Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
colon adenocarcinoma	MONDO_0002271	MAML2	Unknown	22810696 29937994 26336987 25957691 25344691 29844865 31336886 24755471 38725616	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP2K1	Unknown	29967250 34680263 19411838 22402123 29937994 31227518 26416732 25957691 25344691 29844865 24755471 22895193 22327936 28481359 21726664 31226844	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K2	Unknown	34680263 26071483 22402123 22895193 25957691 30239619 29844865 24755471 18186519 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +87 more
		MAP2K4	Unknown	22810696 26071483 26416732 30631260 23856246 25957691 27245685 30239619 25344691 9331070 38725616 24755471 22895193 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	22810696 30038269 29937994 26416732 29316426 28145097 25957691 23856246 26336987 30239619 32375028 25344691 24755471 22895193 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	22810696 29937994 29316426 25957691 30239619 25344691 31336886 24755471 22895193 28481359	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	22810696 29937994 25344691 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MAX	Unknown	22810696 26071483 26764183 29937994 26416732 29316426 23856246 25957691 30239619 25344691 38725616 22895193 28481359	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MB21D2	Unknown	22810696 29937994 26416732 25344691 38725616 24755471 22895193	Open Targets	—
		MDM2	Unknown	22810696 29967250 25957691 25344691 29844865 31336886 24755471 22895193 28481359	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MDM4	Unknown	22810696 29967250 26071483 29316426 25957691 25344691 28481359	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MECOM	Unknown	22810696 26071483 26764183 29937994 26336987 25957691 26109429 25344691 38725616 24755471 22895193	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	22810696 27023146 29937994 23132392 26416732 23856246 25957691 28145097 29316426 25344691 22895193 28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	22810696 29937994 29316426 25957691 30239619 25344691 29844865 24755471 28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	22810696 18186519 27023146 26071483 29665843 25617745 34680263 29937994 26416732 27756406 26109429 30239619 25344691 26968814 29844865 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MGMT	Unknown	26416732 22895193 25957691 30239619 25344691 26764183	Open Targets	MGMT-mediated DNA damage reversal
		MITF	Unknown	22810696 26071483 29937994 29316426 23856246 25957691 30239619 25344691 29844865 24755471 22895193 28481359	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLF1	Unknown	26416732 25957691 30239619 38725616 24755471 22895193	Open Targets	Transcriptional misregulation in cancer
		MLH1	Unknown	22810696 28481359 27612425 22895193 29316426 27756406 25957691 26336987 25194673 28978093 32664968 12386821 25344691 23471846 38725616 24755471 20473912 10793088 20176655	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	22810696 24755471 26416732 22895193 25344691	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MLLT10	Unknown	22810696 29967250 26071483 29937994 26416732 25957691 30239619 25344691 29844865 24755471 22895193	Open Targets	—
		MLLT11	Unknown	22895193 25957691 29937994	Open Targets	—
		MLLT3	Unknown	26071483 29937994 26416732 26336987 25957691 25344691 38725616 22895193	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MN1	Unknown	26071483 26416732 28546418 25957691 26109429 32375028 25344691 29844865 24755471 22895193 17932254	Open Targets	—
		MNX1	Unknown	22810696 26416732 23856246 25957691 25344691 31336886 22895193	Open Targets	Maturity onset diabetes of the young
		MPL	Unknown	22810696 26416732 27756406 25344691 29844865 22895193 28481359	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MRTFA	Unknown	22810696 26071483 29937994 26416732 26336987 25957691 32375028 25344691 38725616 24755471	Open Targets	SUMOylation of transcription cofactors RHO GTPases Activate Formins
		MSI2	Unknown	22810696 26416732 22895193 25957691 29937994	Open Targets	mRNA surveillance pathway
		MSN	Unknown	22810696 29937994 26416732 25344691 38725616 22895193	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MTCP1	Unknown	25957691 26336987 22895193 25344691 22810696	Open Targets	PI3K-Akt signaling pathway
		MTOR	Unknown	22810696 29967250 34680263 29665843 26764183 29937994 21203531 26416732 29316426 23856246 25957691 25344691 29844865 38725616 24755471 22895193 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC1	Unknown	26071483 23856246 16959974 29844865 25344691 22895193	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +4 more
		MUC16	Unknown	22810696 30038269 26071483 27302369 26764183 27612425 29937994 26416732 26336987 28546418 25957691 26109429 30239619 32375028 25344691 31336886 24755471 22895193 17932254	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	22810696 26071483 27302369 27612425 26416732 26336987 25957691 26109429 30239619 32375028 25344691 24755471 22895193	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	22810696 26764183 29937994 26416732 25957691 30239619 25344691 31336886 24755471 22895193	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	22810696 29316426 25957691 25344691 29844865 24755471 22895193 28481359	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYB	Unknown	29937994 26416732 25957691 26109429 25344691 29844865 24755471	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYC	Unknown	34680263 26071483 26416732 29316426 25957691 25344691 29844865 28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYCL	Unknown	22810696 21203531 23856246 25344691 26764183 28481359	Open Targets	—
		MYCN	Unknown	26764183 29937994 29316426 25957691 30239619 32375028 25344691 29844865 24755471 22895193 28481359	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	26416732 26071483 25344691 28481359	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	22810696 29967250 26071483 26764183 29937994 26416732 26336987 23856246 25957691 28546418 25344691 29844865 38725616 24755471 22895193	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYH9	Unknown	22810696 26071483 26764183 29937994 25957691 26109429 25344691 29844865 24755471 22895193	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	22810696 29937994 26416732 26336987 25957691 30239619 25344691 38725616 24755471 22895193	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		MYOD1	Unknown	24943349 26071483 29316426 25957691 25344691 22895193 28481359	Open Targets	Spinocerebellar ataxia Myogenesis
		N4BP2	Unknown	22810696 26071483 29937994 26416732 26336987 23856246 25957691 25344691 24755471 22895193	Open Targets	—
		NAB2	Unknown	29937994 26416732 25957691 25344691 24755471 22895193	Open Targets	NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
		NACA	Unknown	22810696 29937994 26416732 25957691 30239619 25344691 24755471 22895193	Open Targets	Parathyroid hormone synthesis, secretion and action
		NBEA	Unknown	22810696 26071483 27612425 29937994 26416732 26336987 25957691 26109429 30239619 32375028 25344691 38725616 24755471 22895193 17932254	Open Targets	—
		NBN	Unknown	26071483 29937994 29316426 25957691 26109429 32375028 25344691 29844865 24755471 22895193 28481359	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more

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Colon adenocarcinoma

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