Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
OPEN-ANGLE GLAUCOMA	EFO_0004190 MONDO:0005338	BNIP1	Unknown	29891935	GWAS catalog	SNARE interactions in vesicular transport COPI-dependent Golgi-to-ER retrograde traffic
		C12ORF75	Unknown	38382466	GWAS catalog	—
		C14ORF39	Unknown	22419738 22570617 25173105 26752265 29452408 29891935 33627673 37386247 38382466 39024449	GWAS catalog	—
		CADM2	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Adherens junctions interactions
		CALD1	Unknown	33627673 37386247	GWAS catalog	Vascular smooth muscle contraction Smooth Muscle Contraction
		CALN1	Unknown	40465716	GWAS catalog	—
		CATSPERB	Unknown	38382466	GWAS catalog	Sperm Motility And Taxes
		CAV1	Unknown	20835238 25173105 29891935 33627673 37386247 38382466 39024449	GWAS catalog	Endocytosis Focal adhesion Prion disease +11 more
		CAV2	Unknown	20835238 25173105 29891935 33627673 37386247 38382466 39024449	GWAS catalog	Endocytosis Focal adhesion Prion disease +4 more
		CCDC13	Unknown	38382466	GWAS catalog	—
		CCDC3	Unknown	37386247	GWAS catalog	—
		CCDC91	Unknown	33627673 37386247 38382466	GWAS catalog	—
		CD109	Unknown	37386247	GWAS catalog	Platelet degranulation Post-translational modification: synthesis of GPI-anchored proteins
		CDC42BPA	Unknown	39024449	GWAS catalog	—
		CDCA3	Unknown	37386247 39024449	GWAS catalog	—
		CDH11	Unknown	33627673 37386247 38382466 39024449	GWAS catalog	Adherens junctions interactions
		CDH23	Unknown	37386247	GWAS catalog	—
		CDKN2B	Unknown	22419738	GWAS catalog	FoxO signaling pathway Cell cycle Cellular senescence +12 more
		CELF2	Unknown	33627673 37386247 38382466	GWAS catalog	—
		CHEK2	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CIMIP6	Unknown	37386247	GWAS catalog	—
		CLIC5	Unknown	37386247 38382466	GWAS catalog	—
		CNBD1	Unknown	39024449	GWAS catalog	—
		COL11A1	Unknown	29449654 29891935 36777996 37386247 38382466	GWAS catalog	Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation +5 more
		COL16A1	Unknown	37386247 39024449	GWAS catalog	Protein digestion and absorption Collagen biosynthesis and modifying enzymes Integrin cell surface interactions +1 more
		COL24A1	Unknown	37386247	GWAS catalog	Cytoskeleton in muscle cells Protein digestion and absorption Collagen biosynthesis and modifying enzymes +3 more
		COL4A1	Unknown	37386247	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		COL8A1	Unknown	37386247 39024449	GWAS catalog	Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes +3 more
		COL8A2	Unknown	38382466	GWAS catalog	Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes +3 more
		CREB5	Unknown	37386247	GWAS catalog	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +31 more
		CRIPTO3	Unknown	33627673 38382466	GWAS catalog	—
		CROCC2	Unknown	37386247	GWAS catalog	—
		CSNK2A2IP	Unknown	37386247 39024449	GWAS catalog	—
		CTTNBP2	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	—
		DDR2	Unknown	33627673 37386247	GWAS catalog	Non-integrin membrane-ECM interactions
		DGKB	Unknown	39024449	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
		DGKD	Unknown	29891935	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
		DGKG	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
		DHRS3	Unknown	37386247	GWAS catalog	Retinol metabolism Metabolic pathways Biosynthesis of cofactors +2 more
		DLEU7	Unknown	37386247	GWAS catalog	—
		DNM3	Unknown	37386247	GWAS catalog	Phospholipase D signaling pathway Endocytosis Synaptic vesicle cycle +6 more
		DRAP1	Unknown	37386247	GWAS catalog	Signaling by NODAL Signaling by Activin
		DST	Unknown	30317457	GWAS catalog	Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly
		DUSP1	Unknown	39024449	GWAS catalog	MAPK signaling pathway Serotonergic synapse Parkinson disease +3 more
		EEF1AKMT2	Unknown	37386247	GWAS catalog	Protein methylation
		EFEMP1	Unknown	26162006 29891935 32476818 33627673 34923728 35490425 35946471 36777996 37386247 38083999 38382466 38467175 39024449 39264138	ClinGen, GWAS catalog	Molecules associated with elastic fibres
		EFHC2	Unknown	33627673 38382466	GWAS catalog	—
		EGLN3	Unknown	37386247 38382466	GWAS catalog	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +1 more
		EHMT2	Unknown	37386247	GWAS catalog	Lysine degradation Metabolic pathways Longevity regulating pathway +6 more
		EIF3L	Unknown	38382466	GWAS catalog	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits +3 more
PRIMARY OPEN ANGLE GLAUCOMA	C0339573	CAV1	Unknown	—	Disgenet	Endocytosis Focal adhesion Prion disease +11 more
PRIMARY OPEN ANGLE GLAUCOMA	C0339573	CAV2	Unknown	—	Disgenet	Endocytosis Focal adhesion Prion disease +4 more

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Open angle glaucoma

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