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Gene Gene information from NCBI Gene database.
Entrez ID 246175
Gene name CCR4-NOT transcription complex subunit 6 like
Gene symbol CNOT6L
Synonyms (NCBI Gene)
CCR4b
Chromosome 4
Chromosome location 4q21.1
miRNA miRNA information provided by mirtarbase database.
1077 Show/Hide all (1077)
miRTarBase ID miRNA Experiments Reference
MIRT045252 hsa-miR-186-5p CLASH 23622248
MIRT044340 hsa-miR-106b-5p CLASH 23622248
MIRT437923 hsa-miR-146a-5p Luciferase reporter assay 23591815
MIRT437923 hsa-miR-146a-5p Luciferase reporter assay 23591815
MIRT624313 hsa-miR-4687-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31 Show/Hide all (31)
GO ID Ontology Definition Evidence Reference
GO:0000175 Function 3'-5'-RNA exonuclease activity IBA
GO:0000288 Process Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening IEA
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening NAS 31320642
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618069 18042 ENSG00000138767
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96LI5
Protein name CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B)
Protein function Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degr
PDB 3NGN , 3NGO , 3NGQ , 5DV2 , 5DV4 , 7VOI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03372 Exo_endo_phos 192 → 529 Endonuclease/Exonuclease/phosphatase family Domain
PF13855 LRR_8 56 → 114 Leucine rich repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. {ECO:0000269|PubMed:17452450}.
Sequence
Sequence length 555
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
RNA degradation Deadenylation of mRNA
  TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain