Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
OPEN-ANGLE GLAUCOMA	EFO_0004190 MONDO:0005338	TET1	Unknown	37386247	GWAS catalog	—
		TFAP2B	Unknown	37386247	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
		TFEC	Unknown	37386247	GWAS catalog	—
		THSD4	Unknown	37386247	GWAS catalog	TGF-beta signaling pathway Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		THSD7A	Unknown	29891935 33627673 36777996 37386247 38382466	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		TLCD5	Unknown	33627673	GWAS catalog	—
		TLE3	Unknown	37386247	GWAS catalog	Wnt signaling pathway Notch signaling pathway Formation of the beta-catenin:TCF transactivating complex +3 more
		TM2D1	Unknown	37386247	GWAS catalog	—
		TMCO1	Unknown	25173105 26752265 29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	—
		TMEM119	Unknown	37386247	GWAS catalog	—
		TMEM135	Unknown	37386247	GWAS catalog	—
		TMEM181	Unknown	29891935 37386247 38382466	GWAS catalog	—
		TNR	Unknown	37386247	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		TNS1	Unknown	37386247	GWAS catalog	—
		TP53BP2	Unknown	—	ClinGen	Hippo signaling pathway Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release +3 more
		TRAF3IP1	Unknown	37386247	GWAS catalog	Intraflagellar transport
		TRAPPC3	Unknown	33627673 37386247	GWAS catalog	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
		TRIB2	Unknown	37386247 38382466 39024449	GWAS catalog	—
		TRIM51G	Unknown	37386247	GWAS catalog	—
		TRIM71	Unknown	37386247	GWAS catalog	MicroRNAs in cancer Antigen processing: Ubiquitination & Proteasome degradation
		TRIOBP	Unknown	33627673 37386247 39024449	GWAS catalog	—
		TSEN15	Unknown	37386247	GWAS catalog	tRNA processing in the nucleus
		TSGA10IP	Unknown	37386247	GWAS catalog	—
		TSPAN11	Unknown	37386247	GWAS catalog	—
		TSPAN18	Unknown	37386247	GWAS catalog	—
		TSPAN4	Unknown	37386247	GWAS catalog	—
		TTLL5	Unknown	37386247	GWAS catalog	Carboxyterminal post-translational modifications of tubulin
		TXNRD2	Unknown	26752265 29891935 33627673 37386247 38382466 39024449	GWAS catalog	Selenocompound metabolism Pathways in cancer Hepatocellular carcinoma +1 more
		TYR	Unknown	37386247	GWAS catalog	Tyrosine metabolism Metabolic pathways Melanogenesis +1 more
		UMPS	Unknown	37386247	GWAS catalog	Pyrimidine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		VAV2	Unknown	37386247 39024449	GWAS catalog	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +24 more
		VCAM1	Unknown	38382466	GWAS catalog	NF-kappa B signaling pathway Cell adhesion molecules TNF signaling pathway +10 more
		VDAC1	Unknown	37386247	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Necroptosis +19 more
		WNT3	Unknown	38382466	GWAS catalog	mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway +15 more
		WNT9B	Unknown	37386247	GWAS catalog	mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway +13 more
		YAP1	Unknown	37386247	GWAS catalog	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		ZC3H11B	Unknown	37386247	GWAS catalog	—
		ZFP36L2	Unknown	37386247	GWAS catalog	Cellular senescence
		ZFPM2	Unknown	22570617	GWAS catalog	MicroRNAs in cancer Factors involved in megakaryocyte development and platelet production
		ZNF280D	Unknown	29891935	GWAS catalog	—
		ZNF366	Unknown	37386247	GWAS catalog	—
		ZNF516	Unknown	37386247	GWAS catalog	Thermogenesis
		ZNF638	Unknown	37386247	GWAS catalog	—
		ZNF652	Unknown	37386247	GWAS catalog	—
PRIMARY OPEN ANGLE GLAUCOMA	C0339573	ACVR1	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		ADIPOQ	Unknown	—	Disgenet	PPAR signaling pathway Hormone signaling AMPK signaling pathway +7 more
		ADRB2	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +13 more
		APOE	Unknown	—	Disgenet	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
		CARD10	Unknown	—	Disgenet	NF-kappa B signaling pathway
		CDKN1A	Unknown	—	Disgenet	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more

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Open angle glaucoma

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