Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	127
Gene name	Alcohol dehydrogenase 4 (class II), pi polypeptide
Gene symbol	ADH4
Synonyms (NCBI Gene)	ADH-2HEL-S-4
Chromosome	4
Chromosome location	4q23
Summary	This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxystero

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT549913	hsa-miR-376c-3p	PAR-CLIP	21572407
MIRT549912	hsa-miR-1265	PAR-CLIP	21572407
MIRT549911	hsa-miR-6841-5p	PAR-CLIP	21572407
MIRT549910	hsa-miR-4464	PAR-CLIP	21572407
MIRT549909	hsa-miR-4748	PAR-CLIP	21572407
MIRT549908	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT549907	hsa-miR-1286	PAR-CLIP	21572407
MIRT549906	hsa-miR-4722-5p	PAR-CLIP	21572407
MIRT549905	hsa-miR-3665	PAR-CLIP	21572407
MIRT549904	hsa-miR-657	PAR-CLIP	21572407
MIRT549903	hsa-miR-4764-5p	PAR-CLIP	21572407
MIRT549902	hsa-miR-5087	PAR-CLIP	21572407
MIRT549901	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT549900	hsa-miR-143-5p	PAR-CLIP	21572407
MIRT549899	hsa-miR-8068	PAR-CLIP	21572407
MIRT549898	hsa-miR-4666a-5p	PAR-CLIP	21572407
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT768628	hsa-miR-3907	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167643	hsa-miR-1236	CLIP-seq
MIRT2167644	hsa-miR-1298	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT768622	hsa-miR-30a	CLIP-seq
MIRT768623	hsa-miR-30b	CLIP-seq
MIRT768624	hsa-miR-30c	CLIP-seq
MIRT768625	hsa-miR-30d	CLIP-seq
MIRT768626	hsa-miR-30e	CLIP-seq
MIRT2167646	hsa-miR-338-3p	CLIP-seq
MIRT2167647	hsa-miR-3675-3p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2167648	hsa-miR-4286	CLIP-seq
MIRT2167649	hsa-miR-4786-3p	CLIP-seq
MIRT2167650	hsa-miR-885-5p	CLIP-seq
MIRT768627	hsa-miR-376c	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq
MIRT2443252	hsa-miR-199a-5p	CLIP-seq
MIRT2443253	hsa-miR-199b-5p	CLIP-seq
MIRT2167645	hsa-miR-2355-5p	CLIP-seq
MIRT2470329	hsa-miR-4282	CLIP-seq
MIRT2443254	hsa-miR-4302	CLIP-seq
MIRT2470330	hsa-miR-513a-3p	CLIP-seq
MIRT2470331	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IDA	15369820
GO:0003960	Function	Quinone reductase (NADPH) activity	IEA
GO:0003960	Function	Quinone reductase (NADPH) activity	ISS
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IBA
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IDA	3466164, 10407146, 16787387
GO:0004022	Function	Alcohol dehydrogenase (NAD+) activity	IEA
GO:0004032	Function	Aldose reductase (NADPH) activity	IEA
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IDA	10514444, 15369820, 16787387, 17279314
GO:0004745	Function	All-trans-retinol dehydrogenase (NAD+) activity	IEA
GO:0005503	Function	All-trans retinal binding	IDA	15369820
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006066	Process	Alcohol metabolic process	IDA	3466164
GO:0006067	Process	Ethanol metabolic process	IEA
GO:0006081	Process	Aldehyde metabolic process	IDA	3466164
GO:0006081	Process	Aldehyde metabolic process	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	10407146
GO:0008270	Function	Zinc ion binding	IEA
GO:0010430	Process	Fatty acid omega-oxidation	IDA	16081420
GO:0010430	Process	Fatty acid omega-oxidation	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0018479	Function	Benzaldehyde dehydrogenase (NAD+) activity	IDA	3466164
GO:0019841	Function	Retinol binding	IDA	10407146
GO:0042572	Process	Retinol metabolic process	IDA	16787387, 17279314
GO:0046164	Process	Alcohol catabolic process	IEA
GO:0046164	Process	Alcohol catabolic process	ISS
GO:0046294	Process	Formaldehyde catabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051287	Function	NAD binding	IDA	10407146
GO:0051903	Function	S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA
GO:1901661	Process	Quinone metabolic process	IEA
GO:1901661	Process	Quinone metabolic process	ISS

MIM	HGNC	e!Ensembl
103740	252	ENSG00000198099

P08319

Protein name

All-trans-retinol dehydrogenase [NAD(+)] ADH4 (EC 1.1.1.105) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 4) (Alcohol dehydrogenase class II pi chain)

Protein function

Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end p

PDB

3COS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08240	ADH_N	34 → 166	Alcohol dehydrogenase GroES-like domain	Domain
PF00107	ADH_zinc_N	208 → 340	Zinc-binding dehydrogenase	Family

Sequence

MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLK
SPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGC
GFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKA
LGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV
AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDK
ISEAFDLMNQGKSVRTILIF

Sequence length

380

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CIC-rearranged sarcoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide)