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Gene Gene information from NCBI Gene database.
Entrez ID 904
Gene name Cyclin T1
Gene symbol CCNT1
Synonyms (NCBI Gene)
CCNTCYCT1HIVE1
Chromosome 12
Chromosome location 12q13.11-q13.12
Summary This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple form
miRNA miRNA information provided by mirtarbase database.
324 Show/Hide all (324)
miRTarBase ID miRNA Experiments Reference
MIRT004603 hsa-miR-198 Luciferase reporter assay 19148268
MIRT004603 hsa-miR-198 Luciferase reporter assay 19148268
MIRT004603 hsa-miR-198 Luciferase reporter assay 19148268
MIRT004603 hsa-miR-198 Luciferase reporter assay 19148268
MIRT004603 hsa-miR-198 Luciferase reporter assay 19148268
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
PML Unknown 12727882
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42 Show/Hide all (42)
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9499409
GO:0000976 Function Transcription cis-regulatory region binding IEA
GO:0003677 Function DNA binding IDA 16109376
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 9499409, 12832472, 12944466, 15107825, 15563843, 17289077, 17690245, 17724342, 18281698, 18483487, 18566585, 19387490, 19883659, 19914168, 20153263, 20535204, 20562857, 21220424, 21533037, 21729782, 22190034, 22959624, 23455922, 23602568, 24360279, 24981860, 26659056, 28514442, 3013
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
143055 1599 ENSG00000129315
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60563
Protein name Cyclin-T1 (CycT1) (Cyclin-T)
Protein function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD
PDB 2PK2 , 3BLH , 3BLQ , 3BLR , 3LQ5 , 3MI9 , 3MIA , 3MY1 , 3TN8 , 3TNH , 3TNI , 4BCF , 4BCG , 4BCH , 4BCI , 4BCJ , 4EC8 , 4EC9 , 4IMY , 4OGR , 4OR5 , 5L1Z , 6CYT , 6GZH , 6W9E , 6Z45 , 7NWK , 8I0L , 8K5R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00134 Cyclin_N 10 → 149 Cyclin, N-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:9491887, ECO:0000269|PubMed:9499409}.
Sequence
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTIN
TAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPD
TRSEAYLQQVQDLVILESIILQTLGFELT
IDHPHTHVVKCTQLVRASKDLAQTSYFMATN
SLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHE
FLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLM
SMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGV
DHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAY
AAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEI
KMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNK
RPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSL
NFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDT
VNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPP
LPPLPK
Sequence length 726
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex
Transcriptional misregulation in cancer Formation of HIV-1 elongation complex containing HIV-1 Tat
  Interactions of Tat with host cellular proteins
  SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  RNA Polymerase II Pre-transcription Events
  TP53 Regulates Transcription of DNA Repair Genes
  RNA polymerase II transcribes snRNA genes
  RNA Polymerase II Transcription Elongation
  Estrogen-dependent gene expression