Intellectual developmental disorder

Efferocytosis Platelet activation ADP signalling through P2Y purinoceptor 12 P2Y receptors G alpha (i) signalling events +2 more

mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +5 more

Base excision repair NF-kappa B signaling pathway Apoptosis Necroptosis Diabetic cardiomyopathy POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER +9 more

Signaling pathways regulating pluripotency of stem cells Maturity onset diabetes of the young Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) +1 more

Metabolic pathways Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism +2 more

Protein processing in endoplasmic reticulum Antigen processing and presentation Human cytomegalovirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection ER-Phagosome pathway Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC +6 more

Peroxisome Alpha-oxidation of phytanate Peroxisomal protein import

Peroxisome Peroxisomal protein import

Peroxisome Peroxisomal protein import

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Synthesis of glycosylphosphatidylinositol (GPI)

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways

RNA polymerase Nucleotide excision repair Cytosolic DNA-sensing pathway Huntington disease Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Viral Messenger RNA Synthesis Cytosolic sensors of pathogen-associated DNA MicroRNA (miRNA) biogenesis B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Pol II CTD phosphorylation and interaction with CE Estrogen-dependent gene expression +34 more

RNA polymerase Cytosolic DNA-sensing pathway Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter +3 more

Mannose type O-glycan biosynthesis Metabolic pathways Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation +1 more

Other types of O-glycan biosynthesis Mannose type O-glycan biosynthesis Metabolic pathways Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation +3 more

Fatty acid elongation Metabolic pathways Fatty acid metabolism Lysosome Fatty acyl-CoA biosynthesis +2 more

Wnt signaling pathway Asymmetric localization of PCP proteins

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Wnt signaling pathway VEGF signaling pathway Focal adhesion Gap junction Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Morphine addiction African trypanosomiasis Amoebiasis Hepatitis B Human cytomegalovirus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer Diabetic cardiomyopathy Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+ +64 more

MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis

cAMP signaling pathway Hedgehog signaling pathway Axon guidance Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Hedgehog 'off' state Ligand-receptor interactions Hedgehog 'on' state Activation of SMO +7 more

Spinocerebellar ataxia Golgi Associated Vesicle Biogenesis

Autophagy - animal Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs +2 more

Salmonella infection Measles Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs +3 more

Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway Pathways in cancer Colorectal cancer Pancreatic cancer Choline metabolism in cancer p38MAPK events +5 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Spinocerebellar ataxia Human papillomavirus infection Reelin signalling pathway +3 more

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Cellular senescence Thermogenesis Insulin signaling pathway Thyroid hormone signaling pathway Human cytomegalovirus infection Human papillomavirus infection Herpes simplex virus 1 infection Choline metabolism in cancer Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1 +18 more

Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs +3 more

Autophagy - animal

Steroid biosynthesis Metabolic pathways Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol +2 more

SDK interactions

Protein processing in endoplasmic reticulum Pathogenic Escherichia coli infection COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC +3 more

Axon guidance Other semaphorin interactions Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins +1 more

Salivary secretion Pancreatic secretion Vibrio cholerae infection Cation-coupled Chloride cotransporters +1 more

Urea cycle

Calcium signaling pathway cGMP-PKG signaling pathway Necroptosis Cellular senescence Neutrophil extracellular trap formation Alzheimer disease Parkinson disease Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Influenza A Human T-cell leukemia virus 1 infection Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane +14 more

Platinum drug resistance Mineral absorption Metal ion SLC transporters

Base excision repair NF-kappa B signaling pathway Apoptosis Necroptosis Diabetic cardiomyopathy POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER +9 more

Signaling pathways regulating pluripotency of stem cells Maturity onset diabetes of the young Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) +1 more

Metabolic pathways Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism +2 more

Peroxisome Alpha-oxidation of phytanate Peroxisomal protein import

Peroxisome Peroxisomal protein import

RNA polymerase Cytosolic DNA-sensing pathway Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter +3 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Wnt signaling pathway VEGF signaling pathway Focal adhesion Gap junction Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Morphine addiction African trypanosomiasis Amoebiasis Hepatitis B Human cytomegalovirus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer Diabetic cardiomyopathy Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+ +64 more

MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis

Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway Pathways in cancer Colorectal cancer Pancreatic cancer Choline metabolism in cancer p38MAPK events +5 more

G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Steroid biosynthesis Metabolic pathways Activation of gene expression by SREBF (SREBP) Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol +2 more

Platinum drug resistance Mineral absorption Metal ion SLC transporters