Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	160
Gene name	Adaptor related protein complex 2 subunit alpha 1
Gene symbol	AP2A1
Synonyms (NCBI Gene)	ADTAAAP2-ALPHACLAPA1
Chromosome	19
Chromosome location	19q13.33
Summary	This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sig

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005209	hsa-miR-30a-5p	pSILAC	18668040
MIRT023447	hsa-miR-30b-5p	Sequencing	20371350
MIRT025297	hsa-miR-34a-5p	Proteomics	21566225
MIRT025297	hsa-miR-34a-5p	Proteomics	21566225
MIRT025297	hsa-miR-34a-5p	Proteomics	21566225
MIRT027091	hsa-miR-103a-3p	Sequencing	20371350
MIRT005209	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT031661	hsa-miR-16-5p	Sequencing	20371350
MIRT031661	hsa-miR-16-5p	Proteomics	18668040
MIRT046880	hsa-miR-221-3p	CLASH	23622248
MIRT042848	hsa-miR-324-3p	CLASH	23622248
MIRT787537	hsa-miR-1245b-3p	CLIP-seq
MIRT787538	hsa-miR-15a	CLIP-seq
MIRT787539	hsa-miR-15b	CLIP-seq
MIRT787540	hsa-miR-16	CLIP-seq
MIRT787541	hsa-miR-195	CLIP-seq
MIRT787542	hsa-miR-30a	CLIP-seq
MIRT787543	hsa-miR-30b	CLIP-seq
MIRT787544	hsa-miR-30c	CLIP-seq
MIRT787545	hsa-miR-30d	CLIP-seq
MIRT787546	hsa-miR-30e	CLIP-seq
MIRT787547	hsa-miR-361-3p	CLIP-seq
MIRT787548	hsa-miR-424	CLIP-seq
MIRT787549	hsa-miR-4495	CLIP-seq
MIRT787550	hsa-miR-497	CLIP-seq
MIRT787551	hsa-miR-922	CLIP-seq
MIRT787552	hsa-miR-1193	CLIP-seq
MIRT787553	hsa-miR-3150a-3p	CLIP-seq
MIRT787554	hsa-miR-3175	CLIP-seq
MIRT787555	hsa-miR-331-3p	CLIP-seq
MIRT787547	hsa-miR-361-3p	CLIP-seq
MIRT787556	hsa-miR-369-3p	CLIP-seq
MIRT787557	hsa-miR-374c	CLIP-seq
MIRT787558	hsa-miR-4308	CLIP-seq
MIRT787559	hsa-miR-4672	CLIP-seq
MIRT787560	hsa-miR-4711-3p	CLIP-seq
MIRT787561	hsa-miR-4728-5p	CLIP-seq
MIRT787562	hsa-miR-655	CLIP-seq
MIRT787563	hsa-miR-939	CLIP-seq
MIRT787564	hsa-miR-942	CLIP-seq
MIRT787537	hsa-miR-1245b-3p	CLIP-seq
MIRT787538	hsa-miR-15a	CLIP-seq
MIRT787539	hsa-miR-15b	CLIP-seq
MIRT787540	hsa-miR-16	CLIP-seq
MIRT787541	hsa-miR-195	CLIP-seq
MIRT787542	hsa-miR-30a	CLIP-seq
MIRT787543	hsa-miR-30b	CLIP-seq
MIRT787544	hsa-miR-30c	CLIP-seq
MIRT787545	hsa-miR-30d	CLIP-seq
MIRT787546	hsa-miR-30e	CLIP-seq
MIRT787548	hsa-miR-424	CLIP-seq
MIRT787549	hsa-miR-4495	CLIP-seq
MIRT787550	hsa-miR-497	CLIP-seq
MIRT787551	hsa-miR-922	CLIP-seq
MIRT787561	hsa-miR-4728-5p	CLIP-seq
MIRT787564	hsa-miR-942	CLIP-seq
MIRT787561	hsa-miR-4728-5p	CLIP-seq
MIRT2435402	hsa-miR-1226	CLIP-seq
MIRT2435403	hsa-miR-1323	CLIP-seq
MIRT2435404	hsa-miR-1910	CLIP-seq
MIRT787547	hsa-miR-361-3p	CLIP-seq
MIRT2435405	hsa-miR-3689d	CLIP-seq
MIRT2435406	hsa-miR-4264	CLIP-seq
MIRT2435407	hsa-miR-455-3p	CLIP-seq
MIRT2435408	hsa-miR-4733-3p	CLIP-seq
MIRT2435409	hsa-miR-548a-3p	CLIP-seq
MIRT2435410	hsa-miR-548e	CLIP-seq
MIRT2435411	hsa-miR-548f	CLIP-seq
MIRT2435412	hsa-miR-548o	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16262731, 19116314, 22262466, 23676497
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006886	Process	Intracellular protein transport	NAS	12036598
GO:0006895	Process	Golgi to endosome transport	NAS	12036598
GO:0006897	Process	Endocytosis	IEA
GO:0006897	Process	Endocytosis	NAS	12036598
GO:0008021	Component	Synaptic vesicle	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	NAS	29184887
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016192	Process	Vesicle-mediated transport	NAS	15941406
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	ISS
GO:0030117	Component	Membrane coat	IEA
GO:0030122	Component	AP-2 adaptor complex	IBA
GO:0030122	Component	AP-2 adaptor complex	IDA	23676497
GO:0030122	Component	AP-2 adaptor complex	IEA
GO:0030122	Component	AP-2 adaptor complex	NAS	12036598, 12086608
GO:0030122	Component	AP-2 adaptor complex	TAS	12121421
GO:0030130	Component	Clathrin coat of trans-Golgi network vesicle	NAS	12036598
GO:0030131	Component	Clathrin adaptor complex	IEA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0032433	Component	Filopodium tip	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0035615	Function	Clathrin adaptor activity	IBA
GO:0035615	Function	Clathrin adaptor activity	IEA
GO:0035615	Function	Clathrin adaptor activity	TAS	12121421
GO:0036020	Component	Endolysosome membrane	IEA
GO:0036020	Component	Endolysosome membrane	TAS
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045334	Component	Clathrin-coated endocytic vesicle	NAS	25898166
GO:0048260	Process	Positive regulation of receptor-mediated endocytosis	IEA
GO:0048488	Process	Synaptic vesicle endocytosis	IEA
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IPI	26005850
GO:0072583	Process	Clathrin-dependent endocytosis	IBA
GO:0072583	Process	Clathrin-dependent endocytosis	IDA	23676497
GO:0072583	Process	Clathrin-dependent endocytosis	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	IMP	22262466
GO:0072583	Process	Clathrin-dependent endocytosis	NAS	29184887
GO:0072583	Process	Clathrin-dependent endocytosis	TAS	12121421
GO:0098843	Component	Postsynaptic endocytic zone	IEA
GO:0098884	Process	Postsynaptic neurotransmitter receptor internalization	NAS	31671891
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1900126	Process	Negative regulation of hyaluronan biosynthetic process	IDA	24251095
GO:1900126	Process	Negative regulation of hyaluronan biosynthetic process	IMP	23509262

