CNOT8 (CCR4-NOT transcription complex subunit 8)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9337
• Gene name: CCR4-NOT transcription complex subunit 8
• Gene symbol: CNOT8
• Synonyms (NCBI Gene): CAF1, CALIF, Caf1b, POP2, hCAF1
• Chromosome: 5
• Chromosome location: 5q33.2

miRNA Show/Hide all (221)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004058	hsa-miR-7-5p	Microarray	19073608
MIRT004058	hsa-miR-7-5p	Sequencing	20371350
MIRT004058	hsa-miR-7-5p	Microarray;Other	19073608
MIRT051367	hsa-let-7f-5p	CLASH	23622248
MIRT041088	hsa-miR-504-5p	CLASH	23622248
MIRT901102	hsa-miR-1207-3p	CLIP-seq
MIRT901103	hsa-miR-1273d	CLIP-seq
MIRT901104	hsa-miR-1283	CLIP-seq
MIRT901105	hsa-miR-1298	CLIP-seq
MIRT901106	hsa-miR-2110	CLIP-seq
MIRT901107	hsa-miR-2467-5p	CLIP-seq
MIRT901108	hsa-miR-3150b-3p	CLIP-seq
MIRT901109	hsa-miR-3591-3p	CLIP-seq
MIRT901110	hsa-miR-3614-5p	CLIP-seq
MIRT901111	hsa-miR-3647-3p	CLIP-seq
MIRT901112	hsa-miR-3682-5p	CLIP-seq
MIRT901113	hsa-miR-371b-5p	CLIP-seq
MIRT901114	hsa-miR-375	CLIP-seq
MIRT901115	hsa-miR-3915	CLIP-seq
MIRT901116	hsa-miR-3923	CLIP-seq
MIRT901117	hsa-miR-3928	CLIP-seq
MIRT901118	hsa-miR-4251	CLIP-seq
MIRT901119	hsa-miR-4271	CLIP-seq
MIRT901120	hsa-miR-4292	CLIP-seq
MIRT901121	hsa-miR-4302	CLIP-seq
MIRT901122	hsa-miR-4308	CLIP-seq
MIRT901123	hsa-miR-4432	CLIP-seq
MIRT901124	hsa-miR-4446-5p	CLIP-seq
MIRT901125	hsa-miR-4511	CLIP-seq
MIRT901126	hsa-miR-4687-5p	CLIP-seq
MIRT901127	hsa-miR-4696	CLIP-seq
MIRT901128	hsa-miR-4699-3p	CLIP-seq
MIRT901129	hsa-miR-4725-3p	CLIP-seq
MIRT901130	hsa-miR-4755-5p	CLIP-seq
MIRT901131	hsa-miR-4784	CLIP-seq
MIRT901132	hsa-miR-4797-3p	CLIP-seq
MIRT901133	hsa-miR-520d-5p	CLIP-seq
MIRT901134	hsa-miR-520g	CLIP-seq
MIRT901135	hsa-miR-520h	CLIP-seq
MIRT901136	hsa-miR-524-5p	CLIP-seq
MIRT901137	hsa-miR-544	CLIP-seq
MIRT901138	hsa-miR-548b-3p	CLIP-seq
MIRT901139	hsa-miR-548c-3p	CLIP-seq
MIRT901140	hsa-miR-550b	CLIP-seq
MIRT901141	hsa-miR-580	CLIP-seq
MIRT901142	hsa-miR-648	CLIP-seq
MIRT901143	hsa-miR-660	CLIP-seq
MIRT901144	hsa-miR-664	CLIP-seq
MIRT901145	hsa-miR-670	CLIP-seq
MIRT901146	hsa-miR-671-5p	CLIP-seq
MIRT901147	hsa-miR-7	CLIP-seq
MIRT901148	hsa-miR-759	CLIP-seq
MIRT901149	hsa-miR-767-3p	CLIP-seq
MIRT901150	hsa-miR-885-5p	CLIP-seq
MIRT1967295	hsa-miR-1183	CLIP-seq
MIRT1967296	hsa-miR-1299	CLIP-seq
MIRT1967297	hsa-miR-203	CLIP-seq
MIRT1967298	hsa-miR-205	CLIP-seq
