Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LUNG ADENOCARCINOMA	EFO_0000571	GPR37	Unknown	37236969	GWAS catalog	Parkinson disease Pathways of neurodegeneration - multiple diseases Peptide ligand-binding receptors +1 more
		GPX2	Unknown	34290314	GWAS catalog	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +7 more
		GREM1	Unknown	32887889	GWAS catalog	TGF-beta signaling pathway
		GRHPR	Unknown	29299148	GWAS catalog	Glycine, serine and threonine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism +2 more
		GRIK1	Unknown	34062886	GWAS catalog	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
		GRM5	Unknown	34290314	GWAS catalog	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
		H4C8	Unknown	28604730	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HCN1	Unknown	34594039	GWAS catalog	GnRH secretion HCN channels
		HHIPL1	Unknown	28604730	GWAS catalog	—
		HLA-B	Unknown	27197191 32887889	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-C	Unknown	28604730 32887889	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DMA	Unknown	32887889	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +21 more
		HLA-DMB	Unknown	28604730 32887889	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOA	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOB	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DPA1	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DPB1	Unknown	27501781	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA1	Unknown	28604730 31577861 32887889 35915169 37340002	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	27197191 32887889 33893285 34290314 34594039 37340002 40783572	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB2	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRA	Unknown	28604730 34290314 35915169	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB1	Unknown	28604730 31577861 32887889 35915169	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB5	Unknown	32887889	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HMCN1	Unknown	40341939	GWAS catalog	—
		HNF1B	Unknown	27197191 32887889 37340002	GWAS catalog	Maturity onset diabetes of the young
		HNF4G	Unknown	32887889	GWAS catalog	Maturity onset diabetes of the young Nuclear Receptor transcription pathway
		HORMAD2	Unknown	34290314	GWAS catalog	—
		HOXB13	Unknown	34290314	GWAS catalog	—
		HYKK	Unknown	18385676 18385738 18780872 19654303 32887889 37340002 39024449	GWAS catalog	Lysine degradation Metabolic pathways Lysine catabolism
		IGF2BP2	Unknown	37340002	GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IGSF21	Unknown	40341939	GWAS catalog	—
		IL1RAP	Unknown	18385676	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction Th17 cell differentiation +7 more
		IRF4	Unknown	28604730 33893285 34290314 35915169	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JADE2	Unknown	39366959	GWAS catalog	HATs acetylate histones
		JAML	Unknown	35915169	GWAS catalog	Cell adhesion molecules Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
		JAZF1	Unknown	32887889	GWAS catalog	—
		JRK	Unknown	34290314 37340002	GWAS catalog	—
		KANSL1	Unknown	32887889	GWAS catalog	HATs acetylate histones
		KATNA1	Unknown	27393504	GWAS catalog	—
		KCNH1	Unknown	27197191	GWAS catalog	Voltage gated Potassium channels
		KCNQ1	Unknown	37340002	GWAS catalog	Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion +6 more
		KCTD8	Unknown	37236969	GWAS catalog	—
		KIF20B	Unknown	37340002	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KLK15	Unknown	32887889	GWAS catalog	—
		KLK2	Unknown	32887889	GWAS catalog	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KLK3	Unknown	32887889	GWAS catalog	Pathways in cancer Prostate cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
		KRT5	Unknown	34290314	GWAS catalog	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
		KRT8	Unknown	27197191	GWAS catalog	Keratinization Formation of the cornified envelope
		LAMA1	Unknown	34290314	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +12 more
		LCTL	Unknown	34290314	GWAS catalog	—
LUNG CANCER	MONDO_0008903	GPX2	Unknown	34290314	GWAS catalog	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +7 more
		GRHPR	Unknown	29299148	GWAS catalog	Glycine, serine and threonine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism +2 more
		GRIK1	Unknown	34062886	GWAS catalog	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
		GRM5	Unknown	34290314	GWAS catalog	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
		H4C8	Unknown	28604730	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HCN1	Unknown	34594039	GWAS catalog	GnRH secretion HCN channels
		HLA-B	Unknown	27197191	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-C	Unknown	28604730	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DMB	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOA	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOB	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DPA1	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA1	Unknown	28604730 31577861 35915169 37340002	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	27197191 33893285 34290314 34594039 37340002 40783572	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB2	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRA	Unknown	28604730 34290314	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB1	Unknown	31577861 35915169	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HMCN1	Unknown	40341939	GWAS catalog	—
