Mood disorder

Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Glutamatergic synapse Dopaminergic synapse Alzheimer disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Systemic lupus erythematosus Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors +19 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +3 more

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway Cell cycle mTOR signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Hedgehog signaling pathway Axon guidance Hippo signaling pathway Focal adhesion Signaling pathways regulating pluripotency of stem cells IL-17 signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Neurotrophin signaling pathway Dopaminergic synapse Insulin signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Insulin resistance Non-alcoholic fatty liver disease Cushing syndrome Growth hormone synthesis, secretion and action Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Shigellosis Yersinia infection Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Lipid and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer +59 more

cAMP signaling pathway Taste transduction HCN channels

Neuroactive ligand-receptor interaction Hormone signaling Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events +1 more

ATP-dependent chromatin remodeling Polycomb repressive complex Cell cycle Longevity regulating pathway - multiple species Notch signaling pathway TGF-beta signaling pathway Neutrophil extracellular trap formation Thyroid hormone signaling pathway Huntington disease Amphetamine addiction Alcoholism Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Chronic myeloid leukemia G0 and Early G1 Formation of the beta-catenin:TCF transactivating complex Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Deactivation of the beta-catenin transactivating complex SUMOylation of chromatin organization proteins Repression of WNT target genes Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN gene transcription Estrogen-dependent gene expression Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity Factors involved in megakaryocyte development and platelet production +34 more

ATP-dependent chromatin remodeling Polycomb repressive complex Cell cycle Longevity regulating pathway - multiple species Notch signaling pathway TGF-beta signaling pathway Neutrophil extracellular trap formation Thyroid hormone signaling pathway Huntington disease Amphetamine addiction Alcoholism Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Chronic myeloid leukemia Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of MECP2 expression and activity EGR2 and SOX10-mediated initiation of Schwann cell myelination Factors involved in megakaryocyte development and platelet production +26 more

Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis MicroRNAs in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX3 regulates p14-ARF +8 more

Human papillomavirus infection

HIF-1 signaling pathway Mitophagy - animal Autophagy - animal Efferocytosis Th17 cell differentiation Thyroid hormone signaling pathway Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Regulation of gene expression by Hypoxia-inducible Factor Cellular response to hypoxia Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling PTK6 Expression PTK6 promotes HIF1A stabilization Neddylation +19 more

Scavenging of heme from plasma Neutrophil degranulation

Glutathione metabolism Arachidonic acid metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX) +5 more

Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis Antigen processing and presentation NOD-like receptor signaling pathway IL-17 signaling pathway Th17 cell differentiation Progesterone-mediated oocyte maturation Estrogen signaling pathway Salmonella infection Pathways in cancer Chemical carcinogenesis - receptor activation Prostate cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation vRNP Assembly Regulation of actin dynamics for phagocytic cup formation eNOS activation Regulation of PLK1 Activity at G2/M Transition Scavenging by Class F Receptors HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Sema3A PAK dependent Axon repulsion VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Uptake and function of diphtheria toxin Anchoring of the basal body to the plasma membrane Constitutive Signaling by EGFRvIII Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Downregulation of ERBB2 signaling ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-dependent gene expression Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants +56 more

Tight junction Antigen processing and presentation Lipid and atherosclerosis Regulation of HSF1-mediated heat shock response +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction Serotonin receptors G alpha (i) signalling events +3 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction Serotonin receptors G alpha (i) signalling events +3 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction Serotonergic synapse Inflammatory mediator regulation of TRP channels Serotonin receptors G alpha (q) signalling events +4 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction Serotonergic synapse Inflammatory mediator regulation of TRP channels Serotonin receptors G alpha (q) signalling events +4 more

Serotonergic synapse Taste transduction Neurotransmitter receptors and postsynaptic signal transmission

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +4 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Serotonin receptors G alpha (i) signalling events +2 more

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +4 more

Ras signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +4 more

Huntington disease Pathways of neurodegeneration - multiple diseases

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage Interleukin-9 signaling +1 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Synthesis of IP2, IP, and Ins in the cytosol +1 more

Viral life cycle - HIV-1 Notch signaling pathway Thyroid hormone signaling pathway Human T-cell leukemia virus 1 infection Viral carcinogenesis Pre-NOTCH Transcription and Translation YAP1- and WWTR1 (TAZ)-stimulated gene expression NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Physiological factors Metalloprotease DUBs RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression Regulation of FOXO transcriptional activity by acetylation +17 more

Aldosterone synthesis and secretion TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential

Glycolysis / Gluconeogenesis Cysteine and methionine metabolism Pyruvate metabolism Propanoate metabolism Metabolic pathways HIF-1 signaling pathway Glucagon signaling pathway Central carbon metabolism in cancer Pyruvate metabolism +6 more

Glycine, serine and threonine metabolism Arginine and proline metabolism Histidine metabolism Tyrosine metabolism Phenylalanine metabolism Tryptophan metabolism Drug metabolism - cytochrome P450 Metabolic pathways Serotonergic synapse Dopaminergic synapse Parkinson disease Cocaine addiction Amphetamine addiction Alcoholism Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Norepinephrine Neurotransmitter Release Cycle Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolism of serotonin Defective MAOA causes Brunner syndrome (BRUNS) Interleukin-4 and Interleukin-13 signaling +18 more

Glycine, serine and threonine metabolism Arginine and proline metabolism Histidine metabolism Tyrosine metabolism Phenylalanine metabolism Tryptophan metabolism Drug metabolism - cytochrome P450 Metabolic pathways Serotonergic synapse Dopaminergic synapse Parkinson disease Cocaine addiction Amphetamine addiction Alcoholism Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB +12 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium +3 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Antifolate resistance MAPK signaling pathway Ras signaling pathway cAMP signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Cellular senescence Osteoclast differentiation Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Neurotrophin signaling pathway Prolactin signaling pathway Adipocytokine signaling pathway Relaxin signaling pathway Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Pancreatic cancer Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection +96 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Alcoholism Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +5 more

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events

Neuroactive ligand-receptor interaction HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors PTK6 Expression +2 more

MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway NTF3 activates NTRK3 signaling Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PI3K +4 more

MAPK signaling pathway Ras signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Alcoholism Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 activates RAC1 +6 more

Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PI3K +4 more

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (q) signalling events

Calcium signaling pathway Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (q) signalling events +1 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (i) signalling events +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Oxytocin signaling pathway Vasopressin-like receptors G alpha (q) signalling events +3 more

Calcium signaling pathway Neuroactive ligand-receptor interaction NOD-like receptor signaling pathway Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection +4 more

Neuroactive ligand-receptor interaction Hormone signaling Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Cocaine addiction Amphetamine addiction Alcoholism Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events +8 more

Fructose and mannose metabolism Metabolic pathways HIF-1 signaling pathway AMPK signaling pathway Regulation of glycolysis by fructose 2,6-bisphosphate metabolism +2 more

Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Galactose metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids RNA degradation HIF-1 signaling pathway AMPK signaling pathway Thyroid hormone signaling pathway Glucagon signaling pathway Central carbon metabolism in cancer Neutrophil degranulation Glycolysis +12 more