MIRT901106	hsa-miR-2110	CLIP-seq
MIRT1967299	hsa-miR-2355-3p	CLIP-seq
MIRT1967300	hsa-miR-3145-3p	CLIP-seq
MIRT1967301	hsa-miR-3150a-3p	CLIP-seq
MIRT1967302	hsa-miR-3613-3p	CLIP-seq
MIRT1967303	hsa-miR-3671	CLIP-seq
MIRT901116	hsa-miR-3923	CLIP-seq
MIRT1967304	hsa-miR-3942-3p	CLIP-seq
MIRT901119	hsa-miR-4271	CLIP-seq
MIRT1967305	hsa-miR-4328	CLIP-seq
MIRT901123	hsa-miR-4432	CLIP-seq
MIRT1967306	hsa-miR-4494	CLIP-seq
MIRT1967307	hsa-miR-4528	CLIP-seq
MIRT1967308	hsa-miR-4653-3p	CLIP-seq
MIRT901128	hsa-miR-4699-3p	CLIP-seq
MIRT901129	hsa-miR-4725-3p	CLIP-seq
MIRT1967309	hsa-miR-4753-3p	CLIP-seq
MIRT1967310	hsa-miR-4768-5p	CLIP-seq
MIRT1967311	hsa-miR-4782-5p	CLIP-seq
MIRT1967312	hsa-miR-499a-5p	CLIP-seq
MIRT1967313	hsa-miR-505	CLIP-seq
MIRT1967314	hsa-miR-516b	CLIP-seq
MIRT901140	hsa-miR-550b	CLIP-seq
MIRT1967315	hsa-miR-607	CLIP-seq
MIRT1967316	hsa-miR-634	CLIP-seq
MIRT1967317	hsa-miR-635	CLIP-seq
MIRT1967318	hsa-miR-676	CLIP-seq
MIRT901147	hsa-miR-7	CLIP-seq
MIRT2202937	hsa-miR-1276	CLIP-seq
MIRT901104	hsa-miR-1283	CLIP-seq
MIRT2202938	hsa-miR-1972	CLIP-seq
MIRT2202939	hsa-miR-200b	CLIP-seq
MIRT2202940	hsa-miR-200c	CLIP-seq
MIRT2202941	hsa-miR-21	CLIP-seq
MIRT901106	hsa-miR-2110	CLIP-seq
MIRT2202942	hsa-miR-29a	CLIP-seq
MIRT2202943	hsa-miR-29b	CLIP-seq
MIRT2202944	hsa-miR-29c	CLIP-seq
MIRT2202945	hsa-miR-3065-3p	CLIP-seq
MIRT1967301	hsa-miR-3150a-3p	CLIP-seq
MIRT2202946	hsa-miR-3192	CLIP-seq
MIRT2202947	hsa-miR-326	CLIP-seq
MIRT2202948	hsa-miR-330-5p	CLIP-seq
MIRT1967303	hsa-miR-3671	CLIP-seq
MIRT2202949	hsa-miR-369-3p	CLIP-seq
MIRT2202950	hsa-miR-374a	CLIP-seq
MIRT2202951	hsa-miR-374b	CLIP-seq
MIRT2202952	hsa-miR-380	CLIP-seq
MIRT2202953	hsa-miR-4263	CLIP-seq
MIRT901119	hsa-miR-4271	CLIP-seq
MIRT2202954	hsa-miR-429	CLIP-seq
MIRT2202955	hsa-miR-4291	CLIP-seq
MIRT2202956	hsa-miR-4311	CLIP-seq
MIRT2202957	hsa-miR-4314	CLIP-seq
MIRT1967305	hsa-miR-4328	CLIP-seq
MIRT901123	hsa-miR-4432	CLIP-seq
MIRT2202958	hsa-miR-4495	CLIP-seq
MIRT2202959	hsa-miR-450b-3p	CLIP-seq
MIRT2202960	hsa-miR-4517	CLIP-seq
MIRT2202961	hsa-miR-4646-5p	CLIP-seq
MIRT2202962	hsa-miR-4650-5p	CLIP-seq
MIRT2202963	hsa-miR-4672	CLIP-seq
MIRT901128	hsa-miR-4699-3p	CLIP-seq
MIRT2202964	hsa-miR-4713-3p	CLIP-seq
MIRT901129	hsa-miR-4725-3p	CLIP-seq
MIRT1967309	hsa-miR-4753-3p	CLIP-seq
MIRT2202965	hsa-miR-4760-3p	CLIP-seq
MIRT1967310	hsa-miR-4768-5p	CLIP-seq