		HNF1B	Unknown	27197191 37340002	GWAS catalog	Maturity onset diabetes of the young
		HORMAD2	Unknown	34290314	GWAS catalog	—
		HOXB13	Unknown	34290314	GWAS catalog	—
		HYKK	Unknown	18385676 18385738 18780872 19654303 32887889 37340002 39024449	GWAS catalog	Lysine degradation Metabolic pathways Lysine catabolism
		IGF2BP2	Unknown	37340002	GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IGSF21	Unknown	40341939	GWAS catalog	—
		IL1RAP	Unknown	18385676	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction Th17 cell differentiation +7 more
		IRF4	Unknown	33893285 34290314 35915169	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JADE2	Unknown	39366959	GWAS catalog	HATs acetylate histones
		JAML	Unknown	35915169	GWAS catalog	Cell adhesion molecules Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
		JRK	Unknown	34290314 37340002	GWAS catalog	—
		KATNA1	Unknown	27393504	GWAS catalog	—
		KCNH1	Unknown	27197191	GWAS catalog	Voltage gated Potassium channels
		KCNQ1	Unknown	37340002	GWAS catalog	Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion +6 more
		KIF20B	Unknown	37340002	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KRT5	Unknown	34290314	GWAS catalog	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
		LCTL	Unknown	34290314	GWAS catalog	—
LUNG CARCINOMA	EFO_0001071	GPX2	Unknown	34290314	GWAS catalog	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +7 more
		GREM1	Unknown	32887889	GWAS catalog	TGF-beta signaling pathway
		GRHPR	Unknown	29299148	GWAS catalog	Glycine, serine and threonine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism +2 more
		GRIK1	Unknown	34062886 40829600	GWAS catalog	Neuroactive ligand-receptor interaction Glutamatergic synapse Activation of Na-permeable kainate receptors +1 more
		GRM5	Unknown	34290314	GWAS catalog	Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction +10 more
		H4C8	Unknown	28604730	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +33 more
		HCN1	Unknown	34594039	GWAS catalog	GnRH secretion HCN channels
		HLA-B	Unknown	27197191 28604730 32887889	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-C	Unknown	28604730 32887889	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DMA	Unknown	32887889	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +21 more
		HLA-DMB	Unknown	28604730 32887889	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOA	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DOB	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +22 more
		HLA-DPA1	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA1	Unknown	28604730 31577861 32887889 35915169 37340002	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	27197191 28604730 32887889 33893285 34290314 34594039 37340002 37601966 37846649 40783572	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB2	Unknown	28604730	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRA	Unknown	28604730 34290314	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB1	Unknown	31577861 32887889 35915169	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DRB5	Unknown	32887889	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HMCN1	Unknown	40341939	GWAS catalog	—
		HNF1B	Unknown	27197191 32887889 37340002	GWAS catalog	Maturity onset diabetes of the young
		HNF4G	Unknown	32887889	GWAS catalog	Maturity onset diabetes of the young Nuclear Receptor transcription pathway
		HORMAD2	Unknown	34290314	GWAS catalog	—
		HOXB13	Unknown	34290314	GWAS catalog	—
		HYKK	Unknown	18385676 18385738 18780872 19654303 32887889 37340002 39024449	GWAS catalog	Lysine degradation Metabolic pathways Lysine catabolism
		IGF2BP2	Unknown	37340002	GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IGSF21	Unknown	40341939	GWAS catalog	—
		IL1RAP	Unknown	18385676	GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction Th17 cell differentiation +7 more
		IRF4	Unknown	28604730 33893285 34290314 35915169	GWAS catalog	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JADE2	Unknown	39366959	GWAS catalog	HATs acetylate histones
		JAML	Unknown	35915169	GWAS catalog	Cell adhesion molecules Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
		JAZF1	Unknown	32887889	GWAS catalog	—
		JRK	Unknown	34290314 37340002	GWAS catalog	—
		KANSL1	Unknown	32887889	GWAS catalog	HATs acetylate histones
		KATNA1	Unknown	27393504	GWAS catalog	—
		KCNH1	Unknown	27197191	GWAS catalog	Voltage gated Potassium channels
		KCNQ1	Unknown	37340002	GWAS catalog	Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion +6 more
		KIF20B	Unknown	37340002	GWAS catalog	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KLK15	Unknown	32887889	GWAS catalog	—
		KLK2	Unknown	32887889	GWAS catalog	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KLK3	Unknown	32887889	GWAS catalog	Pathways in cancer Prostate cancer Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
		KRT5	Unknown	34290314	GWAS catalog	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
		KRT8	Unknown	27197191	GWAS catalog	Keratinization Formation of the cornified envelope
		LAMA1	Unknown	34290314	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +12 more
		LCTL	Unknown	34290314	GWAS catalog	—

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