Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
OPEN-ANGLE GLAUCOMA	EFO_0004190	ITIH1	Unknown	25173105	GWAS catalog	—
		ITPR2	Unknown	37386247	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Phosphatidylinositol signaling system +48 more
		JAKMIP2	Unknown	37386247	GWAS catalog	—
		KALRN	Unknown	37386247 38382466	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling +3 more
		KANK2	Unknown	37386247	GWAS catalog	—
		KBTBD8	Unknown	37386247 38382466 39024449	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		KCNK5	Unknown	37386247 38382466	GWAS catalog	Taste transduction Protein digestion and absorption Phase 4 - resting membrane potential
		KIAA1549L	Unknown	39024449	GWAS catalog	—
		KIF11	Unknown	37386247	GWAS catalog	Motor proteins MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic +1 more
		KLF5	Unknown	33627673 37386247	GWAS catalog	Chemical carcinogenesis - receptor activation
		LHPP	Unknown	33627673 37386247	GWAS catalog	Oxidative phosphorylation Purine ribonucleoside monophosphate biosynthesis
		LINC02210-CRHR1	Unknown	37386247	GWAS catalog	Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
		LMO7	Unknown	29449654 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Adherens junction Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		LMX1B	Unknown	29891935 33627673 37386247 39024449	GWAS catalog	—
		LOXL1	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	Elastic fibre formation Crosslinking of collagen fibrils
		LPP	Unknown	29891935 33627673 36777996 37386247 38382466	GWAS catalog	—
		LPXN	Unknown	37386247	GWAS catalog	—
		LRMDA	Unknown	37386247	GWAS catalog	—
		LRRC27	Unknown	31937794	GWAS catalog	—
		LSM8	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	RNA degradation Spliceosome mRNA Splicing - Major Pathway
		LTBP1	Unknown	37386247	GWAS catalog	TGF-beta signaling pathway Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
		LTBP2	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	Molecules associated with elastic fibres
		LTBP3	Unknown	38382466 39024449	GWAS catalog	Molecules associated with elastic fibres
		LTO1	Unknown	37386247	GWAS catalog	—
		LYPLAL1	Unknown	39024449	GWAS catalog	—
		MAD1L1	Unknown	38382466	GWAS catalog	Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation +8 more
		MADD	Unknown	29891935	GWAS catalog	Regulation of TNFR1 signaling RAB GEFs exchange GTP for GDP on RABs
		MAPT	Unknown	33627673	GWAS catalog	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MAT1A	Unknown	37386247	GWAS catalog	Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways +6 more
		MCPH1	Unknown	37386247	GWAS catalog	Condensation of Prophase Chromosomes
		ME3	Unknown	33627673 37386247 38382466 39024449	GWAS catalog	Pyruvate metabolism Metabolic pathways Carbon metabolism +2 more
		MECOM	Unknown	33627673 37386247 38382466	GWAS catalog	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MEIOSIN	Unknown	37386247	GWAS catalog	—
		MET	Unknown	37386247	GWAS catalog	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		METTL15	Unknown	37386247	GWAS catalog	—
		MGAT5	Unknown	22419738	GWAS catalog	N-Glycan biosynthesis Metabolic pathways N-Glycan antennae elongation
		MICAL3	Unknown	37386247	GWAS catalog	—
		MINAR2	Unknown	37386247	GWAS catalog	—
		MLLT3	Unknown	39024449	GWAS catalog	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MOV10	Unknown	33627673 37386247 38382466	GWAS catalog	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence +11 more
		MPP7	Unknown	27001270	GWAS catalog	—
		MSI2	Unknown	37386247	GWAS catalog	mRNA surveillance pathway
		MTMR11	Unknown	39024449	GWAS catalog	—
		MTOR	Unknown	36777996	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MTUS1	Unknown	37386247 39024449	GWAS catalog	—
		MVB12B	Unknown	33627673	GWAS catalog	Endocytosis Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins +2 more
		MYH13	Unknown	37386247	GWAS catalog	Motor proteins Cytoskeleton in muscle cells
		MYL4	Unknown	37386247	GWAS catalog	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway +3 more
		MYO16	Unknown	37386247 39024449	GWAS catalog	Motor proteins
		MYO1B	Unknown	38382466	GWAS catalog	Motor proteins Pathogenic Escherichia coli infection
PRIMARY OPEN ANGLE GLAUCOMA	C0339573	LOXL1	Unknown	—	Disgenet	Elastic fibre formation Crosslinking of collagen fibrils

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Open angle glaucoma

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