Mood disorder

Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation Prostate cancer HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation +7 more

MAPK signaling pathway Chemokine signaling pathway Endocytosis Hedgehog signaling pathway Dopaminergic synapse Olfactory transduction Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action GnRH secretion Morphine addiction Chemical carcinogenesis - receptor activation G alpha (s) signalling events Thrombin signalling through proteinase activated receptors (PARs) WNT5A-dependent internalization of FZD4 Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants +21 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Osteoclast differentiation Thyroid hormone signaling pathway Pancreatic secretion Alzheimer disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +16 more

Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Vascular smooth muscle contraction Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) +5 more

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Huntington disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Alcoholism Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 activates RAC1 +9 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Taste transduction Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +34 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cellular senescence Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Tight junction Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Carbohydrate digestion and absorption Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +35 more

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Cholinergic synapse Regulation of actin cytoskeleton Muscarinic acetylcholine receptors G alpha (i) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +7 more

Circadian rhythm Dopaminergic synapse BMAL1:CLOCK,NPAS2 activates circadian gene expression

Steroid hormone biosynthesis Tyrosine metabolism Metabolic pathways Dopaminergic synapse Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase +4 more

cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes Osteoclast differentiation Antigen processing and presentation TNF signaling pathway Circadian rhythm Circadian entrainment Thermogenesis Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Insulin resistance Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Huntington disease Prion disease Cocaine addiction Amphetamine addiction Alcoholism Tuberculosis Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Viral carcinogenesis Chemical carcinogenesis - receptor activation Prostate cancer AKT phosphorylates targets in the nucleus CREB phosphorylation Transcriptional activation of mitochondrial biogenesis NCAM signaling for neurite out-growth Circadian Clock CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Constitutive Signaling by AKT1 E17K in Cancer Gastrin-CREB signalling pathway via PKC and MAPK NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +53 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Long-term depression Cushing syndrome Alcoholism Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +6 more

Class B/2 (Secretin family receptors)

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Long-term depression Cushing syndrome Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +5 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Cushing syndrome Class B/2 (Secretin family receptors) G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production +5 more

Human T-cell leukemia virus 1 infection Transcriptional activation of mitochondrial biogenesis Circadian Clock

Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Endocrine resistance Serotonergic synapse Fatty acids Miscellaneous substrates Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs +6 more

Glycine, serine and threonine metabolism Arginine and proline metabolism D-Amino acid metabolism Metabolic pathways Peroxisome Glyoxylate metabolism and glycine degradation Peroxisomal protein import +4 more

Tyrosine metabolism Metabolic pathways Catecholamine biosynthesis

Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Salmonella infection MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes XBP1(S) activates chaperone genes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2 +15 more

Hippo signaling pathway Tight junction Human papillomavirus infection Unblocking of NMDA receptors, glutamate binding and activation Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules +5 more

Hippo signaling pathway Glutamatergic synapse Huntington disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Activation of Ca-permeable Kainate Receptor RHO GTPases activate CIT RAF/MAP kinase cascade LGI-ADAM interactions Neurexins and neuroligins Synaptic adhesion-like molecules +10 more

Cysteine and methionine metabolism Metabolic pathways MicroRNAs in cancer PRC2 methylates histones and DNA SUMOylation of DNA methylation proteins +2 more

Cysteine and methionine metabolism Metabolic pathways MicroRNAs in cancer PRC2 methylates histones and DNA SUMOylation of DNA methylation proteins +2 more

Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse Dopamine receptors G alpha (i) signalling events +2 more

Neuroactive ligand-receptor interaction Hormone signaling Dopaminergic synapse Dopamine receptors G alpha (i) signalling events +2 more

Golgi Associated Vesicle Biogenesis

MAPK signaling pathway Transcriptional misregulation in cancer Acute myeloid leukemia RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway +3 more

Transcriptional misregulation in cancer

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Melanoma Breast cancer Gastric cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer +56 more

Estrogen signaling pathway HSP90 chaperone cycle for steroid hormone receptors (SHR) ESR-mediated signaling

Osteoclast differentiation IL-17 signaling pathway Cocaine addiction Amphetamine addiction Alcoholism Estrogen-dependent gene expression NGF-stimulated transcription +4 more

Reversal of alkylation damage by DNA dioxygenases

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Taste transduction Morphine addiction Nicotine addiction GABA receptor activation +4 more

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Taste transduction Morphine addiction Nicotine addiction GABA receptor activation +4 more

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Taste transduction Morphine addiction Nicotine addiction GABA receptor activation +4 more

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling Serotonergic synapse GABAergic synapse Morphine addiction Nicotine addiction GABA receptor activation +4 more

Neuroactive ligand-receptor interaction Retrograde endocannabinoid signaling GABAergic synapse Morphine addiction Nicotine addiction +2 more

Alanine, aspartate and glutamate metabolism beta-Alanine metabolism Taurine and hypotaurine metabolism Butanoate metabolism Metabolic pathways GABAergic synapse Type I diabetes mellitus GABA synthesis GABA synthesis, release, reuptake and degradation +6 more

Alanine, aspartate and glutamate metabolism beta-Alanine metabolism Taurine and hypotaurine metabolism Butanoate metabolism Metabolic pathways GABAergic synapse Type I diabetes mellitus GABA synthesis GABA synthesis, release, reuptake and degradation +6 more

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events

L1CAM interactions

Arginine biosynthesis Alanine, aspartate and glutamate metabolism Glyoxylate and dicarboxylate metabolism Nitrogen metabolism Metabolic pathways Biosynthesis of amino acids Necroptosis Glutamatergic synapse GABAergic synapse Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism +8 more

Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Taste transduction Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +45 more

Neuroactive ligand-receptor interaction

Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor +1 more