Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6827
Gene name	SPT4 homolog, DSIF elongation factor subunit
Gene symbol	SUPT4H1
Synonyms (NCBI Gene)	SPT4SPT4HSUPT4HSupt4a
Chromosome	17
Chromosome location	17q22
Summary	This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025924	hsa-miR-7-5p	Microarray	19073608
MIRT027878	hsa-miR-96-5p	Sequencing	20371350
MIRT051537	hsa-let-7e-5p	CLASH	23622248
MIRT1403533	hsa-miR-1206	CLIP-seq
MIRT1403534	hsa-miR-1207-3p	CLIP-seq
MIRT1403535	hsa-miR-124	CLIP-seq
MIRT1403536	hsa-miR-1253	CLIP-seq
MIRT1403537	hsa-miR-1303	CLIP-seq
MIRT1403538	hsa-miR-132	CLIP-seq
MIRT1403539	hsa-miR-1909	CLIP-seq
MIRT1403540	hsa-miR-200b	CLIP-seq
MIRT1403541	hsa-miR-200c	CLIP-seq
MIRT1403542	hsa-miR-2110	CLIP-seq
MIRT1403543	hsa-miR-212	CLIP-seq
MIRT1403544	hsa-miR-219-2-3p	CLIP-seq
MIRT1403545	hsa-miR-23a	CLIP-seq
MIRT1403546	hsa-miR-23b	CLIP-seq
MIRT1403547	hsa-miR-23c	CLIP-seq
MIRT1403548	hsa-miR-2964a-3p	CLIP-seq
MIRT1403549	hsa-miR-3121-3p	CLIP-seq
MIRT1403550	hsa-miR-3162-5p	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT1403552	hsa-miR-3180-5p	CLIP-seq
MIRT1403553	hsa-miR-3189-3p	CLIP-seq
MIRT1403554	hsa-miR-3616-5p	CLIP-seq
MIRT1403555	hsa-miR-3622b-5p	CLIP-seq
MIRT1403556	hsa-miR-3647-5p	CLIP-seq
MIRT1403557	hsa-miR-3661	CLIP-seq
MIRT1403558	hsa-miR-369-3p	CLIP-seq
MIRT1403559	hsa-miR-374a	CLIP-seq
MIRT1403560	hsa-miR-374b	CLIP-seq
MIRT1403561	hsa-miR-410	CLIP-seq
MIRT1403562	hsa-miR-421	CLIP-seq
MIRT1403563	hsa-miR-4271	CLIP-seq
MIRT1403564	hsa-miR-429	CLIP-seq
MIRT1403565	hsa-miR-4310	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT1403567	hsa-miR-4427	CLIP-seq
MIRT1403568	hsa-miR-4443	CLIP-seq
MIRT1403569	hsa-miR-4450	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT1403572	hsa-miR-4496	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT1403574	hsa-miR-4640-5p	CLIP-seq
MIRT1403575	hsa-miR-4642	CLIP-seq
MIRT1403576	hsa-miR-4652-3p	CLIP-seq
MIRT1403577	hsa-miR-4670-3p	CLIP-seq
MIRT1403578	hsa-miR-4680-3p	CLIP-seq
MIRT1403579	hsa-miR-4698	CLIP-seq
MIRT1403580	hsa-miR-4709-3p	CLIP-seq
MIRT1403581	hsa-miR-4709-5p	CLIP-seq
MIRT1403582	hsa-miR-4725-3p	CLIP-seq
MIRT1403583	hsa-miR-4726-5p	CLIP-seq
MIRT1403584	hsa-miR-4728-5p	CLIP-seq
MIRT1403585	hsa-miR-4729	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT1403587	hsa-miR-4775	CLIP-seq
MIRT1403588	hsa-miR-506	CLIP-seq
MIRT1403589	hsa-miR-5096	CLIP-seq
MIRT1403590	hsa-miR-520a-5p	CLIP-seq
MIRT1403591	hsa-miR-525-5p	CLIP-seq
MIRT1403592	hsa-miR-548ag	CLIP-seq
MIRT1403593	hsa-miR-548ai	CLIP-seq
MIRT1403594	hsa-miR-573	CLIP-seq
MIRT1403595	hsa-miR-579	CLIP-seq
MIRT1403596	hsa-miR-590-3p	CLIP-seq
MIRT1403597	hsa-miR-627	CLIP-seq
MIRT1403598	hsa-miR-631	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT1403600	hsa-miR-877	CLIP-seq
MIRT1403601	hsa-miR-924	CLIP-seq
MIRT1403602	hsa-miR-944	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1554322	hsa-miR-4705	CLIP-seq
MIRT1403534	hsa-miR-1207-3p	CLIP-seq
MIRT2120974	hsa-miR-1207-5p	CLIP-seq
