Lung cancer

Virion - Flavivirus and Alphavirus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Motor proteins Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis +2 more

Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer Breast cancer RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +18 more

RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock +4 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation +26 more

Ubiquitin mediated proteolysis Glycogen synthesis Myoclonic epilepsy of Lafora

Wnt signaling pathway Hippo signaling pathway

NOD-like receptor signaling pathway The NLRP1 inflammasome

Endocrine resistance Notch signaling pathway Thyroid hormone signaling pathway Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling +11 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Peptide ligand-binding receptors G alpha (i) signalling events +2 more

Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +18 more

Synaptic vesicle cycle GABAergic synapse Vasopressin-regulated water reabsorption COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network +6 more

Post-translational modification: synthesis of GPI-anchored proteins

Notch signaling pathway

Melanin biosynthesis

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

Neuroactive ligand-receptor interaction Efferocytosis G alpha (q) signalling events P2Y receptors +1 more

Chromatin modifying enzymes

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange +3 more

Base excision repair NF-kappa B signaling pathway Apoptosis Necroptosis Diabetic cardiomyopathy POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER +9 more

Focal adhesion Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components +1 more

Transcriptional misregulation in cancer

Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer +1 more

Virion - Lassa virus and SFTS virus

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway cAMP signaling pathway Renin secretion Morphine addiction G alpha (s) signalling events +4 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Prostate cancer Melanoma Choline metabolism in cancer Signaling by PDGF +11 more

Cytoskeleton in muscle cells

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion +2 more

Polycomb repressive complex Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 +6 more

HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53 +1 more

Motor proteins Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis +2 more

Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer Breast cancer RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +18 more

RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock +4 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation +26 more

Ubiquitin mediated proteolysis Glycogen synthesis Myoclonic epilepsy of Lafora

Endocrine resistance Notch signaling pathway Thyroid hormone signaling pathway Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling +11 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Peptide ligand-binding receptors G alpha (i) signalling events +2 more

Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +18 more

Notch signaling pathway

Melanin biosynthesis

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

Neuroactive ligand-receptor interaction Efferocytosis G alpha (q) signalling events P2Y receptors +1 more

Chromatin modifying enzymes

Virion - Lassa virus and SFTS virus

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion +2 more

HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53 +1 more

Virion - Flavivirus and Alphavirus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Motor proteins Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis +2 more

Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer Breast cancer RORA activates gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) HATs acetylate histones Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +18 more

RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock +4 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cellular senescence Wnt signaling pathway Osteoclast differentiation C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Lipid and atherosclerosis Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation +26 more

Ubiquitin mediated proteolysis Glycogen synthesis Myoclonic epilepsy of Lafora

Wnt signaling pathway Hippo signaling pathway

Endocrine resistance Notch signaling pathway Thyroid hormone signaling pathway Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling +11 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Peptide ligand-binding receptors G alpha (i) signalling events +2 more

Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +18 more

Synaptic vesicle cycle GABAergic synapse Vasopressin-regulated water reabsorption COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network +6 more

Notch signaling pathway

Melanin biosynthesis

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

Neuroactive ligand-receptor interaction Efferocytosis G alpha (q) signalling events P2Y receptors +1 more

Chromatin modifying enzymes

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange +3 more

Base excision repair NF-kappa B signaling pathway Apoptosis Necroptosis Diabetic cardiomyopathy POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER +9 more

Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer +1 more

Virion - Lassa virus and SFTS virus

Cytoskeleton in muscle cells

Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion +2 more

Polycomb repressive complex Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 +6 more

HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors Stabilization of p53 +1 more