Metabolic syndrome

Taurine and hypotaurine metabolism Glutathione metabolism Metabolic pathways Glutathione synthesis and recycling Aflatoxin activation and detoxification +2 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production +3 more

Endocytosis Yersinia infection

Neuroactive ligand-receptor interaction G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production +1 more

Rho GTPase cycle

Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Sphingolipid signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Axon guidance Apelin signaling pathway Gap junction Platelet activation Leukocyte transendothelial migration Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Renin secretion Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Gastric acid secretion Parkinson disease Cocaine addiction Morphine addiction Alcoholism Pertussis Chagas disease Toxoplasmosis Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation PLC beta mediated events Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling +46 more

Phototransduction PLC beta mediated events G-protein activation Ca2+ pathway G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +3 more

Ras signaling pathway Chemokine signaling pathway Hormone signaling PI3K-Akt signaling pathway Apelin signaling pathway Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Olfactory transduction Relaxin signaling pathway Morphine addiction Alcoholism Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +44 more

Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport

Post-translational modification: synthesis of GPI-anchored proteins

Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways Synthesis of PA Activation of gene expression by SREBF (SREBP) Triglyceride biosynthesis RUNX1 regulates estrogen receptor mediated transcription Estrogen-dependent gene expression +5 more

Proteoglycans in cancer Fluid shear stress and atherosclerosis A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Signaling by ROBO receptors Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport +10 more

A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport +6 more

Post-translational modification: synthesis of GPI-anchored proteins Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport +1 more

Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Dopaminergic synapse Long-term depression Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Nicotine addiction COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules +18 more

Neuroactive ligand-receptor interaction

Neuroactive ligand-receptor interaction Long-term depression

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Spinocerebellar ataxia Prion disease Cocaine addiction Amphetamine addiction Nicotine addiction Alcoholism Assembly and cell surface presentation of NMDA receptors +8 more

Calcium signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Gap junction Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Long-term depression Taste transduction Estrogen signaling pathway Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins +13 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +3 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +2 more

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events +1 more

Basal transcription factors cGMP-PKG signaling pathway

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation +31 more

Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism Synthesis of very long-chain fatty acyl-CoAs +2 more

Antigen processing: Ubiquitination & Proteasome degradation

Endocrine resistance ErbB signaling pathway GnRH signaling pathway Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action Epithelial cell signaling in Helicobacter pylori infection Coronavirus disease - COVID-19 Proteoglycans in cancer Bladder cancer Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Uptake and function of diphtheria toxin Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +36 more

cAMP signaling pathway Hydroxycarboxylic acid-binding receptors G alpha (i) signalling events

cAMP signaling pathway Hydroxycarboxylic acid-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events +1 more

cAMP signaling pathway Hydroxycarboxylic acid-binding receptors G alpha (i) signalling events

cAMP signaling pathway Taste transduction HCN channels

Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation

Notch signaling pathway Human papillomavirus infection Pathways in cancer Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH4 Intracellular Domain Regulates Transcription +4 more

Notch signaling pathway Human papillomavirus infection Pathways in cancer Breast cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription +4 more

TGF-beta signaling pathway Transferrin endocytosis and recycling

Maturity onset diabetes of the young Transcriptional misregulation in cancer

Cellular response to hypoxia

Leukotriene receptors G alpha (q) signalling events P2Y receptors G alpha (i) signalling events +1 more