MIRT2120975	hsa-miR-1224-3p	CLIP-seq
MIRT2120976	hsa-miR-1227	CLIP-seq
MIRT2120977	hsa-miR-1260	CLIP-seq
MIRT2120978	hsa-miR-1260b	CLIP-seq
MIRT2120979	hsa-miR-1280	CLIP-seq
MIRT1403544	hsa-miR-219-2-3p	CLIP-seq
MIRT1403548	hsa-miR-2964a-3p	CLIP-seq
MIRT2120980	hsa-miR-298	CLIP-seq
MIRT2120981	hsa-miR-300	CLIP-seq
MIRT2120982	hsa-miR-30a	CLIP-seq
MIRT2120983	hsa-miR-30b	CLIP-seq
MIRT2120984	hsa-miR-30c	CLIP-seq
MIRT2120985	hsa-miR-30d	CLIP-seq
MIRT2120986	hsa-miR-30e	CLIP-seq
MIRT2120987	hsa-miR-3163	CLIP-seq
MIRT2120988	hsa-miR-3616-3p	CLIP-seq
MIRT2120989	hsa-miR-3662	CLIP-seq
MIRT2120990	hsa-miR-381	CLIP-seq
MIRT1403567	hsa-miR-4427	CLIP-seq
MIRT2120991	hsa-miR-4436b-3p	CLIP-seq
MIRT1403568	hsa-miR-4443	CLIP-seq
MIRT2120992	hsa-miR-4514	CLIP-seq
MIRT1403578	hsa-miR-4680-3p	CLIP-seq
MIRT2120993	hsa-miR-4692	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2120994	hsa-miR-4755-3p	CLIP-seq
MIRT2120995	hsa-miR-4763-3p	CLIP-seq
MIRT2120996	hsa-miR-516a-5p	CLIP-seq
MIRT2120997	hsa-miR-532-3p	CLIP-seq
MIRT2120998	hsa-miR-577	CLIP-seq
MIRT2120999	hsa-miR-595	CLIP-seq
MIRT1403597	hsa-miR-627	CLIP-seq
MIRT1403601	hsa-miR-924	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT2342968	hsa-let-7a	CLIP-seq
MIRT2342969	hsa-let-7b	CLIP-seq
MIRT2342970	hsa-let-7c	CLIP-seq
MIRT2342971	hsa-let-7d	CLIP-seq
MIRT2342972	hsa-let-7e	CLIP-seq
MIRT2342973	hsa-let-7f	CLIP-seq
MIRT2342974	hsa-let-7g	CLIP-seq
MIRT2342975	hsa-let-7i	CLIP-seq
MIRT2342976	hsa-miR-1200	CLIP-seq
MIRT1403534	hsa-miR-1207-3p	CLIP-seq
MIRT2120974	hsa-miR-1207-5p	CLIP-seq
MIRT2120976	hsa-miR-1227	CLIP-seq
MIRT1403535	hsa-miR-124	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT1403538	hsa-miR-132	CLIP-seq
MIRT2342977	hsa-miR-192	CLIP-seq
MIRT1403540	hsa-miR-200b	CLIP-seq
MIRT1403541	hsa-miR-200c	CLIP-seq
MIRT2342978	hsa-miR-202	CLIP-seq
MIRT1403542	hsa-miR-2110	CLIP-seq
MIRT1403543	hsa-miR-212	CLIP-seq
MIRT2342979	hsa-miR-215	CLIP-seq
MIRT1403544	hsa-miR-219-2-3p	CLIP-seq
MIRT1403545	hsa-miR-23a	CLIP-seq
MIRT1403546	hsa-miR-23b	CLIP-seq
MIRT1403547	hsa-miR-23c	CLIP-seq
MIRT1403548	hsa-miR-2964a-3p	CLIP-seq
MIRT2120982	hsa-miR-30a	CLIP-seq
MIRT2120983	hsa-miR-30b	CLIP-seq
MIRT2120984	hsa-miR-30c	CLIP-seq
MIRT2120985	hsa-miR-30d	CLIP-seq
MIRT2120986	hsa-miR-30e	CLIP-seq
MIRT2342980	hsa-miR-3154	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT1403553	hsa-miR-3189-3p	CLIP-seq
MIRT2342981	hsa-miR-335	CLIP-seq
MIRT1403555	hsa-miR-3622b-5p	CLIP-seq
MIRT1403558	hsa-miR-369-3p	CLIP-seq
MIRT1403559	hsa-miR-374a	CLIP-seq
MIRT1403560	hsa-miR-374b	CLIP-seq
MIRT1403561	hsa-miR-410	CLIP-seq
MIRT1403562	hsa-miR-421	CLIP-seq
MIRT1403563	hsa-miR-4271	CLIP-seq
MIRT1403564	hsa-miR-429	CLIP-seq
MIRT2342982	hsa-miR-4324	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT1403567	hsa-miR-4427	CLIP-seq
MIRT1403568	hsa-miR-4443	CLIP-seq
MIRT2342983	hsa-miR-4458	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT2342984	hsa-miR-4500	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT2120992	hsa-miR-4514	CLIP-seq
