EXOSC7 (exosome component 7)

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Gene Gene information from NCBI Gene database.
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Entrez ID 23016
Gene name Exosome component 7
Gene symbol EXOSC7
Synonyms (NCBI Gene)
EAP1RRP42Rrp42phRrp42pp8
Chromosome 3
Chromosome location 3p21.31
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39 Show/Hide all (39)
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GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-RNA exonuclease activity TAS 11849973
GO:0000176 Component Nuclear exosome (RNase complex) IBA
GO:0000176 Component Nuclear exosome (RNase complex) NAS 20531386
GO:0000177 Component Cytoplasmic exosome (RNase complex) IBA
GO:0000177 Component Cytoplasmic exosome (RNase complex) NAS 20531386
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
606488 28112 ENSG00000075914
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15024
Protein name Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8)
Protein function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturat
PDB 2NN6 , 6D6Q , 6D6R , 6H25 , 9G8M , 9G8N , 9G8O , 9G8P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01138 RNase_PH 31 → 166 Domain
PF03725 RNase_PH_C 196 → 262 Domain
Sequence 
MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
ELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMR
KVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
Sequence length 291
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
RNA degradation ATF4 activates genes in response to endoplasmic reticulum stress
  mRNA decay by 3' to 5' exoribonuclease
  Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  KSRP (KHSRP) binds and destabilizes mRNA
  Major pathway of rRNA processing in the nucleolus and cytosol
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EXOSC8 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC6 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. DIS3 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC2 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol. EXOSC3 7 shared pathwaysRNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol, mRNA decay by 3' to 5' exoribonuclease, ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, KSRP (KHSRP) binds and destabilizes mRNA Related via 7 shared pathways including RNA degradation, Major pathway of rRNA processing in the nucleolus and cytosol.
Congenital pontocerebellar hypoplasia Linked via 2 of 5 related genesEXOSC8, EXOSC3 Pontocerebellar hypoplasia Linked via 2 of 5 related genesEXOSC8, EXOSC3 Spastic ataxia Linked via 1 of 5 related genesEXOSC8 Prostate cancer Linked via 1 of 5 related genesDIS3 Color vision deficiency Linked via 1 of 5 related genesEXOSC2