Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LUNG ADENOCARCINOMA	EFO_0000571	SPRY4	Unknown	40341939	GWAS catalog	—
		SSC5D	Unknown	28604730	GWAS catalog	—
		STAMBPL1	Unknown	19654303	GWAS catalog	Metalloprotease DUBs
		STEAP1B	Unknown	28604730	GWAS catalog	—
		STIM2	Unknown	29924316	GWAS catalog	Calcium signaling pathway
		STING1	Unknown	37167549	GWAS catalog	NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway +10 more
		STMN3	Unknown	32887889 34290314	GWAS catalog	—
		STN1	Unknown	28604730 32887889 34290314 35915169 37340002 39366959	GWAS catalog	Telomere C-strand synthesis initiation
		SVIP	Unknown	40341939	GWAS catalog	Protein processing in endoplasmic reticulum Neutrophil degranulation
		SYNE1	Unknown	40341939	GWAS catalog	Cytoskeleton in muscle cells
		SYNGR2	Unknown	26732429	GWAS catalog	—
		TAB2	Unknown	29299148	GWAS catalog	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +33 more
		TASP1	Unknown	29924316	GWAS catalog	—
		TBC1D5	Unknown	29924316	GWAS catalog	—
		TEKT5	Unknown	28604730	GWAS catalog	—
		TENM2	Unknown	32887889 34981446	GWAS catalog	—
		TERT	Unknown	19836008 20700438 20871597 21725308 22797724 23143601 27197191 27393504 27501781 28604730 31326317 31577861 32887889 32889700 34290314 34594039 35915169 37167549 37340002 38970920 39366959 40341939 40783572	GWAS catalog	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TESPA1	Unknown	29299148	GWAS catalog	—
		TET2	Unknown	27197191	GWAS catalog	—
		TET3	Unknown	37167549	GWAS catalog	—
		TEX29	Unknown	33893285	GWAS catalog	—
		TEX51	Unknown	29924316	GWAS catalog	—
		TFPI	Unknown	28604730	GWAS catalog	Complement and coagulation cascades Extrinsic Pathway of Fibrin Clot Formation
		TGIF2-RAB5IF	Unknown	32887889	GWAS catalog	—
		TGM3	Unknown	34290314 37340002	GWAS catalog	—
		TGM5	Unknown	19654303	GWAS catalog	Formation of the cornified envelope
		THADA	Unknown	32887889	GWAS catalog	tRNA modification in the nucleus and cytosol
		TLDC2	Unknown	29924316	GWAS catalog	—
		TLE3	Unknown	28604730	GWAS catalog	Wnt signaling pathway Notch signaling pathway Formation of the beta-catenin:TCF transactivating complex +3 more
		TMEM18	Unknown	36929942	GWAS catalog	—
		TMEM218	Unknown	29924316	GWAS catalog	—
		TMEM237	Unknown	28604730	GWAS catalog	—
		TMEM250	Unknown	29924316	GWAS catalog	—
		TMX1	Unknown	29299148	GWAS catalog	—
		TNFAIP6	Unknown	23143601	GWAS catalog	Neutrophil degranulation
		TNFRSF19	Unknown	21725308	GWAS catalog	Cytokine-cytokine receptor interaction
		TNXB	Unknown	28604730	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		TOX3	Unknown	32887889 37340002	GWAS catalog	—
		TP53BP1	Unknown	39366959	GWAS catalog	NOD-like receptor signaling pathway SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		TP63	Unknown	20871597 21725308 22797724 23143601 24880342 27501781 28604730 31326317 32889700 34594039 35915169 37340002 39366959 40783572	GWAS catalog	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TP73	Unknown	34290314	GWAS catalog	p53 signaling pathway Hippo signaling pathway Neurotrophin signaling pathway +8 more
		TPRG1	Unknown	31326317 32889700 34594039 35915169 37340002 40783572	GWAS catalog	—
		TRAK2	Unknown	34290314	GWAS catalog	GABAergic synapse
		TRIM21	Unknown	28604730	GWAS catalog	Systemic lupus erythematosus STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA +2 more
		TRIM26	Unknown	28604730	GWAS catalog	Interferon gamma signaling
		TRIM35	Unknown	28604730	GWAS catalog	Interferon gamma signaling
		TRIM46	Unknown	37340002	GWAS catalog	Interferon gamma signaling
		TRMT9B	Unknown	28604730	GWAS catalog	tRNA modification in the nucleus and cytosol
		TRPC4AP	Unknown	34290314	GWAS catalog	TRP channels
		TSBP1	Unknown	37167549	GWAS catalog	—
LUNG CANCER	MONDO_0008903	SPRY4	Unknown	40341939	GWAS catalog	—
		STAMBPL1	Unknown	19654303	GWAS catalog	Metalloprotease DUBs
		STEAP1B	Unknown	28604730	GWAS catalog	—
		STING1	Unknown	37167549	GWAS catalog	NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway +10 more
		STMN3	Unknown	34290314	GWAS catalog	—
		STN1	Unknown	28604730 34290314 37340002	GWAS catalog	Telomere C-strand synthesis initiation
		SYNGR2	Unknown	26732429	GWAS catalog	—
		TAB2	Unknown	29299148	GWAS catalog	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +33 more
		TENM2	Unknown	34981446	GWAS catalog	—
