ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 127
• Gene name: Alcohol dehydrogenase 4 (class II), pi polypeptide
• Gene symbol: ADH4
• Synonyms (NCBI Gene): ADH-2, HEL-S-4
• Chromosome: 4
• Chromosome location: 4q23
• Summary: This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxystero

miRNA Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT768628	hsa-miR-3907	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167643	hsa-miR-1236	CLIP-seq
MIRT2167644	hsa-miR-1298	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT2167646	hsa-miR-338-3p	CLIP-seq
MIRT2167647	hsa-miR-3675-3p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167648	hsa-miR-4286	CLIP-seq
MIRT2167649	hsa-miR-4786-3p	CLIP-seq
MIRT2167650	hsa-miR-885-5p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820
GO:0003960	Function	Quinone reductase (NADPH) activity	IEA
GO:0003960	Function	Quinone reductase (NADPH) activity	ISS
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IBA
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IDA	3466164, 10407146, 16787387
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IEA
GO:0004032	Function	Aldose reductase (NADPH) activity	IEA
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IDA	10514444, 15369820, 16787387, 17279314
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IEA
GO:0005503	Function	All-trans retinal binding	IDA	15369820
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006066	Process	Alcohol metabolic process	IDA	3466164
GO:0006067	Process	Ethanol metabolic process	IEA
GO:0006081	Process	Aldehyde metabolic process	IDA	3466164
GO:0006081	Process	Aldehyde metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	10407146
GO:0008270	Function	Zinc ion binding	IEA
GO:0010430	Process	Fatty acid omega-oxidation	IDA	16081420
GO:0010430	Process	Fatty acid omega-oxidation	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IDA	3466164
GO:0019841	Function	Retinol binding	IDA	10407146
GO:0042572	Process	Retinol metabolic process	IDA	16787387, 17279314
GO:0046164	Process	Alcohol catabolic process	IEA
GO:0046164	Process	Alcohol catabolic process	ISS
GO:0046294	Process	Formaldehyde catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051287	Function	NAD binding	IDA	10407146
GO:0051903	Function	S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA
GO:1901661	Process	Quinone metabolic process	IEA
GO:1901661	Process	Quinone metabolic process	ISS

Other IDs

• MIM: 103740
• HGNC: 252
• e!Ensembl: ENSG00000198099

Protein

• UniProt ID: P08319
• Protein name: All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)
• Protein function: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end p
• PDB: 3COS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00107	ADH_zinc_N	208 → 340	Zinc-binding dehydrogenase	Family
  PF08240	ADH_N	34 → 166	Alcohol dehydrogenase GroES-like domain	Domain

• Sequence:

  MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
  LAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLK
  SPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGC
  GFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKA
  LGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV
  AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDK
  ISEAFDLMNQGKSVRTILIF

• Sequence length: 380

Pathways

KEGG Pathway	Reactome Pathway
Glycolysis / Gluconeogenesis	RA biosynthesis pathway
Fatty acid degradation	Ethanol oxidation
Tyrosine metabolism
Pyruvate metabolism
Retinol metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Metabolic pathways
Alcoholic liver disease

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (13)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	35663546	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	28284560	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CIC-rearranged sarcoma	not provided	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	35285134	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	35694926	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL CARCINOMA	—	GWAS catalog	22960999	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	35835914	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	29718361	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	23251661	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	33667223	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	35285134	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ADH1B 2 shared diseasesEsophageal cancer, Upper aerodigestive tract neoplasm 9 shared pathwaysGlycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Alcoholic liver disease, Ethanol oxidation 3 shared evidence sourcesGWAS catalog (Esophageal cancer), CTD (Nonalcoholic fatty liver disease), GWAS catalog (Upper aerodigestive tract neoplasm) Related via 9 shared pathways including Glycolysis / Gluconeogenesis, Fatty acid degradation — evidence mostly GWAS catalog. ADH1C 1 shared diseaseUpper aerodigestive tract neoplasm 10 shared pathwaysGlycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Alcoholic liver disease, RA biosynthesis pathway, Ethanol oxidation 1 shared evidence sourceGWAS catalog (Upper aerodigestive tract neoplasm) Related via 10 shared pathways including Glycolysis / Gluconeogenesis, Fatty acid degradation — evidence mostly GWAS catalog. ADH1A 10 shared pathwaysGlycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Alcoholic liver disease, RA biosynthesis pathway, Ethanol oxidation 1 shared evidence sourceCTD (Nonalcoholic fatty liver disease) Related via 10 shared pathways including Glycolysis / Gluconeogenesis, Fatty acid degradation — evidence mostly CTD. ADH7 1 shared diseaseUpper aerodigestive tract neoplasm 9 shared pathwaysGlycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Alcoholic liver disease, Ethanol oxidation 1 shared evidence sourceGWAS catalog (Upper aerodigestive tract neoplasm) Related via 9 shared pathways including Glycolysis / Gluconeogenesis, Fatty acid degradation — evidence mostly GWAS catalog. ADH6 9 shared pathwaysGlycolysis / Gluconeogenesis, Fatty acid degradation, Tyrosine metabolism, Pyruvate metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Alcoholic liver disease, Ethanol oxidation Related via 9 shared pathways including Glycolysis / Gluconeogenesis, Fatty acid degradation.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ADH1B	2	["Esophageal cancer","Upper aerodigestive tract neoplasm"]	9	["Glycolysis \/ Gluconeogenesis","Fatty acid degradation","Tyrosine metabolism","Pyruvate metabolism","Retinol metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Alcoholic liver disease","Ethanol oxidation"]	3	["GWAS catalog (Esophageal cancer)","CTD (Nonalcoholic fatty liver disease)","GWAS catalog (Upper aerodigestive tract neoplasm)"]
ADH1C	1	["Upper aerodigestive tract neoplasm"]	10	["Glycolysis \/ Gluconeogenesis","Fatty acid degradation","Tyrosine metabolism","Pyruvate metabolism","Retinol metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Alcoholic liver disease","RA biosynthesis pathway","Ethanol oxidation"]	1	["GWAS catalog (Upper aerodigestive tract neoplasm)"]
ADH1A	0	[]	10	["Glycolysis \/ Gluconeogenesis","Fatty acid degradation","Tyrosine metabolism","Pyruvate metabolism","Retinol metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Alcoholic liver disease","RA biosynthesis pathway","Ethanol oxidation"]	1	["CTD (Nonalcoholic fatty liver disease)"]
ADH7	1	["Upper aerodigestive tract neoplasm"]	9	["Glycolysis \/ Gluconeogenesis","Fatty acid degradation","Tyrosine metabolism","Pyruvate metabolism","Retinol metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Alcoholic liver disease","Ethanol oxidation"]	1	["GWAS catalog (Upper aerodigestive tract neoplasm)"]
ADH6	0	[]	9	["Glycolysis \/ Gluconeogenesis","Fatty acid degradation","Tyrosine metabolism","Pyruvate metabolism","Retinol metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Alcoholic liver disease","Ethanol oxidation"]	0	[]

Diseases Linked via Similar Genes

Hypertension Linked via 3 of 5 related genesADH1B, ADH1C, ADH7 Major depressive disorder Linked via 3 of 5 related genesADH1B, ADH1A, ADH7 Mouth neoplasms Linked via 3 of 5 related genesADH1B, ADH1C, ADH7 Oropharyngeal cancer Linked via 3 of 5 related genesADH1B, ADH1C, ADH7 Cerebral amyloid angiopathy Linked via 2 of 5 related genesADH1B, ADH1C

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hypertension	3	["ADH1B","ADH1C","ADH7"]
Major depressive disorder	3	["ADH1B","ADH1A","ADH7"]
Mouth neoplasms	3	["ADH1B","ADH1C","ADH7"]
Oropharyngeal cancer	3	["ADH1B","ADH1C","ADH7"]
Cerebral amyloid angiopathy	2	["ADH1B","ADH1C"]