Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
OPEN-ANGLE GLAUCOMA	EFO_0004190	EMCN	Unknown	37386247	GWAS catalog	—
		EMID1	Unknown	37386247	GWAS catalog	—
		ENDOG	Unknown	37386247	GWAS catalog	Apoptosis
		ERG	Unknown	37386247	GWAS catalog	Transcriptional misregulation in cancer Prostate cancer
		ETS1	Unknown	33627673 37386247 38382466	GWAS catalog	Ras signaling pathway Cellular senescence Human T-cell leukemia virus 1 infection +3 more
		EXOC2	Unknown	29891935 33627673 37386247 39024449	GWAS catalog	Ras signaling pathway Salmonella infection Insulin processing +1 more
		EXOC6	Unknown	37386247	GWAS catalog	Insulin processing VxPx cargo-targeting to cilium
		EYA2	Unknown	33627673 37386247 39024449	GWAS catalog	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		FAM13A	Unknown	33627673 37386247	GWAS catalog	Rho GTPase cycle
		FANCA	Unknown	37386247	GWAS catalog	Fanconi anemia pathway Fanconi Anemia Pathway
		FARS2	Unknown	27001270	GWAS catalog	Aminoacyl-tRNA biosynthesis Mitochondrial tRNA aminoacylation
		FAT4	Unknown	37386247	GWAS catalog	Hippo signaling pathway - multiple species
		FBXL17	Unknown	37386247	GWAS catalog	—
		FBXO32	Unknown	29891935 33627673 37386247 38382466 39024449	GWAS catalog	FoxO signaling pathway Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FERMT2	Unknown	36777996 37386247 38382466	GWAS catalog	Cell-extracellular matrix interactions
		FGF19	Unknown	37386247	GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +19 more
		FHL3	Unknown	37386247	GWAS catalog	Cytoskeleton in muscle cells
		FLI1	Unknown	37386247	GWAS catalog	Transcriptional misregulation in cancer
		FLNB	Unknown	37386247 39024449	GWAS catalog	Focal adhesion ISG15 antiviral mechanism
		FMNL2	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Cytoskeleton in muscle cells RHO GTPases Activate Formins
		FNDC3B	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	—
		FOXP4	Unknown	37386247	GWAS catalog	—
		GABPA	Unknown	33627673 37386247 38382466	GWAS catalog	Transcriptional activation of mitochondrial biogenesis
		GAS7	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	—
		GJD2	Unknown	37386247	GWAS catalog	Gap junction Electric Transmission Across Gap Junctions Gap junction assembly
		GLIS1	Unknown	33627673 37386247 38382466	GWAS catalog	—
		GLIS3	Unknown	37386247	GWAS catalog	—
		GLYAT	Unknown	37386247	GWAS catalog	Conjugation of salicylate with glycine Conjugation of benzoate with glycine
		GMDS	Unknown	25173105 29891935 33627673 37386247	GWAS catalog	Fructose and mannose metabolism Biosynthesis of various nucleotide sugars Metabolic pathways +2 more
		GNB1L	Unknown	29891935 39024449	GWAS catalog	—
		GNB3	Unknown	37386247 39024449	GWAS catalog	Ras signaling pathway Chemokine signaling pathway Hormone signaling +45 more
		GNL2	Unknown	38382466	GWAS catalog	Ribosome biogenesis in eukaryotes
		GPM6B	Unknown	33627673 38382466	GWAS catalog	—
		GSX2	Unknown	37386247	GWAS catalog	—
		GTF2E2	Unknown	33627673 36777996 37386247 38382466	GWAS catalog	Basal transcription factors Viral carcinogenesis RNA Polymerase II Pre-transcription Events +5 more
		H1-0	Unknown	33627673 37386247 39024449	GWAS catalog	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HERC2	Unknown	37386247	GWAS catalog	Ubiquitin mediated proteolysis SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +4 more
		HLA-G	Unknown	33627673 37386247	GWAS catalog	Endocytosis Phagosome Cellular senescence +22 more
		HMGA2	Unknown	37386247	GWAS catalog	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HMGXB3	Unknown	38382466	GWAS catalog	—
		HNRNPA1L3	Unknown	33627673 37386247 38382466 39024449	GWAS catalog	—
		HORMAD2	Unknown	37386247	GWAS catalog	—
		HSF2	Unknown	37386247	GWAS catalog	—
		HSPA12A	Unknown	37386247 39024449	GWAS catalog	Regulation of HSF1-mediated heat shock response
		IFT43	Unknown	37386247	GWAS catalog	Intraflagellar transport
		IGF1	Unknown	37386247	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IL34	Unknown	37386247	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Other interleukin signaling
		INTU	Unknown	37386247 38382466	GWAS catalog	Hedgehog 'off' state
		IQGAP1	Unknown	33627673	GWAS catalog	Adherens junction Regulation of actin cytoskeleton Proteoglycans in cancer +9 more
		ITGB3	Unknown	27001270 37386247	GWAS catalog	Virion - Herpesvirus Rap1 signaling pathway Hormone signaling +39 more

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Open angle glaucoma

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