MIM	HGNC	e!Ensembl
601026	561	ENSG00000196961

O95782

Protein name

AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain)

Protein function

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be invo

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01602	Adaptin_N	29 → 591	Adaptin N terminal region	Family
PF02296	Alpha_adaptin_C	864 → 972	Alpha adaptin AP2, C-terminal domain	Family
PF02883	Alpha_adaptinC2	751 → 858	Adaptin C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brain (at protein level) (PubMed:23676497). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer

Sequence

MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVC
KLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDL
ASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASP
DLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSA
STDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKV
QHSNAKNAILFETISLIIHYDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSE
FSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAI
REEIVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAA
KTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRAL
LLSTYIKFINLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLE
EMPPFPERESSILAKLKRKKGPGAGSALDDGRRDPSSNDINGGMEPTPSTVSTPSPSADL
LGLRAAPPPAAPPASAGAGNLLVDVFDGPAAQPSLGPTPEEAFLSELEPPAPESPMALLA
DPAPAADPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQNLGRMYLFY
GNKTSVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQVDGGAQVQQVLNIECLRDFLTPPLL
SVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMD
AEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRT
SKEPVSRHLCELLAQQF

Sequence length

977

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	Nef Mediated CD4 Down-regulation
Synaptic vesicle cycle	Retrograde neurotrophin signalling
Endocrine and other factor-regulated calcium reabsorption	Nef Mediated CD8 Down-regulation
Huntington disease	MHC class II antigen presentation
	EPH-ephrin mediated repulsion of cells
	Trafficking of GluR2-containing AMPA receptors
	Recycling pathway of L1
	WNT5A-dependent internalization of FZD4
	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
	Cargo recognition for clathrin-mediated endocytosis
	Clathrin-mediated endocytosis
	VLDLR internalisation and degradation
	LDL clearance

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
AP2S1	[]	16	["Endocytosis","Synaptic vesicle cycle","Endocrine and other factor-regulated calcium reabsorption","MHC class II antigen presentation","VLDLR internalisation and degradation","Clathrin-mediated endocytosis","Retrograde neurotrophin signalling","Cargo recognition for clathrin-mediated endocytosis","Recycling pathway of L1","EPH-ephrin mediated repulsion of cells","LDL clearance","Nef Mediated CD4 Down-regulation"]	[]
AP2A2	[]	16	["Endocytosis","Synaptic vesicle cycle","Endocrine and other factor-regulated calcium reabsorption","MHC class II antigen presentation","VLDLR internalisation and degradation","Clathrin-mediated endocytosis","Retrograde neurotrophin signalling","Cargo recognition for clathrin-mediated endocytosis","Recycling pathway of L1","EPH-ephrin mediated repulsion of cells","LDL clearance","Nef Mediated CD4 Down-regulation"]	[]
AP2B1	[]	16	["Endocytosis","Synaptic vesicle cycle","Endocrine and other factor-regulated calcium reabsorption","MHC class II antigen presentation","VLDLR internalisation and degradation","Clathrin-mediated endocytosis","Retrograde neurotrophin signalling","Cargo recognition for clathrin-mediated endocytosis","Recycling pathway of L1","EPH-ephrin mediated repulsion of cells","LDL clearance","Nef Mediated CD4 Down-regulation"]	[]
AP2M1	[]	16	["Endocytosis","Synaptic vesicle cycle","Endocrine and other factor-regulated calcium reabsorption","MHC class II antigen presentation","VLDLR internalisation and degradation","Clathrin-mediated endocytosis","Retrograde neurotrophin signalling","Cargo recognition for clathrin-mediated endocytosis","Recycling pathway of L1","EPH-ephrin mediated repulsion of cells","LDL clearance","Nef Mediated CD4 Down-regulation"]	[]
CLTA	[]	13	["Endocytosis","Synaptic vesicle cycle","Endocrine and other factor-regulated calcium reabsorption","MHC class II antigen presentation","VLDLR internalisation and degradation","Clathrin-mediated endocytosis","Retrograde neurotrophin signalling","Cargo recognition for clathrin-mediated endocytosis","Recycling pathway of L1","EPH-ephrin mediated repulsion of cells","LDL clearance","WNT5A-dependent internalization of FZD4"]	[]

AP2A1 (adaptor related protein complex 2 subunit alpha 1)

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