MIRT1403575	hsa-miR-4642	CLIP-seq
MIRT2342985	hsa-miR-4659a-3p	CLIP-seq
MIRT2342986	hsa-miR-4659b-3p	CLIP-seq
MIRT1403578	hsa-miR-4680-3p	CLIP-seq
MIRT2120993	hsa-miR-4692	CLIP-seq
MIRT1554322	hsa-miR-4705	CLIP-seq
MIRT1403581	hsa-miR-4709-5p	CLIP-seq
MIRT1403582	hsa-miR-4725-3p	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2342987	hsa-miR-4753-3p	CLIP-seq
MIRT2120994	hsa-miR-4755-3p	CLIP-seq
MIRT2120995	hsa-miR-4763-3p	CLIP-seq
MIRT1403587	hsa-miR-4775	CLIP-seq
MIRT2342988	hsa-miR-489	CLIP-seq
MIRT1403588	hsa-miR-506	CLIP-seq
MIRT1403589	hsa-miR-5096	CLIP-seq
MIRT2342989	hsa-miR-544b	CLIP-seq
MIRT2342990	hsa-miR-548l	CLIP-seq
MIRT2342991	hsa-miR-548n	CLIP-seq
MIRT1403596	hsa-miR-590-3p	CLIP-seq
MIRT1403597	hsa-miR-627	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT1403601	hsa-miR-924	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT2342992	hsa-miR-98	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT1403545	hsa-miR-23a	CLIP-seq
MIRT1403546	hsa-miR-23b	CLIP-seq
MIRT1403547	hsa-miR-23c	CLIP-seq
MIRT1554322	hsa-miR-4705	CLIP-seq
MIRT1403589	hsa-miR-5096	CLIP-seq
MIRT1403536	hsa-miR-1253	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT2636901	hsa-miR-1321	CLIP-seq
MIRT2636902	hsa-miR-1470	CLIP-seq
MIRT1403539	hsa-miR-1909	CLIP-seq
MIRT2636903	hsa-miR-193a-3p	CLIP-seq
MIRT2636904	hsa-miR-193b	CLIP-seq
MIRT2636905	hsa-miR-2116	CLIP-seq
MIRT2636906	hsa-miR-3065-3p	CLIP-seq
MIRT1403549	hsa-miR-3121-3p	CLIP-seq
MIRT2636907	hsa-miR-3123	CLIP-seq
MIRT2342980	hsa-miR-3154	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT2636908	hsa-miR-3170	CLIP-seq
MIRT2636909	hsa-miR-3176	CLIP-seq
MIRT2636910	hsa-miR-3192	CLIP-seq
MIRT2636911	hsa-miR-3194-3p	CLIP-seq
MIRT2636912	hsa-miR-326	CLIP-seq
MIRT2636913	hsa-miR-330-5p	CLIP-seq
MIRT2342981	hsa-miR-335	CLIP-seq
MIRT2636914	hsa-miR-3612	CLIP-seq
MIRT2636915	hsa-miR-3664-3p	CLIP-seq
MIRT2636916	hsa-miR-3665	CLIP-seq
MIRT2636917	hsa-miR-3672	CLIP-seq
MIRT2636918	hsa-miR-3714	CLIP-seq
MIRT2636919	hsa-miR-3918	CLIP-seq
MIRT2636920	hsa-miR-3922-3p	CLIP-seq
MIRT2636921	hsa-miR-3929	CLIP-seq
MIRT2636922	hsa-miR-3934	CLIP-seq
MIRT2636923	hsa-miR-4314	CLIP-seq
MIRT2636924	hsa-miR-4318	CLIP-seq
MIRT2636925	hsa-miR-4329	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT2636926	hsa-miR-4419b	CLIP-seq
MIRT2120991	hsa-miR-4436b-3p	CLIP-seq
MIRT2636927	hsa-miR-4463	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT2636928	hsa-miR-4478	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT2636929	hsa-miR-4512	CLIP-seq
MIRT2636930	hsa-miR-4646-5p	CLIP-seq
MIRT2342985	hsa-miR-4659a-3p	CLIP-seq
MIRT2342986	hsa-miR-4659b-3p	CLIP-seq
MIRT2636931	hsa-miR-4685-5p	CLIP-seq
MIRT2636932	hsa-miR-4693-5p	CLIP-seq
MIRT2636933	hsa-miR-4708-3p	CLIP-seq
MIRT1403580	hsa-miR-4709-3p	CLIP-seq
MIRT1403584	hsa-miR-4728-5p	CLIP-seq
MIRT2636934	hsa-miR-4733-3p	CLIP-seq
MIRT2636935	hsa-miR-4736	CLIP-seq
MIRT2636936	hsa-miR-4739	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2636937	hsa-miR-4756-5p	CLIP-seq
MIRT2636938	hsa-miR-4757-5p	CLIP-seq
