Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
OPEN-ANGLE GLAUCOMA	EFO_0004190 MONDO:0005338	MYOCOS	Unknown	33627673 36777996 38382466 39024449	GWAS catalog	—
		NABP1	Unknown	38382466	GWAS catalog	RNA polymerase II transcribes snRNA genes
		NASP	Unknown	37386247	GWAS catalog	—
		NCKIPSD	Unknown	39024449	GWAS catalog	Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis
		NEDD4	Unknown	37386247	GWAS catalog	Ubiquitin mediated proteolysis Endocytosis Tight junction +6 more
		NEURL1B	Unknown	39024449	GWAS catalog	Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
		NFIA	Unknown	37386247	GWAS catalog	—
		NHERF2	Unknown	37386247	GWAS catalog	—
		NPAS2	Unknown	37386247	GWAS catalog	Circadian rhythm BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression +1 more
		NPC2	Unknown	37386247	GWAS catalog	Lysosome Cholesterol metabolism Neutrophil degranulation +1 more
		NPEPPS	Unknown	33627673 39024449	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		NR5A2	Unknown	37386247	GWAS catalog	Maturity onset diabetes of the young Nuclear Receptor transcription pathway SUMOylation of intracellular receptors +1 more
		NUDT7	Unknown	33627673 37386247	GWAS catalog	Peroxisome Peroxisomal lipid metabolism Peroxisomal protein import
		OLFM3	Unknown	29449654 36777996 37386247	GWAS catalog	—
		OR4C11	Unknown	37386247	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OR4C16	Unknown	37386247	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OR4C5	Unknown	37386247	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OR5B12	Unknown	38382466	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OR5B21	Unknown	38382466	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OSM	Unknown	37386247	GWAS catalog	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +2 more
		OTUD7B	Unknown	37386247 39024449	GWAS catalog	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway +1 more
		PARD3B	Unknown	37386247	GWAS catalog	—
		PARVA	Unknown	37386247	GWAS catalog	Focal adhesion Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions +1 more
		PCLO	Unknown	37386247 38382466	GWAS catalog	Insulin secretion
		PCSK5	Unknown	37386247	GWAS catalog	NGF processing Assembly of active LPL and LIPC lipase complexes
		PDE7B	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Purine metabolism Metabolic pathways Morphine addiction +1 more
		PDZD2	Unknown	39024449	GWAS catalog	—
		PIGC	Unknown	37386247	GWAS catalog	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)
		PKHD1	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	—
		PLCE1	Unknown	29891935 33627673 37386247 38382466 39024449	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Ras signaling pathway +9 more
		PLEKHA7	Unknown	33627673 36777996 37386247 38382466	GWAS catalog	—
		PLEKHS1	Unknown	37386247	GWAS catalog	—
		PLXND1	Unknown	37386247	GWAS catalog	Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription
		PMM2	Unknown	25173107	GWAS catalog	Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism Metabolic pathways +4 more
		PNPT1	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	RNA degradation
		POU6F2	Unknown	33627673 37386247 38382466	GWAS catalog	—
		PPP1R12B	Unknown	37386247	GWAS catalog	Vascular smooth muscle contraction Focal adhesion Regulation of actin cytoskeleton +5 more
		PRDM16	Unknown	37386247 39024449	GWAS catalog	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRICKLE2	Unknown	39024449	GWAS catalog	Wnt signaling pathway
		PRKAG2	Unknown	29891935 37386247	GWAS catalog	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +19 more
		PRKCE	Unknown	37386247	GWAS catalog	cGMP-PKG signaling pathway Sphingolipid signaling pathway Vascular smooth muscle contraction +14 more
		PRRC2A	Unknown	37386247	GWAS catalog	—
		PRSS23	Unknown	37386247 39024449	GWAS catalog	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		PRTFDC1	Unknown	37386247	GWAS catalog	—
		PTBP1	Unknown	37386247 39024449	GWAS catalog	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
		PTHLH	Unknown	33627673 37386247 38382466	GWAS catalog	Hormone signaling Parathyroid hormone synthesis, secretion and action Class B/2 (Secretin family receptors) +2 more
		PURG	Unknown	37386247	GWAS catalog	—
		RALGPS1	Unknown	37386247	GWAS catalog	—
		RAMP2	Unknown	—	GenCC	Hormone signaling Vascular smooth muscle contraction G alpha (s) signalling events +2 more
		RAPSN	Unknown	33627673 38382466	GWAS catalog	—

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Open angle glaucoma

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