIRT937153	hsa-miR-942	CLIP-seq
MIRT937154	hsa-miR-1200	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT937155	hsa-miR-1912	CLIP-seq
MIRT937156	hsa-miR-1915	CLIP-seq
MIRT937157	hsa-miR-219-5p	CLIP-seq
MIRT937158	hsa-miR-24	CLIP-seq
MIRT937159	hsa-miR-410	CLIP-seq
MIRT937160	hsa-miR-4284	CLIP-seq
MIRT937161	hsa-miR-4324	CLIP-seq
MIRT937162	hsa-miR-4445	CLIP-seq
MIRT937163	hsa-miR-4634	CLIP-seq
MIRT937164	hsa-miR-4649-3p	CLIP-seq
MIRT937165	hsa-miR-4652-3p	CLIP-seq
MIRT937166	hsa-miR-4655-3p	CLIP-seq
MIRT937167	hsa-miR-4726-3p	CLIP-seq
MIRT937168	hsa-miR-4772-3p	CLIP-seq
MIRT937169	hsa-miR-4778-5p	CLIP-seq
MIRT937170	hsa-miR-4782-3p	CLIP-seq
MIRT937171	hsa-miR-4789-5p	CLIP-seq
MIRT937172	hsa-miR-508-3p	CLIP-seq
MIRT937173	hsa-miR-544b	CLIP-seq
MIRT937174	hsa-miR-595	CLIP-seq
MIRT1547975	hsa-miR-1245	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT1547976	hsa-miR-498	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT1547975	hsa-miR-1245	CLIP-seq
MIRT1921574	hsa-miR-3187-3p	CLIP-seq
MIRT1921575	hsa-miR-3663-5p	CLIP-seq
MIRT1921576	hsa-miR-371-5p	CLIP-seq
MIRT1921577	hsa-miR-371b-5p	CLIP-seq
MIRT1921578	hsa-miR-3913-3p	CLIP-seq
MIRT1921579	hsa-miR-411	CLIP-seq
MIRT1921580	hsa-miR-4435	CLIP-seq
MIRT1921581	hsa-miR-4701-5p	CLIP-seq
MIRT1921582	hsa-miR-4716-5p	CLIP-seq
MIRT1921583	hsa-miR-4755-3p	CLIP-seq
MIRT1921584	hsa-miR-4781-3p	CLIP-seq
MIRT1921585	hsa-miR-489	CLIP-seq
MIRT1921586	hsa-miR-548s	CLIP-seq
MIRT1921587	hsa-miR-588	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT937126	hsa-miR-3662	CLIP-seq
MIRT1977433	hsa-miR-556-3p	CLIP-seq
MIRT1547975	hsa-miR-1245	CLIP-seq
MIRT1977434	hsa-miR-1254	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT1977435	hsa-miR-190	CLIP-seq
MIRT1977436	hsa-miR-190b	CLIP-seq
MIRT1977437	hsa-miR-3116	CLIP-seq
MIRT1977438	hsa-miR-3144-5p	CLIP-seq
MIRT1977439	hsa-miR-3191	CLIP-seq
MIRT1977440	hsa-miR-4652-5p	CLIP-seq
MIRT1977441	hsa-miR-4667-5p	CLIP-seq
MIRT1977442	hsa-miR-4700-5p	CLIP-seq
MIRT937148	hsa-miR-493	CLIP-seq
MIRT1977443	hsa-miR-661	CLIP-seq
MIRT2212740	hsa-miR-122	CLIP-seq
MIRT1547975	hsa-miR-1245	CLIP-seq
MIRT2212741	hsa-miR-1281	CLIP-seq
MIRT2212742	hsa-miR-1307	CLIP-seq
MIRT937113	hsa-miR-136	CLIP-seq
MIRT2212743	hsa-miR-139-5p	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT937156	hsa-miR-1915	CLIP-seq
MIRT2212744	hsa-miR-1976	CLIP-seq
MIRT2212745	hsa-miR-3135b	CLIP-seq
MIRT2212746	hsa-miR-3652	CLIP-seq
MIRT937130	hsa-miR-4273	CLIP-seq
MIRT2212747	hsa-miR-4279	CLIP-seq
MIRT937160	hsa-miR-4284	CLIP-seq
MIRT2212748	hsa-miR-4302	CLIP-seq
MIRT2212749	hsa-miR-4430	CLIP-seq
MIRT2212750	hsa-miR-4638-5p	CLIP-seq
MIRT937138	hsa-miR-4677-5p	CLIP-seq
MIRT937143	hsa-miR-4722-3p	CLIP-seq
MIRT937167	hsa-miR-4726-3p	CLIP-seq
MIRT937168	hsa-miR-4772-3p	CLIP-seq
MIRT1547976	hsa-miR-498	CLIP-seq
MIRT2212751	hsa-miR-668	CLIP-seq
MIRT2212752	hsa-miR-718	CLIP-seq
MIRT2212753	hsa-miR-891b	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT2386914	hsa-miR-3170	CLIP-seq
MIRT2386915	hsa-miR-4260	CLIP-seq
MIRT2386916	hsa-miR-4274	CLIP-seq
MIRT2386917	hsa-miR-4519	CLIP-seq
MIRT937136	hsa-miR-4659a-3p	CLIP-seq