MIRT2636939	hsa-miR-4761-3p	CLIP-seq
MIRT2636940	hsa-miR-4782-5p	CLIP-seq
MIRT2636941	hsa-miR-485-5p	CLIP-seq
MIRT2120996	hsa-miR-516a-5p	CLIP-seq
MIRT2636942	hsa-miR-520d-5p	CLIP-seq
MIRT2636943	hsa-miR-524-5p	CLIP-seq
MIRT1403592	hsa-miR-548ag	CLIP-seq
MIRT1403593	hsa-miR-548ai	CLIP-seq
MIRT2636944	hsa-miR-550a	CLIP-seq
MIRT2636945	hsa-miR-650	CLIP-seq
MIRT2636946	hsa-miR-7	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT2636947	hsa-miR-892a	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT1403602	hsa-miR-944	CLIP-seq
MIRT1403536	hsa-miR-1253	CLIP-seq
MIRT1554321	hsa-miR-1283	CLIP-seq
MIRT2636901	hsa-miR-1321	CLIP-seq
MIRT2636902	hsa-miR-1470	CLIP-seq
MIRT1403539	hsa-miR-1909	CLIP-seq
MIRT2636903	hsa-miR-193a-3p	CLIP-seq
MIRT2636904	hsa-miR-193b	CLIP-seq
MIRT2636905	hsa-miR-2116	CLIP-seq
MIRT2636906	hsa-miR-3065-3p	CLIP-seq
MIRT1403549	hsa-miR-3121-3p	CLIP-seq
MIRT2636907	hsa-miR-3123	CLIP-seq
MIRT2342980	hsa-miR-3154	CLIP-seq
MIRT1403551	hsa-miR-3167	CLIP-seq
MIRT2636908	hsa-miR-3170	CLIP-seq
MIRT2636909	hsa-miR-3176	CLIP-seq
MIRT2636910	hsa-miR-3192	CLIP-seq
MIRT2636911	hsa-miR-3194-3p	CLIP-seq
MIRT2636912	hsa-miR-326	CLIP-seq
MIRT2636913	hsa-miR-330-5p	CLIP-seq
MIRT2342981	hsa-miR-335	CLIP-seq
MIRT2636914	hsa-miR-3612	CLIP-seq
MIRT2636915	hsa-miR-3664-3p	CLIP-seq
MIRT2636916	hsa-miR-3665	CLIP-seq
MIRT2636917	hsa-miR-3672	CLIP-seq
MIRT2636918	hsa-miR-3714	CLIP-seq
MIRT2636919	hsa-miR-3918	CLIP-seq
MIRT2636920	hsa-miR-3922-3p	CLIP-seq
MIRT2636921	hsa-miR-3929	CLIP-seq
MIRT2636922	hsa-miR-3934	CLIP-seq
MIRT2636923	hsa-miR-4314	CLIP-seq
MIRT2636924	hsa-miR-4318	CLIP-seq
MIRT2636925	hsa-miR-4329	CLIP-seq
MIRT1403566	hsa-miR-4419a	CLIP-seq
MIRT2636926	hsa-miR-4419b	CLIP-seq
MIRT2120991	hsa-miR-4436b-3p	CLIP-seq
MIRT2636927	hsa-miR-4463	CLIP-seq
MIRT1403570	hsa-miR-4476	CLIP-seq
MIRT1403571	hsa-miR-4477a	CLIP-seq
MIRT2636928	hsa-miR-4478	CLIP-seq
MIRT1403573	hsa-miR-4510	CLIP-seq
MIRT2636929	hsa-miR-4512	CLIP-seq
MIRT2636930	hsa-miR-4646-5p	CLIP-seq
MIRT2342985	hsa-miR-4659a-3p	CLIP-seq
MIRT2342986	hsa-miR-4659b-3p	CLIP-seq
MIRT2636931	hsa-miR-4685-5p	CLIP-seq
MIRT2636932	hsa-miR-4693-5p	CLIP-seq
MIRT2636933	hsa-miR-4708-3p	CLIP-seq
MIRT1403580	hsa-miR-4709-3p	CLIP-seq
MIRT1403584	hsa-miR-4728-5p	CLIP-seq
MIRT2636934	hsa-miR-4733-3p	CLIP-seq
MIRT2636935	hsa-miR-4736	CLIP-seq
MIRT2636936	hsa-miR-4739	CLIP-seq
MIRT1403586	hsa-miR-4747-5p	CLIP-seq
MIRT2636937	hsa-miR-4756-5p	CLIP-seq
MIRT2636938	hsa-miR-4757-5p	CLIP-seq
MIRT2636939	hsa-miR-4761-3p	CLIP-seq
MIRT2636940	hsa-miR-4782-5p	CLIP-seq
MIRT2636941	hsa-miR-485-5p	CLIP-seq
MIRT2120996	hsa-miR-516a-5p	CLIP-seq
MIRT2636942	hsa-miR-520d-5p	CLIP-seq
MIRT2636943	hsa-miR-524-5p	CLIP-seq
MIRT1403592	hsa-miR-548ag	CLIP-seq
MIRT1403593	hsa-miR-548ai	CLIP-seq
MIRT2636944	hsa-miR-550a	CLIP-seq
MIRT2636945	hsa-miR-650	CLIP-seq
MIRT2636946	hsa-miR-7	CLIP-seq
MIRT1403599	hsa-miR-876-5p	CLIP-seq
MIRT2636947	hsa-miR-892a	CLIP-seq
MIRT2121000	hsa-miR-940	CLIP-seq
MIRT1403602	hsa-miR-944	CLIP-seq

