Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
COLORECTAL CANCER	MONDO_0005575 MONDO:0005575 114500	PFDN4	Unknown	26766742	GWAS catalog	—
		PHC3	Unknown	32887889	GWAS catalog	Polycomb repressive complex Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins +6 more
		PHF20	Unknown	34290314	GWAS catalog	HATs acetylate histones Regulation of TP53 Degradation Regulation of TP53 Activity through Association with Co-factors +1 more
		PIAS1	Unknown	25866641 31089142	GWAS catalog	Ubiquitin mediated proteolysis JAK-STAT signaling pathway Hepatitis C +8 more
		PIGU	Unknown	30510241 34290314 36539618	GWAS catalog	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis Metabolic pathways Attachment of GPI anchor to uPAR
		PIK3C2B	Unknown	32887889	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +2 more
		PIWIL4	Unknown	29228715	GWAS catalog	—
		PKM	Unknown	36539618 38408508	GWAS catalog	Glycolysis / Gluconeogenesis Pyruvate metabolism Metabolic pathways +9 more
		PLA2G2A	Unknown	—	ClinVar, GenCC	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +14 more
		PLA2G6	Unknown	32887889	GWAS catalog	Glycerophospholipid metabolism Ether lipid metabolism Arachidonic acid metabolism +12 more
		PLCB1	Unknown	30510241 31826910	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Rap1 signaling pathway +67 more
		PLCG2	Unknown	38538606	GWAS catalog	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +49 more
		PLCH1	Unknown	29471430	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Synthesis of IP3 and IP4 in the cytosol
		PLCL1	Unknown	30510241 31089142 36539618 38408508 38872215 40155373	GWAS catalog	GABAergic synapse
		PLEKHG6	Unknown	24836286 26965516 30510241 31089142 36539618 38872215 40155373	GWAS catalog	—
		PLEKHS1	Unknown	34758156	GWAS catalog	—
		PLXNA4	Unknown	38538606	GWAS catalog	Axon guidance Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion +1 more
		PNKD	Unknown	28960316 29917119 30510241 31089142 36539618 38408508 38872215	GWAS catalog	—
		PNMA8A	Unknown	24743840	GWAS catalog	—
		POLA2	Unknown	36869385	GWAS catalog	DNA replication Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere +6 more
		POLD3	Unknown	22634755 25990418 26151821 29917119 30510241 30529582 31089142 31826910 36539618 38408508 38872215	GWAS catalog	DNA replication Base excision repair Nucleotide excision repair +19 more
		POP4	Unknown	34290314	GWAS catalog	Ribosome biogenesis in eukaryotes tRNA processing in the nucleus
		POU2AF1	Unknown	38872215	GWAS catalog	—
		POU2AF2	Unknown	30510241 31089142 34594039 36539618 37340002 38538606 38872215 39392253	GWAS catalog	—
		POU2AF3	Unknown	18372901 21761138 23266556 24836286 25990418 26151821 26965516 28960316 29917119 30529582 31826910 37340002 38538606 38872215	GWAS catalog	—
		PPARGC1A	Unknown	38538606	GWAS catalog	AMPK signaling pathway Longevity regulating pathway Apelin signaling pathway +12 more
		PPHLN1	Unknown	38538606	GWAS catalog	—
		PPP1R21	Unknown	30529582	GWAS catalog	—
		PPP1R3A	Unknown	35512400	GWAS catalog	Insulin signaling pathway Insulin resistance
		PPP1R42	Unknown	38538606	GWAS catalog	—
		PRDM1	Unknown	36539618	GWAS catalog	Regulation of TP53 Expression
		PREP	Unknown	31089142 36539618	GWAS catalog	Renin-angiotensin system
		PRICKLE2	Unknown	36539618	GWAS catalog	Wnt signaling pathway
		PRKCA	Unknown	37890997	GWAS catalog	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +87 more
		PRKCI	Unknown	32887889	GWAS catalog	Rap1 signaling pathway Endocytosis Hippo signaling pathway +7 more
		PRKN	Unknown	29228715	GWAS catalog	Ubiquitin mediated proteolysis Mitophagy - animal Protein processing in endoplasmic reticulum +8 more
		PRMT6	Unknown	37340002	GWAS catalog	RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		PRPF38A	Unknown	35512400	GWAS catalog	Spliceosome mRNA Splicing - Major Pathway
		PRR18	Unknown	29698419 34794066	GWAS catalog	—
		PSCA	Unknown	34290314 37340002	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		PSMG4	Unknown	25866641	GWAS catalog	—
		PTBP3	Unknown	29228715	GWAS catalog	—
		PTCHD3	Unknown	36077729	GWAS catalog	—
		PTCHD4	Unknown	38411962	GWAS catalog	—
		PTHLH	Unknown	32887889	GWAS catalog	Hormone signaling Parathyroid hormone synthesis, secretion and action Class B/2 (Secretin family receptors) +2 more
		PTPN1	Unknown	38872215	GWAS catalog	Adherens junction Insulin signaling pathway Insulin resistance +7 more
		PTPN12	Unknown	—	ClinVar, HPO	SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF +3 more
		PTPN2	Unknown	31826910	GWAS catalog	JAK-STAT signaling pathway Negative regulation of MET activity Regulation of IFNG signaling +1 more
		PTPRA	Unknown	40155373	GWAS catalog	NCAM signaling for neurite out-growth RAF/MAP kinase cascade
		PTPRD	Unknown	29228715	GWAS catalog	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
COLORECTAL CARCINOMA	EFO_1001951	POU2AF2	Unknown	37965154	GWAS catalog	—
RECTUM CANCER	EFO_1000657	PIAS1	Unknown	25866641	GWAS catalog	Ubiquitin mediated proteolysis JAK-STAT signaling pathway Hepatitis C +8 more
		PLCL1	Unknown	32887889	GWAS catalog	GABAergic synapse
		POU2AF2	Unknown	32887889	GWAS catalog	—
		PSMG4	Unknown	25866641	GWAS catalog	—

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Colorectal cancer

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