Metabolic syndrome

Endocytosis

Ubiquitin mediated proteolysis Endocytosis Notch signaling pathway TNF signaling pathway Non-alcoholic fatty liver disease Downregulation of ERBB4 signaling NOD1/2 Signaling Pathway Activated NOTCH1 Transmits Signal to the Nucleus Degradation of GLI1 by the proteasome Hedgehog 'on' state RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation +10 more

Rap1 signaling pathway Cell adhesion molecules Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Leukocyte transendothelial migration Regulation of actin cytoskeleton Malaria Staphylococcus aureus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Rheumatoid arthritis Viral myocarditis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration +14 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Regulation of actin cytoskeleton Cytoskeleton in muscle cells Human papillomavirus infection Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions ECM proteoglycans +10 more

Platelet degranulation

Calcium signaling pathway cGMP-PKG signaling pathway Phosphatidylinositol signaling system Oocyte meiosis Apoptosis Cellular senescence Vascular smooth muscle contraction Apelin signaling pathway Osteoclast differentiation Gap junction Platelet activation NOD-like receptor signaling pathway C-type lectin receptor signaling pathway Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Taste transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Estrogen signaling pathway Thyroid hormone synthesis Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Shigellosis Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Proteoglycans in cancer Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +52 more

Polycomb repressive complex Signaling pathways regulating pluripotency of stem cells PRC2 methylates histones and DNA

Transcriptional misregulation in cancer Factors involved in megakaryocyte development and platelet production

ATP-dependent chromatin remodeling Spinocerebellar ataxia Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression +15 more

HATs acetylate histones

HATs acetylate histones

Voltage gated Potassium channels

Voltage gated Potassium channels Phase 3 - rapid repolarisation

Voltage gated Potassium channels

Phase 1 - inactivation of fast Na+ channels

Cholinergic synapse Oxytocin signaling pathway Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +3 more

Circadian entrainment Retrograde endocannabinoid signaling Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Estrogen signaling pathway Oxytocin signaling pathway GnRH secretion Morphine addiction Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +9 more

Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential +2 more

cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion Renin secretion Salivary secretion Pancreatic secretion Ca2+ activated K+ channels +4 more

Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion Pancreatic secretion Protein digestion and absorption Vibrio cholerae infection Voltage gated Potassium channels Phase 3 - rapid repolarisation Phase 2 - plateau phase +6 more

Cholinergic synapse Voltage gated Potassium channels

Motor proteins MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins +1 more

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Endocytosis Dopaminergic synapse Motor proteins Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Salmonella infection Non-small cell lung cancer MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins +12 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway Hematopoietic cell lineage Melanogenesis Pathways in cancer Acute myeloid leukemia Breast cancer Central carbon metabolism in cancer PIP3 activates AKT signaling Signaling by SCF-KIT Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors +15 more

Lysine degradation Metabolic pathways Cushing syndrome Transcriptional misregulation in cancer PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs +4 more

Lysine degradation Metabolic pathways PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +1 more

Negative regulation of TCF-dependent signaling by WNT ligand antagonists Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling

Mannose type O-glycan biosynthesis Metabolic pathways Defective LARGE causes MDDGA6 and MDDGB6 O-linked glycosylation +1 more

Aminoacyl-tRNA biosynthesis Mitochondrial tRNA aminoacylation

NF-kappa B signaling pathway Toll-like receptor signaling pathway Alcoholic liver disease Tuberculosis Lipid and atherosclerosis Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling +6 more

NF-kappa B signaling pathway Toll-like receptor signaling pathway Alcoholic liver disease Tuberculosis Lipid and atherosclerosis Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling +6 more