25 Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	9450929, 9857195
GO:0000993	Function	RNA polymerase II complex binding	IBA
GO:0005515	Function	Protein binding	IPI	10075709, 17404243, 24981860, 25416956, 25502805, 26496610, 26789250, 27107012, 31515488, 35271311
GO:0005634	Component	Nucleus	IDA	9450929
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	TAS	8786137
GO:0006368	Process	Transcription elongation by RNA polymerase II	IBA
GO:0006368	Process	Transcription elongation by RNA polymerase II	IDA	9450929, 9857195
GO:0008270	Function	Zinc ion binding	IEA
GO:0032044	Component	DSIF complex	IBA
GO:0032044	Component	DSIF complex	IDA	9450929
GO:0032044	Component	DSIF complex	IPI	19860741
GO:0032785	Process	Negative regulation of DNA-templated transcription, elongation	IDA	9450929, 9857195
GO:0032785	Process	Negative regulation of DNA-templated transcription, elongation	IEA
GO:0032786	Process	Positive regulation of DNA-templated transcription, elongation	IDA	9450929
GO:0034243	Process	Regulation of transcription elongation by RNA polymerase II	IDA	9450929
GO:0034243	Process	Regulation of transcription elongation by RNA polymerase II	IEA
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9450929
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	9450929
GO:0140673	Process	Transcription elongation-coupled chromatin remodeling	IEA

