ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID 124
Gene name Alcohol dehydrogenase 1A (class I), alpha polypeptide
Gene symbol ADH1A
Synonyms (NCBI Gene)
ADH1
Chromosome 4
Chromosome location 4q23
Summary This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze
miRNA miRNA information provided by mirtarbase database.
4
Gene SNPs Transcription factors Other IDs Associated diseases
Show/Hide all (4)
miRTarBase ID miRNA Experiments Reference
MIRT021722 hsa-miR-132-3p Microarray 17612493
MIRT768615 hsa-miR-4468 CLIP-seq
MIRT768616 hsa-miR-4677-3p CLIP-seq
MIRT768617 hsa-miR-4679 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene SNPs Transcription factors Other IDs Associated diseases
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Transcription factor Regulation Reference
GATA2 Activation 16153155
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
Gene SNPs Transcription factors Other IDs Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity IDA 9982, 2738060
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity IEA
GO:0004745 Function All-trans-retinol dehydrogenase (NAD+) activity IBA
GO:0005515 Function Protein binding IPI 16153155
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
103700 249 ENSG00000187758
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P07327
Protein name Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase subunit alpha)
Protein function Alcohol dehydrogenase (PubMed:2738060). Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate (PubMed:2738060).
PDB 1HSO , 1U3T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08240 ADH_N 34 → 161 Alcohol dehydrogenase GroES-like domain Domain
PF00107 ADH_zinc_N 203 → 339 Zinc-binding dehydrogenase Family
Sequence
Sequence length 375
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene SNPs Transcription factors Other IDs Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (6)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (41)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Astrocytoma Astrocytoma BEFREE 21276435
★★★★★
★☆☆☆☆
Found in Text Mining only
Atypical Ductal Breast Hyperplasia Breast Hyperplasia BEFREE 23375686, 26818911
★★★★★
★☆☆☆☆
Found in Text Mining only
Autosomal dominant hypocalcemia Hypocalcemia BEFREE 26052899, 29846619, 31063613, 31820785
★★★★★
★☆☆☆☆
Found in Text Mining only
Benign Neoplasm Benign Neoplasm BEFREE 19077459
★★★★★
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 28261287
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 31292488, 33550915 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 30653870, 35236335, 36341373, 39193514, 40527777 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 33287761 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 21480392
★★★★★
★☆☆☆☆
Found in Text Mining only
Cataract Cataract Pubtator 22045060 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only