		TERT	Unknown	21725308 23143601 27393504 31577861 34290314 34594039 35915169 36819030 37167549 37340002 38970920 39024449 39366959 40341939 40465716 40783572	GWAS catalog	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TESPA1	Unknown	29299148	GWAS catalog	—
		TET3	Unknown	37167549	GWAS catalog	—
		TEX29	Unknown	33893285	GWAS catalog	—
		TGM3	Unknown	34290314 37340002	GWAS catalog	—
		TGM5	Unknown	19654303	GWAS catalog	Formation of the cornified envelope
		TMEM237	Unknown	28604730	GWAS catalog	—
		TMX1	Unknown	29299148	GWAS catalog	—
		TNFAIP6	Unknown	23143601	GWAS catalog	Neutrophil degranulation
		TNFRSF19	Unknown	21725308	GWAS catalog	Cytokine-cytokine receptor interaction
		TNXB	Unknown	28604730	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		TOX3	Unknown	37340002	GWAS catalog	—
		TP53BP1	Unknown	39366959	GWAS catalog	NOD-like receptor signaling pathway SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		TP63	Unknown	21725308 23143601 24880342 28604730 34594039 35915169 37340002 40783572	GWAS catalog	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TP73	Unknown	34290314	GWAS catalog	p53 signaling pathway Hippo signaling pathway Neurotrophin signaling pathway +8 more
		TPRG1	Unknown	34594039 35915169 37340002 40783572	GWAS catalog	—
		TRAK2	Unknown	34290314	GWAS catalog	GABAergic synapse
		TRIM21	Unknown	28604730	GWAS catalog	Systemic lupus erythematosus STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA +2 more
		TRIM26	Unknown	28604730	GWAS catalog	Interferon gamma signaling
		TRIM35	Unknown	28604730	GWAS catalog	Interferon gamma signaling
		TRIM46	Unknown	36819030 37340002	GWAS catalog	Interferon gamma signaling
		TRPC4AP	Unknown	34290314	GWAS catalog	TRP channels
		TSBP1	Unknown	37167549	GWAS catalog	—
LUNG CARCINOMA	EFO_0001071	SPRY4	Unknown	40341939	GWAS catalog	—
		STAMBPL1	Unknown	19654303	GWAS catalog	Metalloprotease DUBs
		STEAP1B	Unknown	28604730	GWAS catalog	—
		STING1	Unknown	37167549	GWAS catalog	NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway +10 more
		STMN3	Unknown	32887889 34290314	GWAS catalog	—
		STN1	Unknown	28604730 32887889 34290314 37340002	GWAS catalog	Telomere C-strand synthesis initiation
		SYNGR2	Unknown	26732429	GWAS catalog	—
		TAB2	Unknown	29299148	GWAS catalog	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +33 more
		TENM2	Unknown	32887889 34981446	GWAS catalog	—
		TERT	Unknown	21725308 23143601 27197191 27393504 28604730 31577861 32887889 34290314 34594039 35915169 37167549 37340002 37846649 38970920 40341939 40783572	GWAS catalog	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TESPA1	Unknown	29299148	GWAS catalog	—
		TET2	Unknown	27197191	GWAS catalog	—
		TET3	Unknown	37167549	GWAS catalog	—
		TEX29	Unknown	33893285	GWAS catalog	—
		TGIF2-RAB5IF	Unknown	32887889	GWAS catalog	—
		TGM3	Unknown	34290314 37340002	GWAS catalog	—
		TGM5	Unknown	19654303	GWAS catalog	Formation of the cornified envelope
		THADA	Unknown	32887889	GWAS catalog	tRNA modification in the nucleus and cytosol
		TMEM18	Unknown	36929942	GWAS catalog	—
		TMEM237	Unknown	28604730	GWAS catalog	—
		TMX1	Unknown	29299148	GWAS catalog	—
		TNFAIP6	Unknown	23143601	GWAS catalog	Neutrophil degranulation
		TNFRSF19	Unknown	21725308	GWAS catalog	Cytokine-cytokine receptor interaction
		TNXB	Unknown	28604730	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		TOX3	Unknown	32887889 37340002	GWAS catalog	—
		TP53BP1	Unknown	28604730 39366959	GWAS catalog	NOD-like receptor signaling pathway SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		TP63	Unknown	21725308 23143601 24880342 28604730 31009812 34594039 35915169 37340002 37846649 40783572	GWAS catalog	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TP73	Unknown	34290314	GWAS catalog	p53 signaling pathway Hippo signaling pathway Neurotrophin signaling pathway +8 more
		TPRG1	Unknown	34594039 35915169 37340002 40783572	GWAS catalog	—
		TRAK2	Unknown	34290314	GWAS catalog	GABAergic synapse
		TRIM21	Unknown	28604730	GWAS catalog	Systemic lupus erythematosus STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA +2 more
		TRIM26	Unknown	28604730	GWAS catalog	Interferon gamma signaling
		TRIM35	Unknown	28604730	GWAS catalog	Interferon gamma signaling
		TRIM46	Unknown	37340002	GWAS catalog	Interferon gamma signaling
		TRPC4AP	Unknown	34290314	GWAS catalog	TRP channels
		TSBP1	Unknown	37167549	GWAS catalog	—

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