MIM	HGNC	e!Ensembl
603555	11467	ENSG00000213246

P63272

Protein name

Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)

Protein function

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed:10075709, PubMed:10199401, PubMed:10454543, PubMed:10912001, PubMed:11112772, PubM

PDB

3H7H , 5OIK , 6GMH , 6GML , 6TED , 7OKY , 7UND , 7YCX , 8A3Y , 8P4C , 8P4D , 8P4F , 8UHA , 8UHD , 8W8E , 8W8F , 9EGX , 9EGY , 9EGZ , 9EH0 , 9EH1 , 9EH2 , 9J0N , 9J0O , 9J0P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06093	Spt4	13 → 90	Spt4/RpoE2 zinc finger	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:8649394, ECO:0000269|PubMed:8786137}.

Sequence

MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGI
IAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT

Sequence length

117

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Viral life cycle - HIV-1	Formation of RNA Pol II elongation complex
	Formation of the Early Elongation Complex
	Formation of HIV-1 elongation complex containing HIV-1 Tat
	RNA Polymerase II Pre-transcription Events
	TP53 Regulates Transcription of DNA Repair Genes
	RNA polymerase II transcribes snRNA genes
	RNA Polymerase II Transcription Elongation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	31969693	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	33398198	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	33398198	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	31488892	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (11)
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	30605685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	30605685	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	32444848	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27461012		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	27461012	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	25760041		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	28009271, 30605685	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	30605685		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	31917448	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Peritonitis	Peritonitis	Pubtator	27461012	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spinocerebellar ataxia 36	Spinocerebellar Ataxia	BEFREE	30610877		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NELFB	[]	7	["Viral life cycle - HIV-1","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of the Early Elongation Complex","Formation of HIV-1 elongation complex containing HIV-1 Tat"]	[]
NELFCD	[]	7	["Viral life cycle - HIV-1","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of the Early Elongation Complex","Formation of HIV-1 elongation complex containing HIV-1 Tat"]	[]
NELFA	[]	7	["Viral life cycle - HIV-1","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of the Early Elongation Complex","Formation of HIV-1 elongation complex containing HIV-1 Tat"]	[]
NELFE	[]	7	["Viral life cycle - HIV-1","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of the Early Elongation Complex","Formation of HIV-1 elongation complex containing HIV-1 Tat"]	[]
SUPT5H	[]	8	["Viral life cycle - HIV-1","Formation of RNA Pol II elongation complex ","RNA Polymerase II Pre-transcription Events","TP53 Regulates Transcription of DNA Repair Genes","RNA Polymerase II Transcription Elongation","Formation of the Early Elongation Complex","RNA polymerase II transcribes snRNA genes","Formation of HIV-1 elongation complex containing HIV-1 Tat"]	[]

SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

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