ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide)

Gene Gene information from NCBI Gene database.
Gene SNPs Other IDs Associated diseases
Entrez ID 131
Gene name Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Gene symbol ADH7
Synonyms (NCBI Gene)
ADH4
Chromosome 4
Chromosome location 4q23
Summary This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxyste
miRNA miRNA information provided by mirtarbase database.
9
Gene SNPs Other IDs Associated diseases
Show/Hide all (9)
miRTarBase ID miRNA Experiments Reference
MIRT018740 hsa-miR-335-5p Microarray 18185580
MIRT755738 hsa-miR-21-5p qRT-PCR 35235474
MIRT768708 hsa-miR-1 CLIP-seq
MIRT768709 hsa-miR-206 CLIP-seq
MIRT768710 hsa-miR-3545-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
Gene SNPs Other IDs Associated diseases
Show/Hide all (29)
GO ID Ontology Definition Evidence Reference
GO:0001523 Process Retinoid metabolic process IDA 9600267, 16787387
GO:0001523 Process Retinoid metabolic process IEA
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity IDA 7876099, 10969996
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity IEA
GO:0004022 Function Alcohol dehydrogenase (NAD+) activity TAS 8074657
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Other IDs Associated diseases
MIM HGNC e!Ensembl
600086 256 ENSG00000196344
Protein Protein information from UniProt database.
Gene SNPs Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P40394
Protein name All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.
Protein function Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9
PDB 1AGN , 1D1S , 1D1T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08240 ADH_N 46 → 172 Alcohol dehydrogenase GroES-like domain Domain
PF00107 ADH_zinc_N 214 → 350 Zinc-binding dehydrogenase Family
Tissue specificity TISSUE SPECIFICITY: Preferentially expressed in stomach.
Sequence
Sequence length 386
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Gene SNPs Other IDs Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (11)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ADH7-related disorder Uncertain significance; Likely benign; Benign ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EATING DISORDER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL NEOPLASMS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (76)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 29808834
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 32147670 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Sickle Cell Sickle cell anemia Pubtator 37712142 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Aniridia Aniridia BEFREE 30292490
★★★★★
★☆☆☆☆
Found in Text Mining only
Aniridia Aniridia Pubtator 34827649, 40570009 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma BEFREE 21276435
★★★★★
★☆☆☆☆
Found in Text Mining only
Benign Neoplasm Benign Neoplasm BEFREE 19077459
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 21480392 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 30628708, 30720105, 33287761, 33879119, 33988674, 34147074, 35892599, 36199423, 36341373, 36553522, 37248957, 37957550, 38025761, 40389832 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 21480392
★★★★★
★☆☆☆☆
Found in Text Mining only