Intellectual developmental disorder

Ubiquitin mediated proteolysis Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation

Ubiquitin mediated proteolysis Parkinson disease Pathways of neurodegeneration - multiple diseases ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation +5 more

Protein processing in endoplasmic reticulum Amyotrophic lateral sclerosis Cargo recognition for clathrin-mediated endocytosis

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

Histidine metabolism Metabolic pathways Histidine catabolism

Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation

Mitophagy - animal Protein processing in endoplasmic reticulum Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Legionellosis Translesion Synthesis by POLH HSF1 activation ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Defective CFTR causes cystic fibrosis Josephin domain DUBs Ovarian tumor domain proteases Neutrophil degranulation E3 ubiquitin ligases ubiquitinate target proteins Protein methylation +14 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production +3 more

Spinocerebellar ataxia Lipid and atherosclerosis Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance +2 more

Endocytosis WNT ligand biogenesis and trafficking

Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis Necroptosis Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III +5 more

Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation

Hedgehog 'off' state Intraflagellar transport

Autophagy - animal Macroautophagy

Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors

Cell cycle Oocyte meiosis PI3K-Akt signaling pathway Hippo signaling pathway Hepatitis C Viral carcinogenesis Activation of BAD and translocation to mitochondria Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors +15 more

Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription

Generic Transcription Pathway

Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease

Generic Transcription Pathway

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Polycomb repressive complex

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Taste transduction Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +34 more

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more

Hippo signaling pathway Tight junction Human papillomavirus infection Unblocking of NMDA receptors, glutamate binding and activation Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules +5 more

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock B-WICH complex positively regulates rRNA expression CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation +66 more

Lysine degradation Metabolic pathways Cushing syndrome Transcriptional misregulation in cancer PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs +4 more

MAPK signaling pathway cGMP-PKG signaling pathway Apelin signaling pathway Oxytocin signaling pathway Parathyroid hormone synthesis, secretion and action Transcriptional misregulation in cancer Fluid shear stress and atherosclerosis Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis +7 more

SUMOylation of chromatin organization proteins

HIF-1 signaling pathway Efferocytosis Insulin secretion Thyroid hormone signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Bile secretion Human T-cell leukemia virus 1 infection Pathways in cancer Renal cell carcinoma Central carbon metabolism in cancer Diabetic cardiomyopathy Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis +15 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination +6 more

mTOR signaling pathway AMPK signaling pathway Energy dependent regulation of mTOR by LKB1-AMPK

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

MAPK signaling pathway cGMP-PKG signaling pathway Apelin signaling pathway Oxytocin signaling pathway Parathyroid hormone synthesis, secretion and action Transcriptional misregulation in cancer Fluid shear stress and atherosclerosis Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis +7 more

HIF-1 signaling pathway Efferocytosis Insulin secretion Thyroid hormone signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Bile secretion Human T-cell leukemia virus 1 infection Pathways in cancer Renal cell carcinoma Central carbon metabolism in cancer Diabetic cardiomyopathy Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis +15 more

Histidine metabolism Metabolic pathways Histidine catabolism

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production +3 more

Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation

Autophagy - animal Macroautophagy

Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease