Mood disorder

Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism Linoleic acid metabolism alpha-Linolenic acid metabolism Metabolic pathways Ras signaling pathway Vascular smooth muscle contraction Pancreatic secretion Fat digestion and absorption Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA +13 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +2 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (i) signalling events +1 more

Base excision repair

PPAR signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Osteoclast differentiation Thermogenesis Non-alcoholic fatty liver disease Huntington disease Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Lipid and atherosclerosis PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of PTEN gene transcription +13 more

Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling PI3K-Akt signaling pathway JAK-STAT signaling pathway Prolactin signaling pathway Prolactin receptor signaling Amyloid fiber formation Growth hormone receptor signaling +6 more

Ferroptosis Prion disease Pathways of neurodegeneration - multiple diseases Insertion of tail-anchored proteins into the endoplasmic reticulum membrane +1 more

Peptide ligand-binding receptors G alpha (q) signalling events

Peptide ligand-binding receptors G alpha (q) signalling events

Arachidonic acid metabolism Metabolic pathways NF-kappa B signaling pathway Efferocytosis VEGF signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Retrograde endocannabinoid signaling Serotonergic synapse Ovarian steroidogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Alzheimer disease Pathways of neurodegeneration - multiple diseases Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Chemical carcinogenesis - DNA adducts MicroRNAs in cancer Small cell lung cancer Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives +29 more

Th17 cell differentiation Estrogen signaling pathway Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Transcriptional regulation of granulopoiesis +6 more

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Nucleocytoplasmic transport mRNA surveillance pathway Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +4 more

Salmonella infection Dissolution of Fibrin Clot

Nuclear signaling by ERBB4 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +1 more

Arginine and proline metabolism Metabolic pathways Ferroptosis Interconversion of polyamines +1 more

Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation +4 more

Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases

Nicotinate and nicotinamide metabolism Metabolic pathways FoxO signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Wnt signaling pathway Glucagon signaling pathway Alcoholic liver disease Amphetamine addiction MicroRNAs in cancer Regulation of HSF1-mediated heat shock response SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation +13 more

GABAergic synapse Cation-coupled Chloride cotransporters

Synaptic vesicle cycle Glutamatergic synapse Amyotrophic lateral sclerosis Huntington disease Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides +4 more

Cholinergic synapse Choline metabolism in cancer Acetylcholine Neurotransmitter Release Cycle Transport of bile salts and organic acids, metal ions and amine compounds Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) +2 more

Synaptic vesicle cycle Na+/Cl- dependent neurotransmitter transporters Defective SLC6A2 causes orthostatic intolerance (OI)

Synaptic vesicle cycle Dopaminergic synapse Parkinson disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Alcoholism Dopamine clearance from the synaptic cleft Na+/Cl- dependent neurotransmitter transporters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) +7 more

Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft

Arginine and proline metabolism beta-Alanine metabolism Metabolic pathways PAOs oxidise polyamines to amines Interconversion of polyamines +2 more

Cysteine and methionine metabolism Arginine and proline metabolism Glutathione metabolism Metabolic pathways Metabolism of polyamines +2 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation +2 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action Gastric acid secretion Peptide ligand-binding receptors G alpha (i) signalling events +4 more

Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action Peptide ligand-binding receptors G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium +3 more

Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events

Calcium signaling pathway Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +3 more

TBC/RABGAPs

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Cell cycle Efferocytosis Cellular senescence TGF-beta signaling pathway Osteoclast differentiation Hippo signaling pathway Th17 cell differentiation Intestinal immune network for IgA production Relaxin signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Inflammatory bowel disease Rheumatoid arthritis Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF +49 more

Tyrosine metabolism Folate biosynthesis Metabolic pathways Dopaminergic synapse Prolactin signaling pathway Parkinson disease Cocaine addiction Amphetamine addiction Alcoholism Catecholamine biosynthesis +7 more

Processing of DNA double-strand break ends

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway Sphingolipid signaling pathway mTOR signaling pathway Apoptosis Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer Asthma Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Hypertrophic cardiomyopathy Dilated cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling +72 more

Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Intestinal immune network for IgA production Rheumatoid arthritis TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway +4 more

Tryptophan metabolism Folate biosynthesis Metabolic pathways Serotonergic synapse Serotonin and melatonin biosynthesis NGF-stimulated transcription +3 more

Tryptophan metabolism Folate biosynthesis Metabolic pathways Serotonergic synapse Serotonin and melatonin biosynthesis +2 more

Small interfering RNA (siRNA) biogenesis

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Focal adhesion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Pancreatic cancer Bladder cancer Rheumatoid arthritis Fluid shear stress and atherosclerosis Platelet degranulation Regulation of gene expression by Hypoxia-inducible Factor Signaling by VEGF VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Interleukin-4 and Interleukin-13 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors +30 more

Neuroactive ligand-receptor interaction Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation NGF-stimulated transcription +1 more

Protein processing in endoplasmic reticulum XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more