Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006 [PubMed 16449189]).[s
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
Protein function
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoprotei
["Protein processing in endoplasmic reticulum","ABC-family proteins mediated transport","Defective CFTR causes cystic fibrosis","ER Quality Control Compartment (ERQC)"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to DERL2 (see Related Genes above), that are NOT already directly curated for DERL2 itself -- a lead worth checking, not a confirmed association.