MIRT937137	hsa-miR-4659b-3p	CLIP-seq
MIRT2386918	hsa-miR-4760-5p	CLIP-seq
MIRT937154	hsa-miR-1200	CLIP-seq
MIRT2212740	hsa-miR-122	CLIP-seq
MIRT937111	hsa-miR-1238	CLIP-seq
MIRT937112	hsa-miR-1273f	CLIP-seq
MIRT2212741	hsa-miR-1281	CLIP-seq
MIRT937114	hsa-miR-143	CLIP-seq
MIRT937116	hsa-miR-150	CLIP-seq
MIRT937156	hsa-miR-1915	CLIP-seq
MIRT2212744	hsa-miR-1976	CLIP-seq
MIRT2516550	hsa-miR-2115	CLIP-seq
MIRT2516551	hsa-miR-2277-3p	CLIP-seq
MIRT937158	hsa-miR-24	CLIP-seq
MIRT2212745	hsa-miR-3135b	CLIP-seq
MIRT937119	hsa-miR-3137	CLIP-seq
MIRT937124	hsa-miR-3646	CLIP-seq
MIRT2212746	hsa-miR-3652	CLIP-seq
MIRT937126	hsa-miR-3662	CLIP-seq
MIRT937127	hsa-miR-3663-3p	CLIP-seq
MIRT2516552	hsa-miR-3675-5p	CLIP-seq
MIRT1921578	hsa-miR-3913-3p	CLIP-seq
MIRT2516553	hsa-miR-3977	CLIP-seq
MIRT937129	hsa-miR-4268	CLIP-seq
MIRT937130	hsa-miR-4273	CLIP-seq
MIRT2212747	hsa-miR-4279	CLIP-seq
MIRT2516554	hsa-miR-4282	CLIP-seq
MIRT937160	hsa-miR-4284	CLIP-seq
MIRT2516555	hsa-miR-4311	CLIP-seq
MIRT937161	hsa-miR-4324	CLIP-seq
MIRT2516556	hsa-miR-4326	CLIP-seq
MIRT2212749	hsa-miR-4430	CLIP-seq
MIRT937162	hsa-miR-4445	CLIP-seq
MIRT937131	hsa-miR-4448	CLIP-seq
MIRT937133	hsa-miR-4496	CLIP-seq
MIRT937163	hsa-miR-4634	CLIP-seq
MIRT937138	hsa-miR-4677-5p	CLIP-seq
MIRT937139	hsa-miR-4686	CLIP-seq
MIRT937142	hsa-miR-4708-5p	CLIP-seq
MIRT937143	hsa-miR-4722-3p	CLIP-seq
MIRT937167	hsa-miR-4726-3p	CLIP-seq
MIRT937146	hsa-miR-4770	CLIP-seq
MIRT937168	hsa-miR-4772-3p	CLIP-seq
MIRT2516557	hsa-miR-4799-5p	CLIP-seq
MIRT1921585	hsa-miR-489	CLIP-seq
MIRT1547976	hsa-miR-498	CLIP-seq
MIRT2516558	hsa-miR-502-5p	CLIP-seq
MIRT2516559	hsa-miR-520d-5p	CLIP-seq
MIRT2516560	hsa-miR-524-5p	CLIP-seq
MIRT937173	hsa-miR-544b	CLIP-seq
MIRT937149	hsa-miR-561	CLIP-seq
MIRT2516561	hsa-miR-600	CLIP-seq
MIRT2212752	hsa-miR-718	CLIP-seq
MIRT937152	hsa-miR-767-3p	CLIP-seq
MIRT2212753	hsa-miR-891b	CLIP-seq
MIRT937154	hsa-miR-1200	CLIP-seq
MIRT2212740	hsa-miR-122	CLIP-seq
MIRT937111	hsa-miR-1238	CLIP-seq
MIRT2212741	hsa-miR-1281	CLIP-seq
MIRT937156	hsa-miR-1915	CLIP-seq
MIRT2212744	hsa-miR-1976	CLIP-seq
MIRT2516550	hsa-miR-2115	CLIP-seq
MIRT2516551	hsa-miR-2277-3p	CLIP-seq
MIRT937158	hsa-miR-24	CLIP-seq
MIRT2212745	hsa-miR-3135b	CLIP-seq
MIRT937119	hsa-miR-3137	CLIP-seq
MIRT2212746	hsa-miR-3652	CLIP-seq
MIRT1921578	hsa-miR-3913-3p	CLIP-seq
MIRT2516553	hsa-miR-3977	CLIP-seq
MIRT937130	hsa-miR-4273	CLIP-seq
MIRT2212747	hsa-miR-4279	CLIP-seq
MIRT2516554	hsa-miR-4282	CLIP-seq
MIRT937160	hsa-miR-4284	CLIP-seq
MIRT2516555	hsa-miR-4311	CLIP-seq
MIRT937161	hsa-miR-4324	CLIP-seq
MIRT2516556	hsa-miR-4326	CLIP-seq
MIRT2212749	hsa-miR-4430	CLIP-seq
MIRT937162	hsa-miR-4445	CLIP-seq
MIRT937133	hsa-miR-4496	CLIP-seq
MIRT937163	hsa-miR-4634	CLIP-seq
MIRT937138	hsa-miR-4677-5p	CLIP-seq
MIRT937143	hsa-miR-4722-3p	CLIP-seq
MIRT937167	hsa-miR-4726-3p	CLIP-seq
MIRT937168	hsa-miR-4772-3p	CLIP-seq
MIRT2516557	hsa-miR-4799-5p	CLIP-seq
MIRT1921585	hsa-miR-489	CLIP-seq
MIRT1547976	hsa-miR-498	CLIP-seq
MIRT2516558	hsa-miR-502-5p	CLIP-seq
MIRT937173	hsa-miR-544b	CLIP-seq
MIRT2212752	hsa-miR-718	CLIP-seq
MIRT2212753	hsa-miR-891b	CLIP-seq

Gene ontology (GO) Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IBA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IEA
GO:0000175	Function	3'-5'-RNA exonuclease activity	IMP	20531386
GO:0000175	Function	3'-5'-RNA exonuclease activity	TAS
GO:0000176	Component	Nuclear exosome (RNase complex)	IBA
GO:0000176	Component	Nuclear exosome (RNase complex)	IDA	20531386
GO:0000176	Component	Nuclear exosome (RNase complex)	IEA
GO:0000176	Component	Nuclear exosome (RNase complex)	NAS	20531386
GO:0000177	Component	Cytoplasmic exosome (RNase complex)	IBA
GO:0000178	Component	Exosome (RNase complex)	IEA
GO:0000178	Component	Exosome (RNase complex)	NAS	20531386
GO:0000178	Component	Exosome (RNase complex)	TAS	9562621
GO:0000288	Process	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	TAS
GO:0000956	Process	Nuclear-transcribed mRNA catabolic process	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IBA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IMP	20531386
GO:0004527	Function	Exonuclease activity	IEA
GO:0004540	Function	RNA nuclease activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	9562621
GO:0005515	Function	Protein binding	IPI	15231747, 20531386, 20531389, 21255825, 23756462, 25220460, 33961781
GO:0005634	Component	Nucleus	IDA	20531386
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	20531389
GO:0005654	Component	Nucleoplasm	IEA
GO:0005730	Component	Nucleolus	IDA	20531386
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	20531386
GO:0005829	Component	Cytosol	TAS
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	TAS	9562621
GO:0006396	Process	RNA processing	IDA	17174896
GO:0006401	Process	RNA catabolic process	IDA	17174896
GO:0016020	Component	Membrane	HDA	19946888
GO:0016075	Process	RRNA catabolic process	IBA
GO:0016075	Process	RRNA catabolic process	IEA
GO:0016075	Process	RRNA catabolic process	IMP	20368444
GO:0016787	Function	Hydrolase activity	IEA
GO:0071031	Process	Nuclear mRNA surveillance of mRNA 3'-end processing	IBA
GO:0071034	Process	CUT catabolic process	IEA
GO:0071034	Process	CUT catabolic process	IMP	19056938

Other IDs

• MIM: 607533
• HGNC: 20604
• e!Ensembl: ENSG00000083520

Protein

• UniProt ID: Q9Y2L1
• Protein name: Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)
• Protein function: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper ma
• PDB: 6D6Q , 6D6R , 6H25
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13638	PIN_4	66 → 195	PIN domain	Domain
  PF17215	Rrp44_S1	846 → 925	S1 domain	Domain
  PF17216	Rrp44_CSD1	225 → 351	Rrp44-like cold shock domain	Domain
  PF17849	OB_Dis3	370 → 438	Dis3-like cold-shock domain 2 (CSD2)	Domain
  PF00773	RNB	467 → 797	RNB domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed.
• Sequence:

  MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHEGPALEPQPQDPASSVC
  PQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRSAPVYKRIRDVTNNQEKHF
  YTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHLKKMSADNQLQVIFITNDRRN
  KEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEGNEIESGKIIFSEHLPLSKLQQG
  IKSGTYLQGTFRASRENYLEATVWIHGDNEENKEIILQGLKHLNRAVHEDIVAVELLPKS
  QWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKMLKPTGRVVGIIKRNWRPYCGML
  SKSDIKESRRHLFTPADKRIPRIRIETRQASTLEGRRIIVAIDGWPRNSRYPNGHFVRNL
  GDVGEKETETEVLLLEHDVPHQPFSQAVLSFLPKMPWSITEKDMKNREDLRHLCICSVDP
  PGCTDIDDALHCRELENGNLEVGVHIADVSHFIRPGNALDQESARRGTTVYLCEKRIDMV
  PELLSSNLCSLKCDVDRLAFSCIWEMNHNAEILKTKFTKSVINSKASLTYAEAQLRIDSA
  NMNDDITTSLRGLNKLAKILKKRRIEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETN
  SMVEEFMLLANISVAKKIHEEFSEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKS
  LAESLDQAESPTFPYLNTLLRILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIR
  RYADVIVHRLLAVAIGADCTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFF
  KSKGIVSEEAYILFVRKNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTV
  FHVFDKVKVKIMLDSSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK

• Sequence length: 958

Pathways

KEGG Pathway	Reactome Pathway
RNA degradation	ATF4 activates genes in response to endoplasmic reticulum stress
	mRNA decay by 3' to 5' exoribonuclease
	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
	KSRP (KHSRP) binds and destabilizes mRNA
	Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Multiple myeloma	Likely pathogenic	rs1593835248	RCV000984121	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
DIS3-related disorder	Benign; Conflicting classifications of pathogenicity; Uncertain significance; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Perlman syndrome	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	34290314	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	34290314	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (15)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenoma	Adenoma	BEFREE	24478024		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39408874	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	24478024		★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	23551967	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	24478024		★☆☆☆☆ Found in Text Mining only
Congenital chromosomal disease	Congenital Chromosomal Disease	BEFREE	30257227		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	34343137	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26193331, 29802118		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	21343389	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	24434212, 25521164, 26193331, 26305418, 29802118, 31768969		★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Multiple Myeloma	Multiple myeloma	Pubtator	24434212, 25521164, 25743686, 26305418, 27223072, 28550183, 29563506, 29802118, 29884741, 31988198, 33338886, 33951891, 36215697, 37439377, 37452600	Associate	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neoplasms	Neoplasms	BEFREE	25521164, 26305418		★☆☆☆☆ Found in Text Mining only
Nephroblastomatosis, fetal ascites, macrosomia and Wilms tumor	Perlman syndrome	BEFREE	22306653		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	28172817	Associate	★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Wilms tumor	Pubtator	35617957	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

EXOSC8 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC6 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC7 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC2 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC3 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
EXOSC8	0	[]	7	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol","mRNA decay by 3' to 5' exoribonuclease","ATF4 activates genes in response to endoplasmic reticulum stress","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA","KSRP (KHSRP) binds and destabilizes mRNA"]	0	[]
EXOSC6	0	[]	7	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol","mRNA decay by 3' to 5' exoribonuclease","ATF4 activates genes in response to endoplasmic reticulum stress","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA","KSRP (KHSRP) binds and destabilizes mRNA"]	0	[]
EXOSC7	0	[]	7	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol","mRNA decay by 3' to 5' exoribonuclease","ATF4 activates genes in response to endoplasmic reticulum stress","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA","KSRP (KHSRP) binds and destabilizes mRNA"]	0	[]
EXOSC2	0	[]	7	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol","mRNA decay by 3' to 5' exoribonuclease","ATF4 activates genes in response to endoplasmic reticulum stress","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA","KSRP (KHSRP) binds and destabilizes mRNA"]	0	[]
EXOSC3	0	[]	7	["RNA degradation","Major pathway of rRNA processing in the nucleolus and cytosol","mRNA decay by 3' to 5' exoribonuclease","ATF4 activates genes in response to endoplasmic reticulum stress","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA","KSRP (KHSRP) binds and destabilizes mRNA"]	0	[]

Diseases Linked via Similar Genes

Congenital pontocerebellar hypoplasia Linked via 2 of 5 related genesEXOSC8, EXOSC3 Pontocerebellar hypoplasia Linked via 2 of 5 related genesEXOSC8, EXOSC3 Spastic ataxia Linked via 1 of 5 related genesEXOSC8 Color vision deficiency Linked via 1 of 5 related genesEXOSC2 Liver neoplasms Linked via 1 of 5 related genesEXOSC2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Congenital pontocerebellar hypoplasia	2	["EXOSC8","EXOSC3"]
Pontocerebellar hypoplasia	2	["EXOSC8","EXOSC3"]
Spastic ataxia	1	["EXOSC8"]
Color vision deficiency	1	["EXOSC2"]
Liver neoplasms	1	["EXOSC2"]