Intellectual developmental disorder

Major pathway of rRNA processing in the nucleolus and cytosol

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Striated Muscle Contraction +3 more

Motor proteins Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases +1 more

Synthesis of diphthamide-EEF2

DSCAM interactions

DSCAM interactions

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Hedgehog 'off' state Intraflagellar transport +3 more

Purine metabolism Pyrimidine metabolism Metabolic pathways Nucleotide metabolism Epstein-Barr virus infection Phosphate bond hydrolysis by NTPDase proteins Purinergic signaling in leishmaniasis infection +4 more

ABC-family proteins mediated transport Signaling by FGFR1 in disease Defective CFTR causes cystic fibrosis Signaling by plasma membrane FGFR1 fusions +1 more

Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes

Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism AMPK signaling pathway Insulin signaling pathway Alcoholic liver disease ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +8 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Endocytosis PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Pathways in cancer Prostate cancer Gastric cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling FGFR2c ligand binding and activation FGFR2b ligand binding and activation Signaling by FGFR2 amplification mutants Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 fusions +26 more

MAPK signaling pathway Focal adhesion Salmonella infection Proteoglycans in cancer Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response +6 more

Antifolate resistance Endocytosis Folate transport and metabolism COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport +3 more

Ras signaling pathway FoxO signaling pathway Shigellosis AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer Ub-specific processing proteases Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes +7 more

Histidine metabolism One carbon pool by folate Metabolic pathways Histidine catabolism +1 more

Sphingolipid metabolism Metabolic pathways Lysosome Glycosphingolipid metabolism +1 more

Other glycan degradation Sphingolipid metabolism Metabolic pathways Glycosphingolipid metabolism +1 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation +1 more

Gap junction assembly

Hedgehog signaling pathway Hippo signaling pathway Pathways in cancer Basal cell carcinoma Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription +4 more

Fructose and mannose metabolism Biosynthesis of various nucleotide sugars Metabolic pathways Biosynthesis of nucleotide sugars GDP-fucose biosynthesis +2 more

Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport +9 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors GABAergic synapse Molybdenum cofactor biosynthesis +2 more

Arginine biosynthesis Alanine, aspartate and glutamate metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Alanine metabolism +4 more

Trafficking of GluR2-containing AMPA receptors

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +2 more

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway Cell cycle mTOR signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Hedgehog signaling pathway Axon guidance Hippo signaling pathway Focal adhesion Signaling pathways regulating pluripotency of stem cells IL-17 signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Neurotrophin signaling pathway Dopaminergic synapse Insulin signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Insulin resistance Non-alcoholic fatty liver disease Cushing syndrome Growth hormone synthesis, secretion and action Alcoholic liver disease Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Shigellosis Yersinia infection Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Colorectal cancer Endometrial cancer Prostate cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Lipid and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer +59 more

mRNA surveillance pathway Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +1 more

Platelet degranulation

Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +12 more

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation +33 more

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation +33 more

Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation

Polycomb repressive complex Cobalamin transport and metabolism Herpes simplex virus 1 infection Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases +3 more

GnRH secretion HCN channels

Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis MicroRNAs in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX3 regulates p14-ARF +8 more

Antigen processing: Ubiquitination & Proteasome degradation

Ubiquitin mediated proteolysis Antigen processing: Ubiquitination & Proteasome degradation

Glycosaminoglycan degradation Metabolic pathways Lysosome HS-GAG degradation MPS IIIC - Sanfilippo syndrome C Neutrophil degranulation +3 more

Base excision repair Autophagy - animal Necroptosis Neutrophil extracellular trap formation Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

AUF1 (hnRNP D0) binds and destabilizes mRNA mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Striated Muscle Contraction +3 more

Purine metabolism Pyrimidine metabolism Metabolic pathways Nucleotide metabolism Epstein-Barr virus infection Phosphate bond hydrolysis by NTPDase proteins Purinergic signaling in leishmaniasis infection +4 more

ABC-family proteins mediated transport Signaling by FGFR1 in disease Defective CFTR causes cystic fibrosis Signaling by plasma membrane FGFR1 fusions +1 more

Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism AMPK signaling pathway Insulin signaling pathway Alcoholic liver disease ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +8 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Endocytosis PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Pathways in cancer Prostate cancer Gastric cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling FGFR2c ligand binding and activation FGFR2b ligand binding and activation Signaling by FGFR2 amplification mutants Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling Negative regulation of FGFR2 signaling Signaling by FGFR2 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 fusions +26 more

Antifolate resistance Endocytosis Folate transport and metabolism COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport +3 more

Neutrophil extracellular trap formation Alcoholism Shigellosis Transcriptional misregulation in cancer Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex Condensation of Prophase Chromosomes DNA Damage/Telomere Stress Induced Senescence Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +12 more

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Systemic lupus erythematosus Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression Transcriptional regulation by small RNAs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Estrogen-dependent gene expression HCMV Early Events HCMV Late Events Amyloid fiber formation +33 more

Apelin signaling pathway Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis MicroRNAs in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX3 regulates p14-ARF +8 more