Metabolic syndrome

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF) +4 more

Base excision repair Autophagy - animal Necroptosis Neutrophil extracellular trap formation Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

AMPK signaling pathway Maturity onset diabetes of the young Nuclear Receptor transcription pathway

Maturity onset diabetes of the young Nuclear Receptor transcription pathway

African trypanosomiasis Scavenging of heme from plasma

Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS-GAG biosynthesis

Steroid hormone biosynthesis Metabolic pathways Ovarian steroidogenesis Estrogen biosynthesis +1 more

Fatty acid elongation Steroid hormone biosynthesis Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs +4 more

Regulation of HSF1-mediated heat shock response

Virion - Hepatitis viruses ECM-receptor interaction Cytoskeleton in muscle cells Hepatitis B Proteoglycans in cancer Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation +17 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction Serotonin receptors G alpha (i) signalling events +3 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Taste transduction Serotonin receptors G alpha (i) signalling events +3 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction Serotonergic synapse Inflammatory mediator regulation of TRP channels Serotonin receptors G alpha (q) signalling events +4 more

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +4 more

Huntington disease Pathways of neurodegeneration - multiple diseases

Glycosaminoglycan degradation Metabolic pathways Lysosome CS/DS degradation Hyaluronan uptake and degradation +2 more

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions

Rap1 signaling pathway TGF-beta signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Oncogene Induced Senescence NGF-stimulated transcription +3 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis Osteoclast differentiation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation Leishmaniasis Chagas disease Toxoplasmosis Tuberculosis Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Interferon gamma signaling Regulation of IFNG signaling +17 more

Hedgehog 'off' state Intraflagellar transport

Huntington disease Pathways of neurodegeneration - multiple diseases Hedgehog 'off' state Intraflagellar transport +1 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway HIF-1 signaling pathway FoxO signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal Endocytosis mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Long-term depression Ovarian steroidogenesis Progesterone-mediated oocyte maturation Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer Glioma Prostate cancer Melanoma Breast cancer Hepatocellular carcinoma Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling +31 more

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Cell adhesion molecules

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Legionellosis Yersinia infection African trypanosomiasis Malaria Tuberculosis Influenza A Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection +18 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Glycoprotein hormones +1 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of IP2, IP, and Ins in the cytosol +3 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Insulin signaling pathway Synthesis of IP2, IP, and Ins in the cytosol +2 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system B cell receptor signaling pathway Fc gamma R-mediated phagocytosis Insulin signaling pathway Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling +6 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Hormone signaling mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Adherens junction Insulin signaling pathway Ovarian steroidogenesis Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Aldosterone-regulated sodium reabsorption Alzheimer disease Diabetic cardiomyopathy PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling +26 more

RNA polymerase II transcribes snRNA genes

Phosphatidylinositol signaling system Synthesis of pyrophosphates in the cytosol

Nucleocytoplasmic transport

Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF) +4 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Gap junction Serotonergic synapse Inflammatory mediator regulation of TRP channels Serotonin receptors G alpha (q) signalling events +4 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Legionellosis Yersinia infection African trypanosomiasis Malaria Tuberculosis Influenza A Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection +18 more

EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor HIF-1 signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Intestinal immune network for IgA production Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Hypertrophic cardiomyopathy Lipid and atherosclerosis Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response +59 more

Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system B cell receptor signaling pathway Fc gamma R-mediated phagocytosis Insulin signaling pathway Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling +6 more