Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL CANCER	MONDO_0005575 MONDO:0005575	SAMD5	Unknown	35512400	GWAS catalog	—
		SASH1	Unknown	35512400	GWAS catalog	—
		SATB2	Unknown	31089142 38872215	GWAS catalog	SUMOylation of chromatin organization proteins
		SBF2	Unknown	31089142 38538606	GWAS catalog	RAB GEFs exchange GTP for GDP on RABs
		SBNO2	Unknown	33632709	GWAS catalog	—
		SCAF8	Unknown	26621817	GWAS catalog	—
		SCAI	Unknown	38538606	GWAS catalog	RHO GTPases Activate Formins
		SCG5	Unknown	18372905 21761138 23266556 26151821 30104761 30510241 30529582 31089142 31826910 32887889 36539618 37340002 38538606 38872215	GWAS catalog	—
		SCN3B	Unknown	38538606	GWAS catalog	Phase 0 - rapid depolarisation
		SCPEP1	Unknown	34290314	GWAS catalog	—
		SCUBE1	Unknown	36539618	GWAS catalog	Degradation of the extracellular matrix
		SDK2	Unknown	33627384	GWAS catalog	SDK interactions
		SDS	Unknown	38411962	GWAS catalog	Glycine, serine and threonine metabolism Cysteine and methionine metabolism Valine, leucine and isoleucine biosynthesis +4 more
		SEC11C	Unknown	35512400	GWAS catalog	Protein export Synthesis, secretion, and deacylation of Ghrelin
		SEPTIN4	Unknown	34290314	GWAS catalog	Apoptosis Apoptosis - multiple species Release of apoptotic factors from the mitochondria +1 more
		SEPTIN5	Unknown	38538606	GWAS catalog	Parkinson disease Pathways of neurodegeneration - multiple diseases
		SERPINH1	Unknown	26621817	GWAS catalog	Collagen biosynthesis and modifying enzymes
		SETD3	Unknown	33632709 36539618	GWAS catalog	PKMTs methylate histone lysines
		SETD6	Unknown	—	GenCC	PKMTs methylate histone lysines
		SF3A3	Unknown	30510241	GWAS catalog	Spliceosome mRNA Splicing - Major Pathway
		SFMBT1	Unknown	31089142 36539618 37340002	GWAS catalog	Polycomb repressive complex
		SFT2D1	Unknown	29698419	GWAS catalog	—
		SH2B3	Unknown	26151821 26621817 27197191 29917119 31826910	GWAS catalog	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SHANK2	Unknown	38411962	GWAS catalog	Glutamatergic synapse Neurexins and neuroligins
		SHISA3	Unknown	34794066	GWAS catalog	—
		SHISA9	Unknown	38538606	GWAS catalog	—
		SHROOM2	Unknown	31089142 34594039 36539618	GWAS catalog	—
		SKOR1	Unknown	31826910	GWAS catalog	—
		SLC15A1	Unknown	35512400	GWAS catalog	Protein digestion and absorption Proton/oligopeptide cotransporters
		SLC16A7	Unknown	35512400	GWAS catalog	Proton-coupled monocarboxylate transport
		SLC22A23	Unknown	25866641	GWAS catalog	—
		SLC22A3	Unknown	21242260 32887889	GWAS catalog	Choline metabolism in cancer Abacavir transmembrane transport Organic cation transport
		SLC22A31	Unknown	32887889	GWAS catalog	—
		SLC24A3	Unknown	29698419 35512400	GWAS catalog	Sodium/Calcium exchangers
		SLC25A17	Unknown	38538606	GWAS catalog	Peroxisome Alpha-oxidation of phytanate Class I peroxisomal membrane protein import
		SLC25A21	Unknown	29228715	GWAS catalog	Lysine catabolism
		SLC25A26	Unknown	30510241	GWAS catalog	Transport of inorganic cations/anions and amino acids/oligopeptides
		SLC25A28	Unknown	24737748 25990418 26151821 29917119 30510241 31089142 36539618 38872215	GWAS catalog	—
		SLC27A5	Unknown	36539618	GWAS catalog	Primary bile acid biosynthesis Metabolic pathways PPAR signaling pathway +5 more
		SLC28A3	Unknown	38538606	GWAS catalog	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
		SLC2A13	Unknown	38589358	GWAS catalog	Inositol transporters
		SLC35F3	Unknown	38411962	GWAS catalog	—
		SLC45A2	Unknown	33893285 34290314	GWAS catalog	Melanin biosynthesis
		SLC5A8	Unknown	38411962	GWAS catalog	Nicotinamide salvaging Organic anion transporters
		SLC6A18	Unknown	30510241 31089142 36539618 38872215	GWAS catalog	Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
		SLCO2A1	Unknown	29471430 30510241 30529582 31826910 34594039 36539618 37340002 38872215	GWAS catalog	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) Transport of organic anions
		SLITRK6	Unknown	34794066	GWAS catalog	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases
		SLK	Unknown	32887889 37340002	GWAS catalog	Oocyte meiosis
		SMAD3	Unknown	30510241 36539618 38872215	GWAS catalog	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD6	Unknown	30510241 31089142 34594039 36539618 37340002 38872215	GWAS catalog	TGF-beta signaling pathway Signaling by BMP RUNX2 regulates bone development
COLORECTAL CARCINOMA	EFO_1001951	SCG5	Unknown	37965154	GWAS catalog	—
COLORECTAL CARCINOMA	EFO_1001951	SLC2A13	Unknown	38589358	GWAS catalog	Inositol transporters
RECTUM CANCER	EFO_1000657	SCG5	Unknown	32887889	GWAS catalog	—
		SLC22A23	Unknown	25866641	GWAS catalog	—
		SLC24A3	Unknown	32887889	GWAS catalog	Sodium/Calcium exchangers

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Colorectal cancer

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