MIRT2202966	hsa-miR-4772-5p	CLIP-seq
MIRT2202967	hsa-miR-489	CLIP-seq
MIRT2202968	hsa-miR-513a-3p	CLIP-seq
MIRT901133	hsa-miR-520d-5p	CLIP-seq
MIRT901136	hsa-miR-524-5p	CLIP-seq
MIRT2202969	hsa-miR-548t	CLIP-seq
MIRT2202970	hsa-miR-576-5p	CLIP-seq
MIRT2202971	hsa-miR-579	CLIP-seq
MIRT2202972	hsa-miR-583	CLIP-seq
MIRT2202973	hsa-miR-587	CLIP-seq
MIRT2202974	hsa-miR-590-5p	CLIP-seq
MIRT1967315	hsa-miR-607	CLIP-seq
MIRT1967316	hsa-miR-634	CLIP-seq
MIRT1967317	hsa-miR-635	CLIP-seq
MIRT2202975	hsa-miR-638	CLIP-seq
MIRT901144	hsa-miR-664	CLIP-seq
MIRT901147	hsa-miR-7	CLIP-seq
MIRT2202976	hsa-miR-769-3p	CLIP-seq
MIRT2447339	hsa-miR-3145-5p	CLIP-seq
MIRT2447340	hsa-miR-4648	CLIP-seq
MIRT2447341	hsa-miR-4654	CLIP-seq
MIRT2447342	hsa-miR-4769-5p	CLIP-seq
MIRT2447343	hsa-miR-508-5p	CLIP-seq
MIRT2505790	hsa-miR-105	CLIP-seq
MIRT1967296	hsa-miR-1299	CLIP-seq
MIRT1967298	hsa-miR-205	CLIP-seq
MIRT1967299	hsa-miR-2355-3p	CLIP-seq
MIRT2505791	hsa-miR-3126-3p	CLIP-seq
MIRT2505792	hsa-miR-3132	CLIP-seq
MIRT2505793	hsa-miR-3140-3p	CLIP-seq
MIRT1967300	hsa-miR-3145-3p	CLIP-seq
MIRT2505794	hsa-miR-3179	CLIP-seq
MIRT2505795	hsa-miR-3529	CLIP-seq
MIRT2505796	hsa-miR-3545-5p	CLIP-seq
MIRT2505797	hsa-miR-3663-5p	CLIP-seq
MIRT1967303	hsa-miR-3671	CLIP-seq
MIRT2505798	hsa-miR-379	CLIP-seq
MIRT901116	hsa-miR-3923	CLIP-seq
MIRT1967304	hsa-miR-3942-3p	CLIP-seq
MIRT2505799	hsa-miR-3977	CLIP-seq
MIRT2505800	hsa-miR-4276	CLIP-seq
MIRT2505801	hsa-miR-4282	CLIP-seq
MIRT1967305	hsa-miR-4328	CLIP-seq
MIRT1967306	hsa-miR-4494	CLIP-seq
MIRT1967307	hsa-miR-4528	CLIP-seq
MIRT1967308	hsa-miR-4653-3p	CLIP-seq
MIRT2505802	hsa-miR-4762-5p	CLIP-seq
MIRT1967311	hsa-miR-4782-5p	CLIP-seq
MIRT2505803	hsa-miR-490-5p	CLIP-seq
MIRT1967312	hsa-miR-499a-5p	CLIP-seq
MIRT1967313	hsa-miR-505	CLIP-seq
MIRT2202968	hsa-miR-513a-3p	CLIP-seq
MIRT1967314	hsa-miR-516b	CLIP-seq
MIRT901139	hsa-miR-548c-3p	CLIP-seq
MIRT2505804	hsa-miR-549	CLIP-seq
MIRT901140	hsa-miR-550b	CLIP-seq
MIRT1967315	hsa-miR-607	CLIP-seq
MIRT2505805	hsa-miR-665	CLIP-seq
MIRT1967318	hsa-miR-676	CLIP-seq
MIRT1967296	hsa-miR-1299	CLIP-seq
MIRT1967298	hsa-miR-205	CLIP-seq
MIRT1967299	hsa-miR-2355-3p	CLIP-seq
MIRT2202945	hsa-miR-3065-3p	CLIP-seq
MIRT2505791	hsa-miR-3126-3p	CLIP-seq
MIRT2505792	hsa-miR-3132	CLIP-seq
MIRT2505793	hsa-miR-3140-3p	CLIP-seq
MIRT1967300	hsa-miR-3145-3p	CLIP-seq
MIRT2505794	hsa-miR-3179	CLIP-seq
