Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LUNG ADENOCARCINOMA	EFO_0000571	TTC33	Unknown	37340002	GWAS catalog	—
		TTC7A	Unknown	40341939	GWAS catalog	—
		TUB	Unknown	29924316	GWAS catalog	—
		TUBA1C	Unknown	27197191	GWAS catalog	Phagosome Apoptosis Tight junction +33 more
		TYR	Unknown	32887889 33893285 34290314	GWAS catalog	Tyrosine metabolism Metabolic pathways Melanogenesis +1 more
		UBAC1	Unknown	32699080	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		UBE4A	Unknown	28604730	GWAS catalog	Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation
		UBTD2	Unknown	34290314	GWAS catalog	—
		UBXN4	Unknown	32889700	GWAS catalog	Protein processing in endoplasmic reticulum
		USHBP1	Unknown	27197191	GWAS catalog	—
		VPS13B	Unknown	40341939	GWAS catalog	—
		VTI1A	Unknown	23143601 31326317 32889700 34594039 35915169 37340002 40783572	GWAS catalog	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		VWF	Unknown	40341939	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		WDR76	Unknown	28604730	GWAS catalog	—
		WNK1	Unknown	28604730 39366959	GWAS catalog	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WSCD1	Unknown	40341939	GWAS catalog	—
		WSCD2	Unknown	40341939	GWAS catalog	—
		XCL2	Unknown	28604730 39366959	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		ZBTB38	Unknown	32887889	GWAS catalog	—
		ZBTB46	Unknown	32887889	GWAS catalog	—
		ZBTB9	Unknown	28604730	GWAS catalog	—
		ZCWPW2	Unknown	32887889	GWAS catalog	—
		ZFAT	Unknown	34290314	GWAS catalog	—
		ZNF184	Unknown	28604730	GWAS catalog	Generic Transcription Pathway
		ZNF276	Unknown	33893285	GWAS catalog	—
		ZNF322	Unknown	28604730	GWAS catalog	—
		ZRANB1	Unknown	34062886	GWAS catalog	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
		ZSCAN23	Unknown	28604730	GWAS catalog	—
		ZZZ3	Unknown	28604730	GWAS catalog	—
LUNG CANCER	MONDO_0008903 MONDO:0008903 211980	ABHD8	Unknown	36819030	GWAS catalog	—
		CA10	Unknown	35138370	GWAS catalog	—
		CDKN2B	Unknown	36819030	GWAS catalog	FoxO signaling pathway Cell cycle Cellular senescence +12 more
		CMTR2	Unknown	—	GenCC	—
		ERBB2	Unknown	12460919 16533793 15118125 22696596 9751628 15457249 16672372	ClinVar, GenCC, HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERCC6	Unknown	—	ClinVar	Nucleotide excision repair B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex +4 more
		GSPT1	Unknown	35138370	GWAS catalog	mRNA surveillance pathway Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) +1 more
		HSPA4	Unknown	36819030	GWAS catalog	Tight junction Antigen processing and presentation Lipid and atherosclerosis +1 more
		IRF1	Unknown	—	ClinVar, HPO	C-type lectin receptor signaling pathway TNF signaling pathway Prolactin signaling pathway +5 more
		LPIN2	Unknown	39024449	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +6 more
		MACROD2	Unknown	35138370	GWAS catalog	—
		MAP3K8	Unknown	—	ClinVar, HPO	MAPK signaling pathway Toll-like receptor signaling pathway T cell receptor signaling pathway +3 more
		MMS22L	Unknown	39366959	GWAS catalog	—
		NAV1	Unknown	40155373	GWAS catalog	—
		P3R3URF-PIK3R3	Unknown	36819030	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +101 more
		PIK3CA	Unknown	—	ClinVar, HPO	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PLCL1	Unknown	40155373	GWAS catalog	GABAergic synapse
		PLEKHG6	Unknown	40155373	GWAS catalog	—
		POM121L2	Unknown	36819030	GWAS catalog	Nucleocytoplasmic transport Amyotrophic lateral sclerosis
		PPP2R1B	Unknown	—	ClinVar, HPO	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +42 more
		PTPRA	Unknown	40155373	GWAS catalog	NCAM signaling for neurite out-growth RAF/MAP kinase cascade
		TTC33	Unknown	37340002	GWAS catalog	—
		TTC7A	Unknown	40341939	GWAS catalog	—
		TYR	Unknown	33893285 34290314	GWAS catalog	Tyrosine metabolism Metabolic pathways Melanogenesis +1 more
		UBTD2	Unknown	34290314	GWAS catalog	—
		USHBP1	Unknown	27197191	GWAS catalog	—
		VTI1A	Unknown	23143601 34594039 35915169 37340002 40783572	GWAS catalog	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		VWF	Unknown	40341939	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		WDR76	Unknown	28604730	GWAS catalog	—
		WNK1	Unknown	28604730 39366959 40155373	GWAS catalog	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WSCD2	Unknown	40341939	GWAS catalog	—
		XCL2	Unknown	28604730 39366959	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		ZBTB9	Unknown	28604730	GWAS catalog	—
		ZFAT	Unknown	34290314	GWAS catalog	—
		ZNF184	Unknown	28604730	GWAS catalog	Generic Transcription Pathway
		ZNF276	Unknown	33893285	GWAS catalog	—
		ZNF322	Unknown	28604730	GWAS catalog	—
		ZRANB1	Unknown	34062886	GWAS catalog	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
		ZSCAN23	Unknown	28604730	GWAS catalog	—
		ZZZ3	Unknown	28604730	GWAS catalog	—
LUNG CARCINOMA	EFO_0001071	TTC33	Unknown	37340002	GWAS catalog	—
		TTC7A	Unknown	40341939	GWAS catalog	—
		TUB	Unknown	29924316	GWAS catalog	—
		TUBA1C	Unknown	27197191	GWAS catalog	Phagosome Apoptosis Tight junction +33 more
		TYR	Unknown	32887889 33893285 34290314	GWAS catalog	Tyrosine metabolism Metabolic pathways Melanogenesis +1 more
		UBTD2	Unknown	34290314	GWAS catalog	—
		USHBP1	Unknown	27197191	GWAS catalog	—
		VPS13B	Unknown	40341939	GWAS catalog	—
		VTI1A	Unknown	23143601 34594039 35915169 37340002 37846649 40783572	GWAS catalog	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		VWF	Unknown	40341939	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		WDR76	Unknown	28604730	GWAS catalog	—
		WNK1	Unknown	28604730 39366959	GWAS catalog	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WSCD2	Unknown	40341939	GWAS catalog	—
		XCL2	Unknown	28604730 39366959	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		ZBTB38	Unknown	32887889	GWAS catalog	—
		ZBTB46	Unknown	32887889	GWAS catalog	—
		ZBTB9	Unknown	28604730	GWAS catalog	—
		ZCWPW2	Unknown	32887889	GWAS catalog	—
		ZFAT	Unknown	34290314	GWAS catalog	—
		ZNF184	Unknown	28604730	GWAS catalog	Generic Transcription Pathway
		ZNF276	Unknown	33893285	GWAS catalog	—
		ZNF322	Unknown	28604730	GWAS catalog	—
		ZRANB1	Unknown	34062886	GWAS catalog	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
		ZSCAN23	Unknown	28604730	GWAS catalog	—
		ZZZ3	Unknown	28604730	GWAS catalog	—

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Lung cancer

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