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Gene Gene information from NCBI Gene database.
Entrez ID 905
Gene name Cyclin T2
Gene symbol CCNT2
Synonyms (NCBI Gene)
CYCT2
Chromosome 2
Chromosome location 2q21.3
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit
miRNA miRNA information provided by mirtarbase database.
959 Show/Hide all (959)
miRTarBase ID miRNA Experiments Reference
MIRT001801 hsa-miR-16-5p Luciferase reporter assay 15131085
MIRT020397 hsa-miR-29c-3p Sequencing 20371350
MIRT026073 hsa-miR-196a-5p Sequencing 20371350
MIRT030643 hsa-miR-22-3p Sequencing 20371350
MIRT001801 hsa-miR-16-5p Reporter assay;Other 15131085
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36 Show/Hide all (36)
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9499409
GO:0001223 Function Transcription coactivator binding IPI 12037672
GO:0003682 Function Chromatin binding IEA
GO:0003682 Function Chromatin binding ISS
GO:0005515 Function Protein binding IPI 9499409, 15563843, 17289077, 19883659, 21509660, 21729782, 23455922, 23602568, 24981860, 32707033, 33961781, 35271311
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603862 1600 ENSG00000082258
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60583
Protein name Cyclin-T2 (CycT2)
Protein function Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphoryla
PDB 2IVX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00134 Cyclin_N 9 → 148 Cyclin, N-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:9499409}.
Sequence
MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINT
AIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDT
KCDAYLQQTQELVILETIMLQTLGFEIT
IEHPHTDVVKCTQLVRASKDLAQTSYFMATNS
LHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEF
LQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPS
FQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSART
EQLYSQKQETSLSGSQYNINFQQGPSISLHSGLHHRPDKISDHSSVKQEYTHKAGSSKHH
GPISTTPGIIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKQGQSQAASSSSVTS
PIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDE
GSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLR
SPVGLSSDGISSSSSSSRKRLHVNDASHNHHSKMSKSSKSSGSSSSSSSSVKQYISSHNS
VFNHPLPPPPPVTYQVGYGHLSTLVKLDKKPVETNGPDANHEYSTSSQHMDYKDTFDMLD
SLLSAQGMNM
Sequence length 730
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex
Transcriptional misregulation in cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  RNA Polymerase II Pre-transcription Events
  TP53 Regulates Transcription of DNA Repair Genes
  RNA polymerase II transcribes snRNA genes
  RNA Polymerase II Transcription Elongation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Premature ovarian insufficiency Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (7)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 33574088 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Celiac Disease Celiac disease Pubtator 27650971 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Centronuclear myopathy Centronuclear Myopathy BEFREE 11373316
★★★★★
★☆☆☆☆
Found in Text Mining only
Chronic Kidney Diseases Kidney Disease BEFREE 30209133
★★★★★
★☆☆☆☆
Found in Text Mining only
Leukemia, Myelocytic, Acute Leukemia BEFREE 28409330
★★★★★
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 29849811
★★★★★
★☆☆☆☆
Found in Text Mining only
Osteosarcoma Osteosarcoma Pubtator 31957815 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only