MIRT2505795	hsa-miR-3529	CLIP-seq
MIRT2505796	hsa-miR-3545-5p	CLIP-seq
MIRT2505797	hsa-miR-3663-5p	CLIP-seq
MIRT1967303	hsa-miR-3671	CLIP-seq
MIRT2505798	hsa-miR-379	CLIP-seq
MIRT901116	hsa-miR-3923	CLIP-seq
MIRT1967304	hsa-miR-3942-3p	CLIP-seq
MIRT2505799	hsa-miR-3977	CLIP-seq
MIRT2505800	hsa-miR-4276	CLIP-seq
MIRT2505801	hsa-miR-4282	CLIP-seq
MIRT2202955	hsa-miR-4291	CLIP-seq
MIRT1967305	hsa-miR-4328	CLIP-seq
MIRT1967306	hsa-miR-4494	CLIP-seq
MIRT1967307	hsa-miR-4528	CLIP-seq
MIRT1967308	hsa-miR-4653-3p	CLIP-seq
MIRT2505802	hsa-miR-4762-5p	CLIP-seq
MIRT1967311	hsa-miR-4782-5p	CLIP-seq
MIRT1967312	hsa-miR-499a-5p	CLIP-seq
MIRT1967313	hsa-miR-505	CLIP-seq
MIRT2202968	hsa-miR-513a-3p	CLIP-seq
MIRT1967314	hsa-miR-516b	CLIP-seq
MIRT901139	hsa-miR-548c-3p	CLIP-seq
MIRT2505804	hsa-miR-549	CLIP-seq
MIRT901140	hsa-miR-550b	CLIP-seq
MIRT1967315	hsa-miR-607	CLIP-seq
MIRT2505805	hsa-miR-665	CLIP-seq
MIRT1967318	hsa-miR-676	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IDA	15769875
GO:0000288	Process	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IBA
GO:0000289	Process	Nuclear-transcribed mRNA poly(A) tail shortening	NAS	31320642
GO:0000932	Component	P-body	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004535	Function	Poly(A)-specific ribonuclease activity	IBA
GO:0004535	Function	Poly(A)-specific ribonuclease activity	IDA	15769875
GO:0004535	Function	Poly(A)-specific ribonuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	10637334, 11136725, 11747467, 16189514, 16778766, 17452450, 20211142, 20584987, 20595389, 21900206, 22977175, 25416956, 26496610, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	9820826
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006417	Process	Regulation of translation	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	19605561
GO:0016787	Function	Hydrolase activity	IEA
GO:0030014	Component	CCR4-NOT complex	IDA	19558367
GO:0030014	Component	CCR4-NOT complex	IEA
GO:0030014	Component	CCR4-NOT complex	NAS	19558367
GO:0030015	Component	CCR4-NOT core complex	IBA
GO:0031047	Process	Regulatory ncRNA-mediated gene silencing	IEA
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IDA	20065043
GO:0035279	Process	MiRNA-mediated gene silencing by mRNA destabilization	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061014	Process	Positive regulation of mRNA catabolic process	IMP	22977175

