Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
OPEN-ANGLE GLAUCOMA	EFO_0004190	RARB	Unknown	29891935 33627673 37386247 38382466 39024449	GWAS catalog	Pathways in cancer Small cell lung cancer Non-small cell lung cancer +3 more
		RELN	Unknown	37386247	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		RERE	Unknown	33627673 37386247	GWAS catalog	—
		RFLNA	Unknown	39024449	GWAS catalog	—
		RFX4	Unknown	37386247 39024449	GWAS catalog	—
		RORA	Unknown	29891935 33627673 37386247 38382466 39024449	GWAS catalog	Th17 cell differentiation Circadian rhythm Spinocerebellar ataxia +7 more
		RPE65	Unknown	39024449	GWAS catalog	Retinol metabolism Metabolic pathways The canonical retinoid cycle in rods (twilight vision)
		RPH3A	Unknown	37386247	GWAS catalog	—
		RSPO1	Unknown	33627673 37386247	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination
		RUNX1	Unknown	39024449	GWAS catalog	Tight junction Th17 cell differentiation Pathways in cancer +20 more
		RUNX2	Unknown	37386247	GWAS catalog	Parathyroid hormone synthesis, secretion and action Transcriptional misregulation in cancer Transcriptional regulation by RUNX2 +6 more
		SART3	Unknown	39024449	GWAS catalog	—
		SASH1	Unknown	39024449	GWAS catalog	—
		SCARF2	Unknown	37386247	GWAS catalog	—
		SCFD2	Unknown	33627673 37386247 38382466	GWAS catalog	—
		SEMA3C	Unknown	29891935 33627673 37386247 38382466	GWAS catalog	Axon guidance
		SEMA3E	Unknown	37386247 38382466	GWAS catalog	Axon guidance Other semaphorin interactions
		SEPTIN7	Unknown	33627673 37386247 38382466	GWAS catalog	Shigellosis MAPK6/MAPK4 signaling
		SIX5	Unknown	37386247	GWAS catalog	—
		SIX6	Unknown	26752265 33627673 37386247 38382466 39024449	GWAS catalog	—
		SLC24A5	Unknown	39024449	GWAS catalog	Sodium/Calcium exchangers Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)
		SLC2A12	Unknown	36777996 37386247 38382466	GWAS catalog	Cellular hexose transport
		SLC30A10	Unknown	37386247	GWAS catalog	Metal ion SLC transporters
		SLC38A11	Unknown	37386247	GWAS catalog	—
		SLC40A1	Unknown	37386247	GWAS catalog	Hormone signaling Ferroptosis Mineral absorption +5 more
		SLC6A15	Unknown	29891935 33627673 37386247 38382466 39024449	GWAS catalog	Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters
		SLCO3A1	Unknown	37386247	GWAS catalog	Transport of organic anions
		SMAD6	Unknown	33627673 37386247 38382466	GWAS catalog	TGF-beta signaling pathway Signaling by BMP RUNX2 regulates bone development
		SMG6	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	mRNA surveillance pathway Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
		SORCS2	Unknown	29452408	GWAS catalog	—
		SOS2	Unknown	37386247	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +49 more
		SPI1	Unknown	37386247	GWAS catalog	Osteoclast differentiation Human T-cell leukemia virus 1 infection Pathways in cancer +3 more
		SPTBN1	Unknown	37386247	GWAS catalog	Cytoskeleton in muscle cells NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins +2 more
		SRSF3	Unknown	33627673 37386247 38382466 39024449	GWAS catalog	Spliceosome Amyotrophic lateral sclerosis Herpes simplex virus 1 infection +4 more
		ST7L	Unknown	37386247	GWAS catalog	—
		STK38	Unknown	33627673 38382466	GWAS catalog	—
		STOX2	Unknown	37386247 38382466	GWAS catalog	—
		STRIP1	Unknown	37386247	GWAS catalog	—
		SVEP1	Unknown	33627673	GWAS catalog	—
		SYN3	Unknown	37386247	GWAS catalog	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
		SYNDIG1L	Unknown	37386247	GWAS catalog	—
		SYNE3	Unknown	36777996 37386247 38382466	GWAS catalog	Cytoskeleton in muscle cells
		TAF4	Unknown	37386247	GWAS catalog	Basal transcription factors Huntington disease RNA Polymerase II Pre-transcription Events +5 more
		TAL1	Unknown	37386247	GWAS catalog	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBC1D13	Unknown	37386247	GWAS catalog	TBC/RABGAPs
		TCF12	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF7	Unknown	37386247	GWAS catalog	Wnt signaling pathway Hippo signaling pathway Adherens junction +24 more
		TCF7L2	Unknown	37386247	GWAS catalog	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TES	Unknown	37386247	GWAS catalog	—
		TESK2	Unknown	37386247	GWAS catalog	—

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Open angle glaucoma

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