Intellectual developmental disorder

Protein digestion and absorption Amino acid transport across the plasma membrane Defective SLC3A1 causes cystinuria (CSNU) Defective SLC7A9 causes cystinuria (CSNU) +1 more

Antifolate resistance Vitamin digestion and absorption Mineral absorption Folate transport and metabolism Metabolism of folate and pterines Iron uptake and transport +3 more

Bicarbonate transporters

ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +3 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known +2 more

Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases

Apoptosis Cytoskeleton in muscle cells Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport +5 more

Cytoskeleton in muscle cells NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport +2 more

ATP-dependent chromatin remodeling

Steroid hormone biosynthesis N-Glycan biosynthesis Metabolic pathways Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ +3 more

Axon guidance Rho GTPase cycle RHO GTPases Activate Formins

Axon guidance Rho GTPase cycle

Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)

TP53 Regulates Metabolic Genes Respiratory electron transport

Cytoskeleton in muscle cells

Amino acids regulate mTORC1

Basal transcription factors RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance +4 more

Basal transcription factors Ub-specific processing proteases RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance +5 more

TBC/RABGAPs

Wnt signaling pathway Hippo signaling pathway Adherens junction Melanogenesis Cushing syndrome Alcoholic liver disease Salmonella infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Acute myeloid leukemia Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes TCF7L2 mutants don't bind CTBP Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling +26 more

Tyrosine metabolism Folate biosynthesis Metabolic pathways Dopaminergic synapse Prolactin signaling pathway Parkinson disease Cocaine addiction Amphetamine addiction Alcoholism Catecholamine biosynthesis +7 more

Nucleocytoplasmic transport Spliceosome Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination +2 more

Anchoring of the basal body to the plasma membrane

Lysine degradation Metabolic pathways Carnitine synthesis

Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +12 more

Lysosome XBP1(S) activates chaperone genes

COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs

tRNA modification in the nucleus and cytosol

Axon guidance GnRH secretion TRP channels

tRNA processing in the nucleus

tRNA processing in the nucleus

Transcriptional misregulation in cancer Trafficking of GluR2-containing AMPA receptors

Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Pregnenolone biosynthesis Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle +3 more

Bicarbonate transporters

Steroid hormone biosynthesis N-Glycan biosynthesis Metabolic pathways Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ +3 more

Axon guidance Rho GTPase cycle

Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)

TP53 Regulates Metabolic Genes Respiratory electron transport

Basal transcription factors RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance +4 more

Tyrosine metabolism Folate biosynthesis Metabolic pathways Dopaminergic synapse Prolactin signaling pathway Parkinson disease Cocaine addiction Amphetamine addiction Alcoholism Catecholamine biosynthesis +7 more

tRNA modification in the nucleus and cytosol

tRNA processing in the nucleus

tRNA processing in the nucleus