Other IDs

• MIM: 603731
• HGNC: 9207
• e!Ensembl: ENSG00000155508

Protein

• UniProt ID: Q9UFF9
• Protein name: CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b)
• Protein function: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04857	CAF1	15 → 139	CAF1 family ribonuclease	Family
  PF04857	CAF1	142 → 238	CAF1 family ribonuclease	Family

• Sequence:

  MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFPGVVVRPIGEFRSSIDY
  QYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFNLTEDMYSQDSIDLLANSG
  LQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGYDFGYMVKLLTDSRLPEEEHE
  FFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDLQRIGRQHQAGSDSLLTGMAFFR
  MKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDSAQEKMSILAIINNMQQ

• Sequence length: 292

Pathways

KEGG Pathway	Reactome Pathway
RNA degradation	Deadenylation of mRNA
	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CNOT1 3 shared pathwaysRNA degradation, Deadenylation of mRNA, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Related via 3 shared pathways including RNA degradation, Deadenylation of mRNA. CNOT6L 3 shared pathwaysRNA degradation, Deadenylation of mRNA, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Related via 3 shared pathways including RNA degradation, Deadenylation of mRNA. CNOT10 3 shared pathwaysRNA degradation, Deadenylation of mRNA, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Related via 3 shared pathways including RNA degradation, Deadenylation of mRNA. CNOT7 3 shared pathwaysRNA degradation, Deadenylation of mRNA, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Related via 3 shared pathways including RNA degradation, Deadenylation of mRNA. CNOT2 3 shared pathwaysRNA degradation, Deadenylation of mRNA, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Related via 3 shared pathways including RNA degradation, Deadenylation of mRNA.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CNOT1	0	[]	3	["RNA degradation","Deadenylation of mRNA","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"]	0	[]
CNOT6L	0	[]	3	["RNA degradation","Deadenylation of mRNA","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"]	0	[]
CNOT10	0	[]	3	["RNA degradation","Deadenylation of mRNA","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"]	0	[]
CNOT7	0	[]	3	["RNA degradation","Deadenylation of mRNA","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"]	0	[]
CNOT2	0	[]	3	["RNA degradation","Deadenylation of mRNA","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"]	0	[]

Diseases Linked via Similar Genes

Neurodevelopmental disorder Linked via 2 of 5 related genesCNOT1, CNOT2 Schizophrenia Linked via 2 of 5 related genesCNOT1, CNOT7 Autism Linked via 1 of 5 related genesCNOT1 Holoprosencephaly Linked via 1 of 5 related genesCNOT1 Intellectual developmental disorder Linked via 1 of 5 related genesCNOT1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Neurodevelopmental disorder	2	["CNOT1","CNOT2"]
Schizophrenia	2	["CNOT1","CNOT7"]
Autism	1	["CNOT1"]
Holoprosencephaly	1	["CNOT1"]
Intellectual developmental disorder	1	["CNOT1"]