Lung cancer

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Telomere Extension By Telomerase Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Post-translational modification: synthesis of GPI-anchored proteins

Endocytosis Synthesis of PIPs at the plasma membrane

Tight junction Th17 cell differentiation Pathways in cancer Transcriptional misregulation in cancer Chronic myeloid leukemia Acute myeloid leukemia Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression +20 more

Calcium signaling pathway Apelin signaling pathway Circadian entrainment Long-term depression Oxytocin signaling pathway Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Stimuli-sensing channels Ion homeostasis +7 more

Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins

RAB GEFs exchange GTP for GDP on RABs

Axon guidance

Axon guidance Other semaphorin interactions

SUMO is proteolytically processed

Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria SMAC, XIAP-regulated apoptotic response +1 more

Surfactant metabolism Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) +1 more

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Bile secretion Recycling of bile acids and salts

Collecting duct acid secretion Cation-coupled Chloride cotransporters

Choline metabolism in cancer Abacavir transmembrane transport Organic cation transport

Sodium/Calcium exchangers

Gluconeogenesis Aspartate and asparagine metabolism

Mineral absorption Zinc efflux and compartmentalization by the SLC30 family

Insulin processing Zinc efflux and compartmentalization by the SLC30 family

Amino acid transport across the plasma membrane

Choline metabolism in cancer Synthesis of PC Transport of bile salts and organic acids, metal ions and amine compounds

Melanin biosynthesis

Vitamin B2 (riboflavin) metabolism

Oocyte meiosis

TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Ub-specific processing proteases +3 more

Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes

Spliceosome mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis +2 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Processing of SMDT1

MET Receptor Activation Signaling by MST1

Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants

Post-translational modification: synthesis of GPI-anchored proteins

Endocytosis Synthesis of PIPs at the plasma membrane

Axon guidance Other semaphorin interactions

SUMO is proteolytically processed

Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria SMAC, XIAP-regulated apoptotic response +1 more

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Bile secretion Recycling of bile acids and salts

Collecting duct acid secretion Cation-coupled Chloride cotransporters

Gluconeogenesis Aspartate and asparagine metabolism

Mineral absorption Zinc efflux and compartmentalization by the SLC30 family

Insulin processing Zinc efflux and compartmentalization by the SLC30 family

Amino acid transport across the plasma membrane

Choline metabolism in cancer Synthesis of PC Transport of bile salts and organic acids, metal ions and amine compounds

Melanin biosynthesis

Oocyte meiosis

TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Ub-specific processing proteases +3 more

Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes

Spliceosome mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants

Telomere Extension By Telomerase Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Post-translational modification: synthesis of GPI-anchored proteins

Endocytosis Synthesis of PIPs at the plasma membrane

Axon guidance Other semaphorin interactions

SUMO is proteolytically processed

Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria SMAC, XIAP-regulated apoptotic response +1 more

Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Bile secretion Recycling of bile acids and salts

Collecting duct acid secretion Cation-coupled Chloride cotransporters

Choline metabolism in cancer Abacavir transmembrane transport Organic cation transport

Gluconeogenesis Aspartate and asparagine metabolism

Mineral absorption Zinc efflux and compartmentalization by the SLC30 family

Insulin processing Zinc efflux and compartmentalization by the SLC30 family

Amino acid transport across the plasma membrane

Choline metabolism in cancer Synthesis of PC Transport of bile salts and organic acids, metal ions and amine compounds

Melanin biosynthesis

Oocyte meiosis

TGF-beta signaling pathway Hippo signaling pathway Signaling by BMP Downregulation of TGF-beta receptor signaling SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Ub-specific processing proteases +3 more

Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes

Spliceosome mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis +2 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Processing of SMDT1

MET Receptor Activation Signaling by MST1

Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants