Mood disorder

Downstream signaling of activated FGFR1

Rap1 signaling pathway Yersinia infection Generation of second messenger molecules Signal regulatory protein family interactions +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction GABAergic synapse Taste transduction Estrogen signaling pathway GnRH secretion Morphine addiction Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +9 more

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism +7 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +2 more

GnRH secretion HCN channels

HATs acetylate histones

Formation of the cornified envelope

Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Axonal growth inhibition (RHOA activation)

Cytoskeleton in muscle cells Smooth Muscle Contraction

Post-translational modification: synthesis of GPI-anchored proteins

Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation Human T-cell leukemia virus 1 infection Viral carcinogenesis Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +8 more

MAPK signaling pathway Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases Caspase-mediated cleavage of cytoskeletal proteins +2 more

Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation +2 more

Calcium signaling pathway Signaling by MST1

Motor proteins Pathogenic Escherichia coli infection

Virion - Ebolavirus, Lyssavirus and Morbillivirus Cell adhesion molecules Prion disease NCAM signaling for neurite out-growth NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling +5 more

Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation +26 more

Cell adhesion molecules Post-translational modification: synthesis of GPI-anchored proteins

MAPK signaling pathway FoxO signaling pathway Wnt signaling pathway Adherens junction Ca2+ pathway +2 more

PPAR signaling pathway Efferocytosis Insulin resistance Non-alcoholic fatty liver disease Hepatitis C PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis +12 more

Apelin signaling pathway Huntington disease PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis +1 more

Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism Metabolic pathways Nucleotide metabolism Abacavir metabolism Purine catabolism +4 more

Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation +32 more

Ether lipid metabolism Metabolic pathways Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation +13 more

ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +1 more

Purine metabolism Metabolic pathways cAMP signaling pathway Parathyroid hormone synthesis, secretion and action Morphine addiction DARPP-32 events +3 more

HDMs demethylate histones

Neuroactive ligand-receptor interaction Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +1 more

Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules

Adherens junction Chemical carcinogenesis - reactive oxygen species Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity +2 more

Virion - Ebolavirus, Lyssavirus and Morbillivirus Cell adhesion molecules Prion disease NCAM signaling for neurite out-growth NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling +5 more